DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Lrig3

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_796126.4 Gene:Lrig3 / 320398 MGIID:2443955 Length:1117 Species:Mus musculus


Alignment Length:1152 Identity:248/1152 - (21%)
Similarity:425/1152 - (36%) Gaps:283/1152 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 AVAACLLLLVA--------------------DAHAQQQCNWQYGLTTMDIRCSVRALESGTGTPL 56
            |.||..|||.|                    |..||:.|..........:.||.|.|.. ...||
Mouse     9 ATAALGLLLCAGLGRAGPAGSGGHGAPGQLLDDDAQRPCPAACHCLGDLLDCSRRRLVR-LPDPL 72

  Fly    57 DLQVAEAAGRLDLQCSQ-ELLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLT 120
            ...|.    ||||..:: ..:..|.|:     .||.|.|::::..:|:.: ||......::::|:
Mouse    73 PAWVT----RLDLSHNRLSFIQTSSLS-----HLQSLQEVKLNNNELETI-PNLGSISANIRQLS 127

  Fly   121 LESHNAVWGPGKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQL--LNLTQNRIRS 183
            | :.||:   .|.|....::||.|:.|.   |.:|||.:|.    .:.|.|||  |.:..||:.|
Mouse   128 L-AGNAI---DKILPEQLEAFQSLETLD---LSNNNISELR----TAFPPLQLKYLYINNNRVSS 181

  Fly   184 AEFLGFSEKLCAGSALSNAN-GAVSG-------GSELQTLDVSFNELRSLPDAWGASRLRRLQTL 240
            .| .|:.:.|.:...:...| ..:|.       ..:||.|:::.|::::: |......|..|::|
Mouse   182 ME-PGYFDNLASTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNV-DGLTFQGLGALKSL 244

  Fly   241 SLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHR 305
            .:|.|.::.|...|..|||::.||.:.:|:|..:......|...||||||..|.:..:.......
Mouse   245 KMQRNGVTKLMDGAFWGLSNMEVLQLDHNNLTEITKGWLYGLLMLRELHLSQNAINRISPDAWEF 309

  Fly   306 LEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIG 370
            .::|..|||:.|.|:  .:|:|:|.||..|..|::.||.::.|....|:.|..|:.||:|||.|.
Mouse   310 CQKLSELDLTFNHLS--RLDDSSFLGLSLLNALHIGNNKVSYIADCAFRGLTSLKTLDLRNNEIS 372

  Fly   371 -HIEE--GAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLK 432
             .||:  |||..|..|..|.|..||:.::..:.|.||..|..|.|:.|.:..::|.||.....|:
Mouse   373 WTIEDMSGAFSGLDRLRQLILQGNRIRSITKKAFAGLDTLEHLDLSGNAIMSLQSNAFSQMKKLQ 437

  Fly   433 ELDLSSN------QLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNI 491
            :|.|:::      ||..:|:.|           .||....|.|.:..:...|.|..:       .
Mouse   438 QLHLNTSSLLCDCQLRWLPQWV-----------AENNFQSFVNASCAHPQLLKGRSI-------F 484

  Fly   492 TVG----MFQDLPRLSVLNLAKNRIQSIERG---------AFDKNTEIE-AIRLDKNFLTDINGI 542
            ||.    :..|.|:..:  ..:...||..:|         |...::.:. |.:.|...|.|    
Mouse   485 TVSPDGFVCDDFPKPQI--TVQPETQSAIKGSDVSFTCSAASSSDSPMTFAWKKDNEALQD---- 543

  Fly   543 FATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNY----YKLQEEIRVTTLDASH 603
             |.:.:...|......|:.:.......|:::.. .|.|...:.|:    |.::.::.:..|.:..
Mouse   544 -AEMENYAHLRAQGGELMEYTTILRLRNVEFTS-EGKYQCVISNHFGSSYSVKAKLTINMLPSFT 606

  Fly   604 NRITEI----GAMSVPNSIELLFINN---NIIGQIQANT-------------------FVDKTRL 642
            ....::    |||:   .:|...:.:   .|..|....|                   |:...::
Mouse   607 KTPMDLTIRAGAMA---RLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKI 668

  Fly   643 ARVDLYA----NVLSKISLNA--------------LRVAPVSAEKPVPEFYLGGNPFECDCSMEW 689
            ..:.:|:    |....:|.||              |.......|..|.:...||:|   ...:.|
Mouse   669 EDIGVYSCTAQNSAGSVSANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSP---PPRLNW 730

  Fly   690 LQRINNL-TTRQH-------------PHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESH 740
            .:..:.| .|.:|             ..|.|.|...|.|.::.... |....||...        
Mouse   731 TKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTE-RGNVRLSVIP-------- 786

  Fly   741 CPPTCHCCEYEQCECE-------------VICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQ 792
             .|||..........:             |:|   |.......|...|....|::         :
Mouse   787 -TPTCDSPHMTAPSLDGDGWATVGVVIIAVVC---CVVGTSLVWVVIIYHTRRRN---------E 838

  Fly   793 DVSDLYLDGNNMPELEVGHLTGRRNL---RALYLNASN-----LMTLQNGS--LAQLVNLRVLHL 847
            |.|....|..|:|.....:|:.:..|   :..|:::.:     .:|...|.  |.|.......|.
Mouse   839 DCSITNTDETNLPADIPSYLSSQGTLADRQDGYISSESGSHHQFVTSSGGGFFLPQHDGAGTCHF 903

  Fly   848 ENNKLTALEGTEFRSL----GLLRELYLHNNMLT------HISNATFEPLVSL----EVLRLDNN 898
            :::....:|......|    |....:||..|:.:      ::...:.:|..:|    |...:..:
Mouse   904 DDSSEADVEAASDPFLCPFVGSTGPVYLQGNLYSPDPFEVYLPGCSSDPRTALMDHCESSYVKQD 968

  Fly   899 RLS-----------SLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDI--Y 950
            |.|           ||..:.:.||                  |:|    :|:.....:.|.:  .
Mouse   969 RFSCARPSEEPCERSLKSIPWPHS------------------RKL----TDSTYPPNEGHTVQTL 1011

  Fly   951 CLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPL 997
            ||:   |..::    .:.||:        ..:.:||....|.:..||
Mouse  1012 CLN---KSSVD----FSTGPE--------PGSATSSNSFMGTFGKPL 1043

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 7/25 (28%)
leucine-rich repeat 92..115 CDD:275380 5/22 (23%)
LRR_8 115..181 CDD:404697 21/67 (31%)
leucine-rich repeat 116..146 CDD:275380 9/29 (31%)
leucine-rich repeat 147..170 CDD:275380 6/22 (27%)
leucine-rich repeat 171..201 CDD:275380 10/31 (32%)
LRR 210..592 CDD:443914 106/408 (26%)
leucine-rich repeat 212..236 CDD:275380 6/23 (26%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 5/22 (23%)
leucine-rich repeat 285..308 CDD:275380 7/22 (32%)
leucine-rich repeat 309..334 CDD:275380 11/24 (46%)
leucine-rich repeat 335..358 CDD:275380 7/22 (32%)
leucine-rich repeat 359..382 CDD:275380 13/25 (52%)
leucine-rich repeat 383..406 CDD:275380 8/22 (36%)
leucine-rich repeat 407..430 CDD:275380 7/22 (32%)
leucine-rich repeat 431..451 CDD:275380 7/25 (28%)
leucine-rich repeat 454..477 CDD:275380 4/22 (18%)
leucine-rich repeat 478..499 CDD:275380 4/24 (17%)
leucine-rich repeat 502..525 CDD:275380 4/31 (13%)
leucine-rich repeat 526..548 CDD:275380 5/22 (23%)
leucine-rich repeat 590..617 CDD:275380 4/30 (13%)
leucine-rich repeat 618..641 CDD:275380 5/44 (11%)
leucine-rich repeat 642..689 CDD:275380 11/64 (17%)
LRRCT 679..736 CDD:214507 13/70 (19%)
LRR <775..>920 CDD:443914 30/179 (17%)
leucine-rich repeat 775..796 CDD:275380 3/20 (15%)
leucine-rich repeat 797..817 CDD:275380 4/19 (21%)
leucine-rich repeat 818..841 CDD:275380 6/32 (19%)
leucine-rich repeat 842..865 CDD:275380 3/26 (12%)
leucine-rich repeat 866..889 CDD:275380 4/28 (14%)
leucine-rich repeat 890..911 CDD:275380 6/35 (17%)
TIR 1045..1183 CDD:214587
Lrig3NP_796126.4 LRRNT 46..74 CDD:214470 7/28 (25%)
LRR 1 75..98 7/31 (23%)
leucine-rich repeat 76..99 CDD:275378 8/31 (26%)
LRR 77..421 CDD:443914 110/368 (30%)
LRR 2 99..120 5/21 (24%)
leucine-rich repeat 100..146 CDD:275378 12/50 (24%)
LRR 3 122..143 6/24 (25%)
LRR 4 146..168 8/28 (29%)
leucine-rich repeat 147..168 CDD:275380 8/27 (30%)
leucine-rich repeat 169..192 CDD:275380 8/23 (35%)
LRR 5 169..189 7/20 (35%)
LRR 6 193..214 2/20 (10%)
leucine-rich repeat 194..216 CDD:275380 2/21 (10%)
LRR 7 216..237 5/21 (24%)
leucine-rich repeat 217..240 CDD:275380 6/23 (26%)
LRR 8 240..261 6/20 (30%)
leucine-rich repeat 241..264 CDD:275380 8/22 (36%)
LRR 9 264..285 4/20 (20%)
leucine-rich repeat 265..288 CDD:275380 5/22 (23%)
LRR 10 288..309 7/20 (35%)
leucine-rich repeat 289..312 CDD:275380 7/22 (32%)
LRR 11 312..333 9/22 (41%)
leucine-rich repeat 313..336 CDD:275380 11/24 (46%)
LRR 12 336..357 6/20 (30%)
leucine-rich repeat 337..360 CDD:275380 7/22 (32%)
LRR 13 360..382 10/21 (48%)
leucine-rich repeat 361..385 CDD:275380 12/23 (52%)
LRR 14 387..408 6/20 (30%)
leucine-rich repeat 388..411 CDD:275380 8/22 (36%)
LRR 15 411..432 7/20 (35%)
leucine-rich repeat 412..433 CDD:275380 7/20 (35%)
PCC 416..>494 CDD:188093 20/95 (21%)
Ig_3 498..585 CDD:464046 14/94 (15%)
IgI_LRIG1-like 604..694 CDD:409420 13/92 (14%)
Ig strand A 604..607 CDD:409420 0/2 (0%)
Ig strand A' 611..615 CDD:409420 0/3 (0%)
Ig strand B 618..627 CDD:409420 3/11 (27%)
Ig strand C 633..638 CDD:409420 1/4 (25%)
Ig strand C' 641..643 CDD:409420 0/1 (0%)
Ig strand D 651..655 CDD:409420 0/3 (0%)
Ig strand E 659..666 CDD:409420 1/6 (17%)
Ig strand F 672..680 CDD:409420 1/7 (14%)
Ig strand G 683..694 CDD:409420 3/10 (30%)
I-set 697..784 CDD:400151 17/90 (19%)
Ig strand B 714..718 CDD:409544 1/3 (33%)
Ig strand C 727..731 CDD:409544 0/3 (0%)
Ig strand E 750..754 CDD:409544 0/3 (0%)
Ig strand F 764..769 CDD:409544 1/4 (25%)
Ig strand G 777..780 CDD:409544 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1019..1093 7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

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