DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and Tlr7

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	XP_017457568.1	Gene:	Tlr7 / 317468	RGDID:	1563357	Length:	1068	Species:	Rattus norvegicus

Alignment Length:	1245	Identity:	292/1245 - (23%)
Similarity:	490/1245 - (39%)	Gaps:	325/1245 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PLDLQVAEAAGRLDLQCSQELLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRL 119
            |.|:.:......:.:.|:.:  |.:|:..|:......|: |.|:  .:..:.|::|..|..|:.|
  Rat    53 PCDVSLDSTNTHVIVDCTDK--HLTEIPEGIPTNTTNLT-LTIN--HIPSISPDSFHRLKHLEEL 112

  Fly   120 TLESHNAVWGP----------GKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMP-SLQL 173
            .|.. |.|  |          .|.|::...||.||.:|..|:|..|.:.::|:    .:| ||||
  Rat   113 DLRC-NCV--PILLGSKANVCTKRLQIRPGSFSGLSDLKSLYLDGNQLLEIPQ----DLPSSLQL 170

  Fly   174 LNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQ 238
            |:|..|.|.|               ::..|                           .|.|..::
  Rat   171 LSLEANNIFS---------------ITKEN---------------------------LSELVNIE 193

  Fly   239 TLSLQHN-------NIS-TLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDL 295
            :|.|..|       |:| ::..:|...:.:|:||::..|::.::|:..   ...|.||:|..|.:
  Rat   194 SLYLGQNCYYRNPCNVSYSIEKDAFLVMKNLKVLSLKDNNVTAVPTIL---PPNLLELYLYNNII 255

  Fly   296 YELPKGLLHRLEQLLVLDLSGNQLTSHHV----------------DNSTFAGLIRLIVLNLSNNA 344
            ..:.:...::|.||.|||||||....::|                ||: |..|..|.||.|.:|:
  Rat   256 KRIQEHDFNKLSQLQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNA-FDSLTELKVLRLHSNS 319

  Fly   345 LTRIGSKTFKELYFLQILDMRNNSIG-HIEEGAFL-PLYNLHTLNLAEN---RLHTLDNRIFNGL 404
            |..:.::.||.:..||.||:..|.:. .|||..|| .|.||..|:|:.|   :::.....:.:.|
  Rat   320 LQHVPAEWFKNMSNLQELDLSQNYLAREIEEAKFLNSLPNLVQLDLSFNYELQVYHASITLPHSL 384

  Fly   405 YVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKN 469
            ..||||   .||  .::...|:   :||:..||         .:.:||.|:.||||.|.|.....
  Rat   385 SSLTKL---KNL--YIKGYVFK---ELKDSSLS---------VLHNLSNLEVLDLGTNFIKIADL 432

  Fly   470 NTFRNLNQLTGLRLIDNRIGNIT-------VGMFQDL--------PR-LSVLNLAKNRIQSIERG 518
            |.|:   |...|:.||..:..|:       ||:..:.        |: |..|:..  |.....|.
  Rat   433 NIFQ---QFENLKFIDLSVNKISPSEESREVGLCPNAQTSVDWHGPQVLEALHYF--RYDEYARS 492

  Fly   519 AFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWF---DYAFIPSNLKWLDIHGNY 580
            ...||.|      ...|| .:|....|....  |:||.|::.:.   |:..: |.||.|::.||.
  Rat   493 CRFKNKE------PPTFL-PLNADCHTYGKT--LDLSRNNIFFIKPSDFKHL-SFLKCLNLSGNA 547

  Fly   581 IEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARV 645
            |....|..:||....:..||.|:||            ::||:          :..|.:...|..:
  Rat   548 IGQTLNGSELQPLRELRYLDFSNNR------------LDLLY----------STAFEELQNLEIL 590

  Fly   646 DLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNI 710
            ||.:|                           .:.|:.    |.:..:.|.|.:       |.::
  Rat   591 DLSSN---------------------------SHYFQA----EGITHMLNFTKK-------LRHL 617

  Fly   711 ECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFH-DATWATN 774
            |.||.:...      .|.|||..:   ||.   :....|:.         ||    | |..|.
  Rat   618 EKLMMNDND------ISTSASRTM---ESE---SLRVLEFR---------GN----HLDVLWR-- 655

  Fly   775 IVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGR-RNLRALYLNASNLMTLQNGSLAQ 838
              |...:.|....|.:  ::.:|.:..|::..:..|...|. .||..|.|..:.|.:...|.|..
  Rat   656 --DGDNRYLDFFKNLL--NLEELDISRNSLNSVPPGVFEGMPPNLTTLSLAKNGLRSFSWGRLQL 716

  Fly   839 LVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRL--- 900
            |.:|:.|.|.:|:||.:..........|.:|.|::|.:..::....|..:.|..|.:.:|::
  Rat   717 LKHLKNLDLSHNQLTTVPARLANCSKSLTKLILNHNQIRQLTKYFLEDALQLRYLDISSNKIQVI 781

  Fly   901 --SSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELI 963
              :|.|. ...::|..|.|..|.:.|.|..:..:......:..:...|.|:.|...|..:...:|
  Rat   782 QKTSFPE-NVLNNLNMLLLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCAGPGAHKGQSVI 845

  Fly   964 G------NLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVR 1022
            .      .|    |.::|:..|.| |||                  ::||::|:....:|...
  Rat   846 SLDLYTCEL----DLTNLILFSVS-ISS------------------VLFLMIVMTTSHLFFWD-- 885

  Fly  1023 MWLFAHY------GVRVCEPRFEDAGKLYDAIILHSEKD---YEFVCRNIAAELEHGRPP-FRLC 1077
            ||...::      |.:    ..:.....|||.|::..|:   .|:|.:.:..:||..|.. |.||
  Rat   886 MWYIYYFWKAKIKGYQ----HLQSMESCYDAFIVYDTKNSAVTEWVLQELVVKLEDPREKHFNLC 946

  Fly  1078 IQQRD-LPPQASHLQLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEET 1141
            :::|| ||.|.....|.:..:.|||.:.|:|:....||    .|:.||:.|.:.|..:.|   :.
  Rat   947 LEERDWLPGQPVLENLSQSIQLSRKTVFVMTQKYAKTE----SFKMAFYLSHQRLMDEKV---DV 1004

  Fly  1142 SVSAEAEDVAELSPYL---KSVPSNRLL------TCDRYFWEKLRYAIPIELSPRGNNYTLDHH- 1196
            .:....|...:.|.:|   |.:.|:.:|      ....|||:.|:.|:           |.|:|
  Rat  1005 IILIFLEKPLQKSKFLQLRKRLCSSSVLEWPTNPQAHPYFWQCLKNAL-----------TTDNHV 1058

  Fly  1197 ---ERFKQPV 1203
               :.||:.|
  Rat  1059 AYSQMFKETV 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380	4/24 (17%)
		leucine-rich repeat	92..115	CDD:275380	6/22 (27%)
		LRR_8	115..181	CDD:290566	25/76 (33%)
		leucine-rich repeat	116..146	CDD:275380	12/39 (31%)
		leucine-rich repeat	147..170	CDD:275380	6/23 (26%)
		leucine-rich repeat	171..201	CDD:275380	8/29 (28%)
		LRR_RI	210..464	CDD:238064	77/282 (27%)
		leucine-rich repeat	212..236	CDD:275380	2/23 (9%)
		LRR_8	235..295	CDD:290566	16/67 (24%)
		leucine-rich repeat	237..260	CDD:275380	6/30 (20%)
		leucine-rich repeat	261..284	CDD:275380	5/22 (23%)
		LRR_8	283..345	CDD:290566	25/77 (32%)
		leucine-rich repeat	285..308	CDD:275380	6/22 (27%)
		leucine-rich repeat	309..334	CDD:275380	13/40 (33%)
		LRR_8	334..393	CDD:290566	24/63 (38%)
		leucine-rich repeat	335..358	CDD:275380	8/22 (36%)
		leucine-rich repeat	359..382	CDD:275380	11/24 (46%)
		LRR_8	382..441	CDD:290566	17/61 (28%)
		leucine-rich repeat	383..406	CDD:275380	5/25 (20%)
		leucine-rich repeat	407..430	CDD:275380	7/22 (32%)
		LRR_8	431..488	CDD:290566	19/56 (34%)
		leucine-rich repeat	431..451	CDD:275380	4/19 (21%)
		leucine-rich repeat	454..477	CDD:275380	9/22 (41%)
		LRR_8	477..559	CDD:290566	23/97 (24%)
		leucine-rich repeat	478..499	CDD:275380	6/27 (22%)
		leucine-rich repeat	502..525	CDD:275380	6/22 (27%)
		leucine-rich repeat	526..548	CDD:275380	4/21 (19%)
		leucine-rich repeat	590..617	CDD:275380	7/26 (27%)
		leucine-rich repeat	618..641	CDD:275380	3/22 (14%)
		leucine-rich repeat	642..689	CDD:275380	5/46 (11%)
		LRRCT	679..736	CDD:214507	12/56 (21%)
		leucine-rich repeat	775..796	CDD:275380	3/20 (15%)
		LRR_8	797..852	CDD:290566	16/55 (29%)
		leucine-rich repeat	797..817	CDD:275380	4/20 (20%)
		leucine-rich repeat	818..841	CDD:275380	7/22 (32%)
		LRR_8	841..900	CDD:290566	14/58 (24%)
		leucine-rich repeat	842..865	CDD:275380	6/22 (27%)
		LRR_4	866..907	CDD:289563	10/45 (22%)
		leucine-rich repeat	866..889	CDD:275380	5/22 (23%)
		leucine-rich repeat	890..911	CDD:275380	5/25 (20%)
		TIR	1045..1183	CDD:214587	43/151 (28%)
Tlr7	XP_017457568.1	leucine-rich repeat	66..87	CDD:275380	4/22 (18%)
		LRR_8	93..157	CDD:290566	19/68 (28%)
		leucine-rich repeat	109..146	CDD:275380	12/39 (31%)
		leucine-rich repeat	147..191	CDD:275380	18/89 (20%)
		leucine-rich repeat	192..223	CDD:275380	6/30 (20%)
		LRR_8	222..277	CDD:290566	18/57 (32%)
		LRR_RI	223..472	CDD:238064	79/272 (29%)
		leucine-rich repeat	224..244	CDD:275380	5/22 (23%)
		leucine-rich repeat	245..268	CDD:275380	6/22 (27%)
		leucine-rich repeat	269..309	CDD:275380	13/40 (33%)
		LRR_8	308..368	CDD:290566	23/59 (39%)
		leucine-rich repeat	310..333	CDD:275380	8/22 (36%)
		leucine-rich repeat	334..359	CDD:275380	11/24 (46%)
		leucine-rich repeat	370..389	CDD:275380	2/18 (11%)
		leucine-rich repeat	390..416	CDD:275380	9/42 (21%)
		leucine-rich repeat	417..440	CDD:275380	10/25 (40%)
		LRR_8	515..573	CDD:290566	20/72 (28%)
		leucine-rich repeat	515..537	CDD:275380	5/24 (21%)
		LRR_RI	532..778	CDD:238064	71/337 (21%)
		leucine-rich repeat	538..562	CDD:275380	9/23 (39%)
		LRR_8	561..627	CDD:290566	20/131 (15%)
		leucine-rich repeat	563..586	CDD:275380	8/44 (18%)
		leucine-rich repeat	587..616	CDD:275380	9/66 (14%)
		leucine-rich repeat	617..639	CDD:275380	9/33 (27%)
		LRR_8	639..706	CDD:290566	17/85 (20%)
		leucine-rich repeat	640..670	CDD:275380	9/48 (19%)
		leucine-rich repeat	671..695	CDD:275380	4/23 (17%)
		LRR_8	694..754	CDD:290566	18/59 (31%)
		leucine-rich repeat	696..719	CDD:275380	7/22 (32%)
		leucine-rich repeat	720..743	CDD:275380	6/22 (27%)
		leucine-rich repeat	768..786	CDD:275380	3/17 (18%)
		TIR	909..1054	CDD:214587	43/162 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780