Protein Alignment 18w and Tollo

DIOPT Version :10

• Sequence 1: NP_476814.1
• Gene: 18w / 37277
• FlyBaseID: FBgn0287775
• Length: 1385
• Species: Drosophila melanogaster
• Sequence 2: XP_551799.3
• Gene: Tollo / 3291574
• VectorBaseID: AGAMI1_004851
• Length: 1352
• Species: Anopheles gambiae
• Alignment Length: 1385
• Identity: 522/1385 - (37%)
• Similarity: 780/1385 - (56%)
• Gaps: 101/1385 - (7%)

  Fly     2 PATSSII--TIIAVAACLLLLVADAHAQQQCNWQYGLTTMDIR--CSVRALESG-TGTPLDLQVA 61
            ||..:::  ||..|....|.....:.|..:|.|. |.|..|:.  |.:|.:.|. ..|...:...
Mosquito     5 PALLTVLFGTIFGVFGASLSKSLVSQAPDECRWD-GYTEDDLTLLCRLRTINSELENTNFSVLHP 68

  Fly    62 EAAGRLDLQCSQELLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNA 126
            |...||.|||:..|...|.|:||.|:||.||..|.|:.||:..:...:|:||..|..|||.:||.
Mosquito    69 ENTVRLRLQCNDGLFFQSSLSPGSFKQLTKLHALSIEYCKIANLSEGSFQGLKQLVNLTLRTHNT 133

  Fly   127 VWGPGKTLELHGQSFQG-LKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFS 190
            .|. ..:|::..|.|.. |.:|..|.|..||:..:|:|..|.:..|..:||||||:|......||
Mosquito   134 DWS-SISLDIAPQVFTSELAKLQRLDLSQNNMWSVPDGFICPLARLSYINLTQNRLRDLSVFHFS 197

  Fly   191 EKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNAL 255
            ..|  .:.||.     ..||.:.|||:|.|.:.:||.|. .|.|.:|..|.||.|.::.:|..|.
Mosquito   198 ASL--STRLSK-----KCGSSIVTLDLSHNTIDNLPPAI-FSGLGKLTDLRLQSNGLNYIADRAF 254

  Fly   256 AGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLT 320
            .||.||..|.:|.|.|.:||.|.|:..|.::|::||.|.|..|..|:...|:||||||||.|:||
Mosquito   255 EGLVSLSRLELSLNRLTNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELT 319

  Fly   321 SHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHT 385
            |..::.:||.||.:||:|:||||.:|::....|::|..:|:|.::.|.|..|.|..||.|..|||
Mosquito   320 SEWINPATFRGLSKLILLDLSNNKITKLEPTIFRDLTSVQVLRLQENFIESIGENTFLGLGALHT 384

  Fly   386 LNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQD 450
            :.|:.|||.|:|:..|:||..|..|:|:.|.:|.::.||.||.|.|:||.|:.|:|.:||:|:.|
Mosquito   385 VILSNNRLCTVDHFTFSGLNSLALLSLDYNRISRIDRQALRNHSALQELHLNGNKLLQVPDALYD 449

  Fly   451 LSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSI 515
            :.:|:|||||||.||...|.:||::..|.||||.:|.|..|..|.|:.:..|.:|||::||::::
Mosquito   450 VPLLRTLDLGENHISNIDNASFRHMAHLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNRLKTV 514

  Fly   516 ERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNY 580
            |:.:||.||:::|||||.|:||||.|:|..|.:|||||:|:|||..||||.||:.|:|||||.|.
Mosquito   515 EQASFDNNTKLQAIRLDGNYLTDIAGLFTKLPNLLWLNISDNHLEVFDYALIPTGLQWLDIHANK 579

  Fly   581 IEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARV 645
            |..||||::::.::.::|:|||.|::|||...::|||:|||::|:|:|.::|:.||..|..|.||
Mosquito   580 ITELGNYFEIESQLALSTIDASSNQLTEITGSAIPNSVELLYLNDNLISKVQSYTFFKKPNLTRV 644

  Fly   646 DLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNI 710
            ||:.|.::.:..||||::.|..::|:||||:||||::|||::.|||: :|:.:|..|.::||.:|
Mosquito   645 DLFGNKITTLDPNALRISAVPDDRPLPEFYIGGNPYQCDCNLNWLQK-SNIDSRTQPRLMDLDSI 708

  Fly   711 ECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNI 775
            .|.:.::|.....||.....:.|:|||::||...||||::..|:|::.||..|:|:||.:|::|:
Mosquito   709 YCKLLYNRGRTYVPLVEALPNQFLCKYDTHCFALCHCCDFYACDCKMECPKQCTCYHDQSWSSNV 773

  Fly   776 VDCGRQDL-AALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQL 839
            |||.|... ..||::||.|.:.:||||||...|......||:.|:.|:||.||:.|:.|.:...|
Mosquito   774 VDCSRAGYDDRLPDQIPMDSTQIYLDGNNFRSLSSHAFLGRKRLKILFLNGSNVETVSNRTFYGL 838

  Fly   840 VNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLP 904
            ..|.:|.|::|.||||.|.||..|..|:||:|..|.:..|:|.||:.|..|::||||:|||....
Mosquito   839 KELEILQLDHNLLTALNGFEFEGLDSLKELFLQYNRIASIANHTFDHLHGLKILRLDHNRLVEFN 903

  Fly   905 HLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYC----------------LD 953
            .......|..:.|..|||||.|..:....:::..... |||.|.|.|                .|
Mosquito   904 VWLLPKQLNDIRLAFNAWSCECDYVTRFQEYLKTYDF-VRDRHKIRCASYVSSNATIAPATQPAD 967

  Fly   954 AGIKRELELIGNLANGPDCSDLL---DASAS--------------NISSSQDLAG-----GYRLP 996
            |......|  ..|.:|....|.|   |.|::              |::|.:.:..     || :|
Mosquito   968 ASQASPAE--EPLPDGAGTGDFLVYYDNSSTLCTGAIPLENVINGNLTSRKTILSPQPIEGY-IP 1029

  Fly   997 LLAAVLVLIFLVVVL-IIVFVFRESVRMWLFAHYGVRV----CEPRFEDAGKLYDAIILHSEKDY 1056
            ||...|....||::| :::||||:.:|:|..:.:|||:    .:....:..||:||.|.:|.||.
Mosquito  1030 LLVTGLFGFSLVIILTLVLFVFRQEMRVWFHSKFGVRLFYRNADIDKNERDKLFDAFISYSSKDE 1094

  Fly  1057 EFVCRNIAAELEHGRPPFRLCIQQRDLPPQA----SHLQLVEGARASRKIILVLTRNLLATEWNR 1117
            .||...:|..||:..|.::||:..||.|..|    :.||.||   :||:.|:||:.|.:.:||.|
Mosquito  1095 AFVAEELAPMLENEDPSYKLCLHYRDFPVGAYIADNILQAVE---SSRRTIMVLSENFIKSEWCR 1156

  Fly  1118 IEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYLKSVPSNRLLTCDRYFWEKLRYAIPI 1182
            .||::|.|:.||...::|::|....|..:..| .::..|||:  :..|...|:.||||||:|:|
Mosquito  1157 FEFKSAHHQVLRDRRRRLIVILLGEVPQKDLD-PDIRLYLKT--NTYLQWGDKLFWEKLRFALP- 1217

  Fly  1183 ELSPRGNNYTLDHHERFKQPVSPGMIFRQAPPPPAYYCTEEMEANYSSATTATPSPRPTRPGGAA 1247
               ...||....|        .|.:....:....:|..|....:|.::.........|..|.|.:
Mosquito  1218 ---DVPNNQRRQH--------QPNISLTHSNVRNSYQLTRVAPSNRTNNQLTAQHQDPRGPQGRS 1271

  Fly  1248 RIVDSMPMPMRPPSEHIYHSIESEYSAYDQHEALSMIPTGLMHQHQQQQLRLHQQQQQQQQQRLL 1312
            ....:...|:..|      .:.||......|.:        ..|.||||.:..|||||||||:..
Mosquito  1272 TDYHATQQPLPLP------GLASEMQPQQLHSS--------QQQQQQQQQQQQQQQQQQQQQQQQ 1322

  Fly  1313 QPQFRAMPQQAIPAPSAPVH 1332
            |.|.:....||...||||::
Mosquito  1323 QQQHQPPSTQAQLRPSAPLN 1342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380	13/24 (54%)
		leucine-rich repeat	92..115	CDD:275380	8/22 (36%)
		LRR_8	115..181	CDD:404697	25/66 (38%)
		leucine-rich repeat	116..146	CDD:275380	11/30 (37%)
		leucine-rich repeat	147..170	CDD:275380	8/22 (36%)
		leucine-rich repeat	171..201	CDD:275380	12/29 (41%)
		LRR	210..592	CDD:443914	180/381 (47%)
		leucine-rich repeat	212..236	CDD:275380	10/23 (43%)
		leucine-rich repeat	237..260	CDD:275380	9/22 (41%)
		leucine-rich repeat	261..284	CDD:275380	9/22 (41%)
		leucine-rich repeat	285..308	CDD:275380	8/22 (36%)
		leucine-rich repeat	309..334	CDD:275380	15/24 (63%)
		leucine-rich repeat	335..358	CDD:275380	10/22 (45%)
		leucine-rich repeat	359..382	CDD:275380	9/22 (41%)
		leucine-rich repeat	383..406	CDD:275380	12/22 (55%)
		leucine-rich repeat	407..430	CDD:275380	9/22 (41%)
		leucine-rich repeat	431..451	CDD:275380	9/19 (47%)
		leucine-rich repeat	454..477	CDD:275380	13/22 (59%)
		leucine-rich repeat	478..499	CDD:275380	10/20 (50%)
		leucine-rich repeat	502..525	CDD:275380	10/22 (45%)
		leucine-rich repeat	526..548	CDD:275380	13/21 (62%)
		leucine-rich repeat	590..617	CDD:275380	9/26 (35%)
		leucine-rich repeat	618..641	CDD:275380	10/22 (45%)
		leucine-rich repeat	642..689	CDD:275380	23/46 (50%)
		LRRCT	679..736	CDD:214507	19/56 (34%)
		LRR	<775..>920	CDD:443914	59/145 (41%)
		leucine-rich repeat	775..796	CDD:275380	9/21 (43%)
		leucine-rich repeat	797..817	CDD:275380	9/19 (47%)
		leucine-rich repeat	818..841	CDD:275380	9/22 (41%)
		leucine-rich repeat	842..865	CDD:275380	12/22 (55%)
		leucine-rich repeat	866..889	CDD:275380	10/22 (45%)
		leucine-rich repeat	890..911	CDD:275380	8/20 (40%)
		TIR	1045..1183	CDD:214587	54/141 (38%)
Tollo	XP_551799.3	None