DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and Tlr13

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	XP_038956543.1	Gene:	Tlr13 / 317227	RGDID:	1562655	Length:	956	Species:	Rattus norvegicus

Alignment Length:	1172	Identity:	275/1172 - (23%)
Similarity:	446/1172 - (38%)	Gaps:	357/1172 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 LPEGV-WCS---MPSLQLLNLT--QNRIRSAEFLGFSE----------KLCAGSALSNANGAVSG 208
            :|:.| .|.   :||||||.:.  .:.:..||..||::          ..|....::|...|:|.
  Rat     1 MPKAVKMCGSSVVPSLQLLLMLIGLSLLSLAETYGFNKCTQYEFDIHHVFCIRKKITNLTEAISD 65

  Fly   209 GSELQT-LDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLV 272
            .....| |:::.|.::.|| .|..:.|..|..|.|:.|.|..:...|..||.:|.:||:..|.:.
  Rat    66 IPRYTTHLNLTNNYIQVLP-PWSFTNLSALVDLRLEWNLIWKIDEGAFRGLENLTLLNLVENKIQ 129

  Fly   273 SLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIV 337
            |: :.:|.|                     |..||.||   ||.||:|  |:....|..|::|..
  Rat   130 SV-NNSFEG---------------------LSNLETLL---LSHNQIT--HIHKDAFTPLVKLKY 167

  Fly   338 LNLSNNALTRIGS--KTFKELYFLQILDMRNNSIGHIE--------------EG--------AFL 378
            |:||.|.::....  :..:.|..|:.||:.||||.:::              ||        :.|
  Rat   168 LSLSRNRISNFSGILEAVQHLPCLEHLDLINNSIMYLDHSPRSLVSLTHLSFEGNNLTELNFSTL 232

  Fly   379 PLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTE 443
            .|.||..|:.::|....:.:.....|..|..|.|:..:|.: |..:.::..:::.:|||:.:|..
  Rat   233 SLPNLTNLSASQNGHGVIQDVYLKTLPQLQSLNLSGTVVKL-EMLSAKHLQNVRVMDLSNRELKH 296

  Fly   444 -------VPEAVQDLSMLKT------------------------LDLGEN-QISEFKNNTFRNLN 476
                   |...:::|.||:.                        ||||:| .:....::.|..|.
  Rat   297 GHLNMKIVCYLLRNLPMLEILFFHKNATNAEGIKQLAKCTRLLFLDLGQNSDLVHLNDSEFNALP 361

  Fly   477 QLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDING 541
            .|..|.|...::..|:...:..|..|::|:|:.|:.:|....||.....:|.:.|.:|.:|::|.
  Rat   362 SLQRLNLNKCQLSFISNKTWSSLQNLTILDLSHNKFKSFPDFAFSPLKRLEFLSLSRNPITELNN 426

  Fly   542 I-FATLASLLWLNLSENHLVWFD-YAFIP-SNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASH 603
            : |:.|.||..|||:...:|..| |:|.. .||:.||:..|.|..| |:...|...::.||..||
  Rat   427 LAFSGLFSLKELNLAACWIVTIDRYSFTQFPNLEVLDLGDNNIRTL-NHGTFQPLKKLHTLILSH 490

  Fly   604 NRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSK------ISLNALRV 662
            ||: ||                     :::|.|...|.|..:||..|.||.      :.|..|.|
  Rat   491 NRL-EI---------------------MESNAFSGLTGLRYLDLMYNSLSYFHKHHFMGLEKLLV 533

  Fly   663 APVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTR--QHPHVVDLGNIECL----MPHS-RSA 720
                       ..||.|            :|...|||  |:|..:.|.:::.|    ..|. :..
  Rat   534 -----------LKLGFN------------KITYETTRTLQYPPFMKLKSLKQLNLEGQKHGIQVV 575

  Fly   721 PLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAA 785
            |......||:..                       |::...|.|.|.|......:::..:.|::.
  Rat   576 PRNFFQGLSSLQ-----------------------ELLLGKNPSVFLDHHQFDPLINLTKLDISG 617

  Fly   786 LPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENN 850
            ..            ||:                |:||||:|   ..||     |..|:||.||||
  Rat   618 TK------------DGD----------------RSLYLNSS---LFQN-----LKRLKVLRLENN 646

  Fly   851 KLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLS-SLPHLQYRHSLQG 914
            .|.:|....|.||..|:...|..|.|..|:.:..|.|.||....:..|:|. :..:|.:::
  Rat   647 NLESLVPGMFSSLQNLQVFSLRFNNLKVINQSHLENLKSLMFFDVYGNKLQCTCDNLWFKN---- 707

  Fly   915 LTLGRNAWSCR-------------CQQLRELAQFVS-DNAMVVRDAHDIYCLDAGIKRELELIGN 965
                   ||..             |||....:..:. |:||...|...:|.|
  Rat   708 -------WSMNTEEVHIPFLRSYPCQQPNSQSLLIDFDDAMCNFDLGKVYFL------------- 752

  Fly   966 LANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMWLFAHYG 1030
                  ||                                |.||:..:||.: .|.:|.....||
  Rat   753 ------CS--------------------------------FSVVLSTMVFSW-FSAKMIASLWYG 778

  Fly  1031 VRVC-----------EPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHG-RPPFRLCIQQRDL 1083
            :.:|           |.:|     ||||.:..|..|..:|.:.:...||.| :..|:||:.|||.
  Rat   779 LYICRAWYLTKWHKTEKKF-----LYDAFVSFSATDEAWVYKELVPALEEGSQTTFKLCLHQRDF 838

  Fly  1084 PPQASHLQLVEGA-RASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEA 1147
            .|.....:.::.| .||||.:.|::.:.|.:||.|:|                |.:....:..|.
  Rat   839 EPGIDIFENIQNAINASRKTLCVVSNHYLHSEWCRLE----------------VQLASMKMFYEH 887

  Fly  1148 EDVAELSPYLKSVPSNRLLTCDR---------------------YFWEKLRYAIPIELSPRGNNY 1191
            :||..|. :|:.:|:.:|.:..|                     .||.::|.|:..|...:.|.:
  Rat   888 KDVIILI-FLEEIPNYKLSSYHRLRKLINRQTFITWPDSAHQQPLFWARIRNALGNETVEKENTH 951

  Fly  1192 TL 1193
            .:
  Rat   952 LI 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566	9/26 (35%)
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380	3/13 (23%)
		leucine-rich repeat	171..201	CDD:275380	9/41 (22%)
		LRR_RI	210..464	CDD:238064	75/310 (24%)
		leucine-rich repeat	212..236	CDD:275380	7/24 (29%)
		LRR_8	235..295	CDD:290566	15/59 (25%)
		leucine-rich repeat	237..260	CDD:275380	8/22 (36%)
		leucine-rich repeat	261..284	CDD:275380	7/22 (32%)
		LRR_8	283..345	CDD:290566	18/61 (30%)
		leucine-rich repeat	285..308	CDD:275380	2/22 (9%)
		leucine-rich repeat	309..334	CDD:275380	10/24 (42%)
		LRR_8	334..393	CDD:290566	21/82 (26%)
		leucine-rich repeat	335..358	CDD:275380	6/24 (25%)
		leucine-rich repeat	359..382	CDD:275380	11/44 (25%)
		LRR_8	382..441	CDD:290566	13/58 (22%)
		leucine-rich repeat	383..406	CDD:275380	4/22 (18%)
		leucine-rich repeat	407..430	CDD:275380	5/22 (23%)
		LRR_8	431..488	CDD:290566	18/88 (20%)
		leucine-rich repeat	431..451	CDD:275380	5/26 (19%)
		leucine-rich repeat	454..477	CDD:275380	8/47 (17%)
		LRR_8	477..559	CDD:290566	24/82 (29%)
		leucine-rich repeat	478..499	CDD:275380	4/20 (20%)
		leucine-rich repeat	502..525	CDD:275380	7/22 (32%)
		leucine-rich repeat	526..548	CDD:275380	7/22 (32%)
		leucine-rich repeat	590..617	CDD:275380	9/26 (35%)
		leucine-rich repeat	618..641	CDD:275380	2/22 (9%)
		leucine-rich repeat	642..689	CDD:275380	12/52 (23%)
		LRRCT	679..736	CDD:214507	13/63 (21%)
		leucine-rich repeat	775..796	CDD:275380	1/20 (5%)
		LRR_8	797..852	CDD:290566	18/54 (33%)
		leucine-rich repeat	797..817	CDD:275380	2/19 (11%)
		leucine-rich repeat	818..841	CDD:275380	9/22 (41%)
		LRR_8	841..900	CDD:290566	22/58 (38%)
		leucine-rich repeat	842..865	CDD:275380	12/22 (55%)
		LRR_4	866..907	CDD:289563	11/41 (27%)
		leucine-rich repeat	866..889	CDD:275380	7/22 (32%)
		leucine-rich repeat	890..911	CDD:275380	4/21 (19%)
		TIR	1045..1183	CDD:214587	40/160 (25%)
Tlr13	XP_038956543.1	leucine-rich repeat	47..69	CDD:275380	4/21 (19%)
		leucine-rich repeat	70..93	CDD:275380	7/23 (30%)
		PLN00113	72..>518	CDD:215061	128/497 (26%)
		leucine-rich repeat	94..117	CDD:275380	8/22 (36%)
		leucine-rich repeat	118..140	CDD:275380	8/43 (19%)
		leucine-rich repeat	141..164	CDD:275380	12/27 (44%)
		leucine-rich repeat	165..190	CDD:275380	6/24 (25%)
		leucine-rich repeat	191..213	CDD:275380	7/21 (33%)
		leucine-rich repeat	214..236	CDD:275380	4/21 (19%)
		leucine-rich repeat	237..260	CDD:275380	4/22 (18%)
		leucine-rich repeat	261..283	CDD:275380	5/22 (23%)
		leucine-rich repeat	338..362	CDD:275380	7/23 (30%)
		PLN00113	360..>710	CDD:215061	115/465 (25%)
		leucine-rich repeat	363..386	CDD:275380	5/22 (23%)
		leucine-rich repeat	387..410	CDD:275380	7/22 (32%)
		leucine-rich repeat	411..434	CDD:275380	7/22 (32%)
		leucine-rich repeat	435..458	CDD:275380	8/22 (36%)
		leucine-rich repeat	459..482	CDD:275380	8/23 (35%)
		leucine-rich repeat	483..506	CDD:275380	10/44 (23%)
		leucine-rich repeat	507..530	CDD:275380	7/22 (32%)
		leucine-rich repeat	531..585	CDD:275380	16/76 (21%)
		leucine-rich repeat	638..661	CDD:275380	12/22 (55%)
		leucine-rich repeat	662..683	CDD:275380	6/20 (30%)
		TIR	799..943	CDD:214587	40/160 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920