DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Tlr7

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:XP_017457568.1 Gene:Tlr7 / 317468 RGDID:1563357 Length:1068 Species:Rattus norvegicus


Alignment Length:1245 Identity:292/1245 - (23%)
Similarity:490/1245 - (39%) Gaps:325/1245 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PLDLQVAEAAGRLDLQCSQELLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRL 119
            |.|:.:......:.:.|:.:  |.:|:..|:......|: |.|:  .:..:.|::|..|..|:.|
  Rat    53 PCDVSLDSTNTHVIVDCTDK--HLTEIPEGIPTNTTNLT-LTIN--HIPSISPDSFHRLKHLEEL 112

  Fly   120 TLESHNAVWGP----------GKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMP-SLQL 173
            .|.. |.|  |          .|.|::...||.||.:|..|:|..|.:.::|:    .:| ||||
  Rat   113 DLRC-NCV--PILLGSKANVCTKRLQIRPGSFSGLSDLKSLYLDGNQLLEIPQ----DLPSSLQL 170

  Fly   174 LNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQ 238
            |:|..|.|.|               ::..|                           .|.|..::
  Rat   171 LSLEANNIFS---------------ITKEN---------------------------LSELVNIE 193

  Fly   239 TLSLQHN-------NIS-TLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDL 295
            :|.|..|       |:| ::..:|...:.:|:||::..|::.::|:..   ...|.||:|..|.:
  Rat   194 SLYLGQNCYYRNPCNVSYSIEKDAFLVMKNLKVLSLKDNNVTAVPTIL---PPNLLELYLYNNII 255

  Fly   296 YELPKGLLHRLEQLLVLDLSGNQLTSHHV----------------DNSTFAGLIRLIVLNLSNNA 344
            ..:.:...::|.||.|||||||....::|                ||: |..|..|.||.|.:|:
  Rat   256 KRIQEHDFNKLSQLQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNA-FDSLTELKVLRLHSNS 319

  Fly   345 LTRIGSKTFKELYFLQILDMRNNSIG-HIEEGAFL-PLYNLHTLNLAEN---RLHTLDNRIFNGL 404
            |..:.::.||.:..||.||:..|.:. .|||..|| .|.||..|:|:.|   :::.....:.:.|
  Rat   320 LQHVPAEWFKNMSNLQELDLSQNYLAREIEEAKFLNSLPNLVQLDLSFNYELQVYHASITLPHSL 384

  Fly   405 YVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKN 469
            ..||||   .||  .::...|:   :||:..||         .:.:||.|:.||||.|.|.....
  Rat   385 SSLTKL---KNL--YIKGYVFK---ELKDSSLS---------VLHNLSNLEVLDLGTNFIKIADL 432

  Fly   470 NTFRNLNQLTGLRLIDNRIGNIT-------VGMFQDL--------PR-LSVLNLAKNRIQSIERG 518
            |.|:   |...|:.||..:..|:       ||:..:.        |: |..|:..  |.....|.
  Rat   433 NIFQ---QFENLKFIDLSVNKISPSEESREVGLCPNAQTSVDWHGPQVLEALHYF--RYDEYARS 492

  Fly   519 AFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWF---DYAFIPSNLKWLDIHGNY 580
            ...||.|      ...|| .:|....|....  |:||.|::.:.   |:..: |.||.|::.||.
  Rat   493 CRFKNKE------PPTFL-PLNADCHTYGKT--LDLSRNNIFFIKPSDFKHL-SFLKCLNLSGNA 547

  Fly   581 IEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARV 645
            |....|..:||....:..||.|:||            ::||:          :..|.:...|..:
  Rat   548 IGQTLNGSELQPLRELRYLDFSNNR------------LDLLY----------STAFEELQNLEIL 590

  Fly   646 DLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNI 710
            ||.:|                           .:.|:.    |.:..:.|.|.:       |.::
  Rat   591 DLSSN---------------------------SHYFQA----EGITHMLNFTKK-------LRHL 617

  Fly   711 ECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFH-DATWATN 774
            |.||.:...      .|.|||..:   ||.   :....|:.         ||    | |..|.  
  Rat   618 EKLMMNDND------ISTSASRTM---ESE---SLRVLEFR---------GN----HLDVLWR-- 655

  Fly   775 IVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGR-RNLRALYLNASNLMTLQNGSLAQ 838
              |...:.|....|.:  ::.:|.:..|::..:..|...|. .||..|.|..:.|.:...|.|..
  Rat   656 --DGDNRYLDFFKNLL--NLEELDISRNSLNSVPPGVFEGMPPNLTTLSLAKNGLRSFSWGRLQL 716

  Fly   839 LVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRL--- 900
            |.:|:.|.|.:|:||.:..........|.:|.|::|.:..::....|..:.|..|.:.:|::   
  Rat   717 LKHLKNLDLSHNQLTTVPARLANCSKSLTKLILNHNQIRQLTKYFLEDALQLRYLDISSNKIQVI 781

  Fly   901 --SSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELI 963
              :|.|. ...::|..|.|..|.:.|.|..:..:......:..:...|.|:.|...|..:...:|
  Rat   782 QKTSFPE-NVLNNLNMLLLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCAGPGAHKGQSVI 845

  Fly   964 G------NLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVR 1022
            .      .|    |.::|:..|.| |||                  ::||::|:....:|...  
  Rat   846 SLDLYTCEL----DLTNLILFSVS-ISS------------------VLFLMIVMTTSHLFFWD-- 885

  Fly  1023 MWLFAHY------GVRVCEPRFEDAGKLYDAIILHSEKD---YEFVCRNIAAELEHGRPP-FRLC 1077
            ||...::      |.:    ..:.....|||.|::..|:   .|:|.:.:..:||..|.. |.||
  Rat   886 MWYIYYFWKAKIKGYQ----HLQSMESCYDAFIVYDTKNSAVTEWVLQELVVKLEDPREKHFNLC 946

  Fly  1078 IQQRD-LPPQASHLQLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEET 1141
            :::|| ||.|.....|.:..:.|||.:.|:|:....||    .|:.||:.|.:.|..:.|   :.
  Rat   947 LEERDWLPGQPVLENLSQSIQLSRKTVFVMTQKYAKTE----SFKMAFYLSHQRLMDEKV---DV 1004

  Fly  1142 SVSAEAEDVAELSPYL---KSVPSNRLL------TCDRYFWEKLRYAIPIELSPRGNNYTLDHH- 1196
            .:....|...:.|.:|   |.:.|:.:|      ....|||:.|:.|:           |.|:| 
  Rat  1005 IILIFLEKPLQKSKFLQLRKRLCSSSVLEWPTNPQAHPYFWQCLKNAL-----------TTDNHV 1058

  Fly  1197 ---ERFKQPV 1203
               :.||:.|
  Rat  1059 AYSQMFKETV 1068

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 4/24 (17%)
leucine-rich repeat 92..115 CDD:275380 6/22 (27%)
LRR_8 115..181 CDD:404697 25/76 (33%)
leucine-rich repeat 116..146 CDD:275380 12/39 (31%)
leucine-rich repeat 147..170 CDD:275380 6/23 (26%)
leucine-rich repeat 171..201 CDD:275380 8/29 (28%)
LRR 210..592 CDD:443914 113/429 (26%)
leucine-rich repeat 212..236 CDD:275380 2/23 (9%)
leucine-rich repeat 237..260 CDD:275380 6/30 (20%)
leucine-rich repeat 261..284 CDD:275380 5/22 (23%)
leucine-rich repeat 285..308 CDD:275380 6/22 (27%)
leucine-rich repeat 309..334 CDD:275380 13/40 (33%)
leucine-rich repeat 335..358 CDD:275380 8/22 (36%)
leucine-rich repeat 359..382 CDD:275380 11/24 (46%)
leucine-rich repeat 383..406 CDD:275380 5/25 (20%)
leucine-rich repeat 407..430 CDD:275380 7/22 (32%)
leucine-rich repeat 431..451 CDD:275380 4/19 (21%)
leucine-rich repeat 454..477 CDD:275380 9/22 (41%)
leucine-rich repeat 478..499 CDD:275380 6/27 (22%)
leucine-rich repeat 502..525 CDD:275380 6/22 (27%)
leucine-rich repeat 526..548 CDD:275380 4/21 (19%)
leucine-rich repeat 590..617 CDD:275380 7/26 (27%)
leucine-rich repeat 618..641 CDD:275380 3/22 (14%)
leucine-rich repeat 642..689 CDD:275380 5/46 (11%)
LRRCT 679..736 CDD:214507 12/56 (21%)
LRR <775..>920 CDD:443914 34/150 (23%)
leucine-rich repeat 775..796 CDD:275380 3/20 (15%)
leucine-rich repeat 797..817 CDD:275380 4/20 (20%)
leucine-rich repeat 818..841 CDD:275380 7/22 (32%)
leucine-rich repeat 842..865 CDD:275380 6/22 (27%)
leucine-rich repeat 866..889 CDD:275380 5/22 (23%)
leucine-rich repeat 890..911 CDD:275380 5/25 (20%)
TIR 1045..1183 CDD:214587 43/151 (28%)
Tlr7XP_017457568.1 leucine-rich repeat 66..87 CDD:275380 4/22 (18%)
LRR_8 93..157 CDD:404697 19/68 (28%)
leucine-rich repeat 109..146 CDD:275380 12/39 (31%)
LRR 142..>452 CDD:443914 102/379 (27%)
leucine-rich repeat 147..191 CDD:275380 18/89 (20%)
leucine-rich repeat 192..223 CDD:275380 6/30 (20%)
PLN00113 208..>752 CDD:215061 165/670 (25%)
leucine-rich repeat 224..244 CDD:275380 5/22 (23%)
leucine-rich repeat 245..268 CDD:275380 6/22 (27%)
leucine-rich repeat 269..309 CDD:275380 13/40 (33%)
leucine-rich repeat 310..333 CDD:275380 8/22 (36%)
leucine-rich repeat 334..359 CDD:275380 11/24 (46%)
leucine-rich repeat 370..389 CDD:275380 2/18 (11%)
leucine-rich repeat 390..416 CDD:275380 9/42 (21%)
leucine-rich repeat 417..440 CDD:275380 10/25 (40%)
leucine-rich repeat 515..537 CDD:275380 5/24 (21%)
leucine-rich repeat 538..562 CDD:275380 9/23 (39%)
leucine-rich repeat 563..586 CDD:275380 8/44 (18%)
leucine-rich repeat 587..616 CDD:275380 9/66 (14%)
leucine-rich repeat 617..639 CDD:275380 9/33 (27%)
leucine-rich repeat 640..670 CDD:275380 9/48 (19%)
leucine-rich repeat 671..695 CDD:275380 4/23 (17%)
leucine-rich repeat 696..719 CDD:275380 7/22 (32%)
leucine-rich repeat 720..743 CDD:275380 6/22 (27%)
LRR_8 743..>786 CDD:404697 8/42 (19%)
leucine-rich repeat 768..786 CDD:275380 3/17 (18%)
TIR 909..1054 CDD:214587 43/162 (27%)

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