DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and Slitrk1

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001100753.1	Gene:	Slitrk1 / 306147	RGDID:	1308858	Length:	696	Species:	Rattus norvegicus

Alignment Length:	786	Identity:	174/786 - (22%)
Similarity:	282/786 - (35%)	Gaps:	262/786 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 HVD--NSTFAGLIRLIV-------LNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFL 378
            |||  ...|..|.|...       |.|..|:|||:....|...|....|.|.||.:..|..||||
  Rat    39 HVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFL 103

  Fly   379 PLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTE 443
                                    ||.::.:|.:|||.:.....|.|....||:.|.
  Rat   104 ------------------------GLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQ-------- 136

  Fly   444 VPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLA 508
                 .|.::|:.:|.|          .|::||:|..|.|.||.|..:...:||.:| ::.|:|.
  Rat   137 -----ADFNLLRDIDPG----------AFQDLNKLEVLILNDNLISTLPANVFQYVP-ITHLDLR 185

  Fly   509 KNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKW 573
            .||::::..               :..|..|.||    |.:|   |.:|  .|.....:.|..:|
  Rat   186 GNRLKTLPY---------------EEVLEQIPGI----AEIL---LEDN--PWDCTCDLLSLKEW 226

  Fly   574 LDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVD 638
            |:                                     ::|        .|.:||::....
  Rat   227 LE-------------------------------------NIP--------KNALIGRVVCEA--- 243

  Fly   639 KTRLARVDLYANVLSKISLNALR-------VAPVSAEK-----PVPEFYLGGNPFECDCSMEWLQ 691
            .|||...||  |..::..|..|:       .||.:.|:     |:|      .||
  Rat   244 PTRLQGKDL--NETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLP------TPF---------- 290

  Fly   692 RINNLTTRQHPHVVDLGNIECLMPHS---RSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQC 753
            :||.......|..|..|..:  :|.:   :..|..|:|:.||.:         .|..|
  Rat   291 KINGQDEHATPGAVPNGGTK--IPGNWQLKIKPTPPIATGSARN---------KPPVH------- 337

  Fly   754 ECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQ--DVSDLYLDGNNMPELEVGHLTGRR 816
              .:.|||.|||.|....... ::|..:::::|.:..|:  :|.:|:|..|.:..:...|....:
  Rat   338 --GLPCPGGCSCDHIPGSGLK-MNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRRSHFVDYK 399

  Fly   817 NLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISN 881
            ||..|.|..:|:..::|.:...|::||.|::::|.|..|...:|..|..|..|.:..|.:..|..
  Rat   400 NLILLDLGNNNIANIENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILP 464

  Fly   882 ATFEPLVSLEVLRLDNNRLSSLP--------------HLQY------------RHSLQGLTLGRN 920
            .||..:..|.:|.|:||.|.|||              |..|            ..|:..:.|..|
  Rat   465 GTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGN 529

  Fly   921 AWSCRCQ--QLRELAQFVSDNAMVVRDAHDIYCLDAGI---KRELELIGN--------------- 965
            .|.|.|.  ..::.|:.:....::    .|:.| :..:   :::..|:.|
  Rat   530 PWECSCTIVPFKQWAERLGSEVLM----SDLKC-ETPVNFFRKDFMLLSNDEICPQLYAKISPTL 589

  Fly   966 ---------LA-NGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFL----VVVLIIVFV 1016
                     || .|...:..||.|..:||            :|...|:|:|:    .||.::||:
  Rat   590 TSHSKNSTGLAETGTHSNSYLDTSRVSIS------------VLVPGLLLVFVTSAFTVVGMLVFI 642

  Fly  1017 FRESVR 1022
            .|...|
  Rat   643 LRNRKR 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380
		LRR_RI	210..464	CDD:238064	38/149 (26%)
		leucine-rich repeat	212..236	CDD:275380
		LRR_8	235..295	CDD:290566
		leucine-rich repeat	237..260	CDD:275380
		leucine-rich repeat	261..284	CDD:275380
		LRR_8	283..345	CDD:290566	9/30 (30%)
		leucine-rich repeat	285..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380	5/12 (42%)
		LRR_8	334..393	CDD:290566	18/65 (28%)
		leucine-rich repeat	335..358	CDD:275380	7/29 (24%)
		leucine-rich repeat	359..382	CDD:275380	9/22 (41%)
		LRR_8	382..441	CDD:290566	11/58 (19%)
		leucine-rich repeat	383..406	CDD:275380	2/22 (9%)
		leucine-rich repeat	407..430	CDD:275380	6/22 (27%)
		LRR_8	431..488	CDD:290566	14/56 (25%)
		leucine-rich repeat	431..451	CDD:275380	2/19 (11%)
		leucine-rich repeat	454..477	CDD:275380	5/22 (23%)
		LRR_8	477..559	CDD:290566	21/81 (26%)
		leucine-rich repeat	478..499	CDD:275380	8/20 (40%)
		leucine-rich repeat	502..525	CDD:275380	4/22 (18%)
		leucine-rich repeat	526..548	CDD:275380	4/21 (19%)
		leucine-rich repeat	590..617	CDD:275380	1/26 (4%)
		leucine-rich repeat	618..641	CDD:275380	3/22 (14%)
		leucine-rich repeat	642..689	CDD:275380	13/58 (22%)
		LRRCT	679..736	CDD:214507	13/59 (22%)
		leucine-rich repeat	775..796	CDD:275380	4/22 (18%)
		LRR_8	797..852	CDD:290566	15/54 (28%)
		leucine-rich repeat	797..817	CDD:275380	4/19 (21%)
		leucine-rich repeat	818..841	CDD:275380	6/22 (27%)
		LRR_8	841..900	CDD:290566	19/58 (33%)
		leucine-rich repeat	842..865	CDD:275380	8/22 (36%)
		LRR_4	866..907	CDD:289563	16/54 (30%)
		leucine-rich repeat	866..889	CDD:275380	6/22 (27%)
		leucine-rich repeat	890..911	CDD:275380	11/46 (24%)
		TIR	1045..1183	CDD:214587
Slitrk1	NP_001100753.1	leucine-rich repeat	39..60	CDD:275380	6/20 (30%)
		leucine-rich repeat	62..83	CDD:275380	7/20 (35%)
		leucine-rich repeat	84..107	CDD:275380	11/46 (24%)
		LRR_8	108..166	CDD:290566	21/80 (26%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		leucine-rich repeat	132..155	CDD:275380	8/45 (18%)
		LRR_8	155..213	CDD:290566	21/82 (26%)
		leucine-rich repeat	156..177	CDD:275380	8/20 (40%)
		TPKR_C2	212..>250	CDD:301599	12/87 (14%)
		leucine-rich repeat	356..372	CDD:275380	2/16 (13%)
		leucine-rich repeat	377..400	CDD:275380	5/22 (23%)
		leucine-rich repeat	401..424	CDD:275380	6/22 (27%)
		LRR_8	425..483	CDD:290566	19/57 (33%)
		leucine-rich repeat	425..448	CDD:275380	8/22 (36%)
		leucine-rich repeat	449..472	CDD:275380	6/22 (27%)
		LRR_8	471..530	CDD:290566	13/58 (22%)
		leucine-rich repeat	473..495	CDD:275380	9/21 (43%)
		leucine-rich repeat	496..520	CDD:275380	2/23 (9%)
		TPKR_C2	529..579	CDD:301599	9/54 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050