DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and Tlr1

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	XP_038947853.1	Gene:	Tlr1 / 305354	RGDID:	1309975	Length:	808	Species:	Rattus norvegicus

Alignment Length:	957	Identity:	219/957 - (22%)
Similarity:	357/957 - (37%)	Gaps:	292/957 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 GLIRLIVLNLS----------NNALTRIGSKTFKELYFLQ--ILDMRNNSIGHIEEGAFLPLYNL 383
            ||| ||.:.||          |..|||:.    |:|. ||  .||:..|:|..::....|.|..|
  Rat    29 GLI-LIKIQLSEESELIIKRPNANLTRVP----KDLP-LQTTTLDVSQNNISELQTSDILLLSKL 87

  Fly   384 HTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVP--E 446
            ....::.|||..|:..:|.....|..|.|::|.:.::...|   .:|||.||||.|....:|  :
  Rat    88 RVFIMSYNRLQYLNISVFKFNTELEYLDLSHNELRLISCHA---TADLKHLDLSFNAFDALPICK 149

  Fly   447 AVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQD---LPRLS----- 503
            ...:||.|:.|.|..:||.........:|| ::.:.|:   :|: |.|..:|   |..:|
  Rat   150 EFGNLSQLQFLGLSGSQIQNSSVQLIAHLN-ISKVLLV---LGD-TYGEKEDPKCLQHISTETLH 209

  Fly   504 -----------VLNLAKNRIQSIERGAFDKNTEIEAIRLDKN---FLTDINGIFAT--LASLLWL 552
                       :|:::.:...|:|.      :.|:.:..|||   ||..:..:..|  |::|...
  Rat   210 IVFPSKREFHFLLDMSVSTAISLEL------SNIKCVLEDKNCSYFLGTLERLRKTQRLSNLTLN 268

  Fly   553 NLSEN--------HLVWFD--YAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRIT 607
            |:...        .|||..  .:|..||:| |..|.|:    ..::.....:|..::   |..:|
  Rat   269 NVDTTWNSFINILQLVWHTPVKSFSISNVK-LKGHFNF----RRFHYSDTSLRALSI---HQVVT 325

  Fly   608 EIGAMSVPNS-IELLFINNNIIGQIQANTFVDKTRLAR------------VDLYANVLSKISL-- 657
            ::  .|.|.| |..:|.|.|    ||:.| |..||:..            :|...|:|:.|..
  Rat   326 DV--FSFPQSNIYSIFSNMN----IQSFT-VSGTRMVHMLCPDQISPFLYLDFTDNLLTDIVFED 383

  Fly   658 --NALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSA 720
              |.:|:..:|.:|                        |.|.|        |.|| .||    |.
  Rat   384 CRNLIRLKTLSLQK------------------------NQLKT--------LENI-ILM----SM 411

  Fly   721 PLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAA 785
            .:..|..|..|....:|.....|                   ||      |..::
  Rat   412 EMTSLQKLDISQNSLRYSDAGSP-------------------CS------WTQSL---------- 441

  Fly   786 LPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLN-ASNLMTLQNGSLAQLV--NLRVLHL 847
                                               |.|| :||::|   .|:.:.:  .::||.|
  Rat   442 -----------------------------------LVLNLSSNMLT---DSVFRCLPPKVKVLDL 468

  Fly   848 ENNKLTALEGTEFRSLGLLRELYLHNNMLTHISN-ATFEPLVSLEVLRLDNNRLS--SLPHLQYR 909
            .||::.:: ..:...|..|:||.:.:|.||.:.. ..|.   ||.||.:|:|.:|  |....|..
  Rat   469 HNNRIVSI-SKDVTHLQALQELNVASNFLTDLPGCGAFS---SLSVLVIDHNSVSHPSSDFFQSC 529

  Fly   910 HSLQGLTLGRNAWSCRCQQLRELAQFVSD----NAMVVRDAHDIYCLDAGIKRELELIGNLANGP 970
            .:::.:|.|.|.:.|.|    ||.:||.:    :..||....|.|..|.               |
  Rat   530 QNIRSITAGNNPFRCTC----ELREFVKNIGQASREVVEGWPDSYRCDY---------------P 575

  Fly   971 DC---SDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRM-WLFAHYGV 1031
            |.   :.|.|...|.:|....|   ..:.:.|.:|:|..:...|.:.|.....:|| |.:.....
  Rat   576 DSIKGTPLQDFHMSPLSCDTIL---LTVTIGATLLLLAAIGASLCLYFDLPWYLRMLWQWTQTRH 637

  Fly  1032 RVCEPRFEDAGK--LYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHLQ-LV 1093
            |......|:..:  .:.|.:.:|..|..:|...:...||  :...|:|:.:|:..|..|.:: ::
  Rat   638 RARNIPLEELQRNLQFHAFVSYSGHDSAWVKNELLPNLE--KDDIRVCLHERNFVPGKSIVENII 700

  Fly  1094 EGARASRKIILVLTRNLLATEWNRIEF----RNAFHESLRGLAQKLVIIEETSVSAEAEDVAELS 1154
            .....|.|.|.||:.:.:.:||...|.    .|.|||....|.  |:::|            .:.
  Rat   701 HFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLI--LILLE------------PIP 751

  Fly  1155 PYLKSVPSN----RLLTCDR-------------YFWEKLRYAIPIEL 1184
            .|  |:|:|    :.|...|             .||..||.:|.::|
  Rat   752 QY--SIPTNYHKLKTLMARRTYLEWPTEKSKHGLFWANLRASINVKL 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380
		LRR_RI	210..464	CDD:238064	46/146 (32%)
		leucine-rich repeat	212..236	CDD:275380
		LRR_8	235..295	CDD:290566
		leucine-rich repeat	237..260	CDD:275380
		leucine-rich repeat	261..284	CDD:275380
		LRR_8	283..345	CDD:290566	8/23 (35%)
		leucine-rich repeat	285..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380	2/2 (100%)
		LRR_8	334..393	CDD:290566	20/70 (29%)
		leucine-rich repeat	335..358	CDD:275380	10/32 (31%)
		leucine-rich repeat	359..382	CDD:275380	8/24 (33%)
		LRR_8	382..441	CDD:290566	19/58 (33%)
		leucine-rich repeat	383..406	CDD:275380	6/22 (27%)
		leucine-rich repeat	407..430	CDD:275380	5/22 (23%)
		LRR_8	431..488	CDD:290566	18/58 (31%)
		leucine-rich repeat	431..451	CDD:275380	8/21 (38%)
		leucine-rich repeat	454..477	CDD:275380	6/22 (27%)
		LRR_8	477..559	CDD:290566	20/113 (18%)
		leucine-rich repeat	478..499	CDD:275380	5/23 (22%)
		leucine-rich repeat	502..525	CDD:275380	4/38 (11%)
		leucine-rich repeat	526..548	CDD:275380	8/26 (31%)
		leucine-rich repeat	590..617	CDD:275380	5/26 (19%)
		leucine-rich repeat	618..641	CDD:275380	8/22 (36%)
		leucine-rich repeat	642..689	CDD:275380	8/62 (13%)
		LRRCT	679..736	CDD:214507	12/56 (21%)
		leucine-rich repeat	775..796	CDD:275380	0/20 (0%)
		LRR_8	797..852	CDD:290566	12/57 (21%)
		leucine-rich repeat	797..817	CDD:275380	0/19 (0%)
		leucine-rich repeat	818..841	CDD:275380	7/25 (28%)
		LRR_8	841..900	CDD:290566	19/59 (32%)
		leucine-rich repeat	842..865	CDD:275380	6/22 (27%)
		LRR_4	866..907	CDD:289563	15/43 (35%)
		leucine-rich repeat	866..889	CDD:275380	7/23 (30%)
		leucine-rich repeat	890..911	CDD:275380	8/22 (36%)
		TIR	1045..1183	CDD:214587	37/159 (23%)
Tlr1	XP_038947853.1	PRK15370	<51..>146	CDD:185268	32/102 (31%)
		leucine-rich repeat	63..86	CDD:275378	6/22 (27%)
		leucine-rich repeat	87..110	CDD:275378	6/22 (27%)
		leucine-rich repeat	111..125	CDD:275378	4/13 (31%)
		leucine-rich repeat	132..156	CDD:275378	9/23 (39%)
		leucine-rich repeat	157..169	CDD:275378	5/11 (45%)
		PRK15370	<313..>500	CDD:185268	60/307 (20%)
		leucine-rich repeat	368..389	CDD:275380	5/20 (25%)
		leucine-rich repeat	390..415	CDD:275380	11/61 (18%)
		leucine-rich repeat	416..440	CDD:275380	8/48 (17%)
		leucine-rich repeat	441..462	CDD:275380	7/68 (10%)
		leucine-rich repeat	463..485	CDD:275380	6/22 (27%)
		leucine-rich repeat	486..507	CDD:275380	7/23 (30%)
		leucine-rich repeat	508..531	CDD:275380	8/22 (36%)
		LRRCT	540..594	CDD:214507	18/72 (25%)
		TIR	652..795	CDD:214587	37/160 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920