DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and Tlr6

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_997487.1	Gene:	Tlr6 / 305353	RGDID:	1303030	Length:	806	Species:	Rattus norvegicus

Alignment Length:	885	Identity:	197/885 - (22%)
Similarity:	318/885 - (35%)	Gaps:	279/885 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   434 LDLSSNQLTEVPEAVQDLS-MLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQ 497
            :|.|:..||.||   :||| ..|:|.|.:|.||:.:.:....|::|..|||..|||..:..|:|.
  Rat    47 VDYSNKNLTHVP---KDLSPSTKSLSLSQNSISDLQMSDISFLSELRVLRLSHNRIRRLDFGVFL 108

  Fly   498 DLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWF 562
            ....|..|:::.|::|                                       |:|...:|
  Rat   109 LNRDLEYLDVSHNQLQ---------------------------------------NISCCPMV-- 132

  Fly   563 DYAFIPSNLKWLDIHGNYIEAL------GNYYKLQ-------EEIRVTTLDASHNRIT------- 607
                   |||.||:..|..|.|      ||..||.       :..::..|..||..::
  Rat   133 -------NLKHLDLSFNDFEVLPVYKEFGNLRKLSFLGLSAAKFRQLDLLPISHLHLSCVLLDLV 190

  Fly   608 -------EIGAMSVPNS--IELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVA 663
                   |..::.|||:  :.|:|..|::. .:|.|                    ||:|||...
  Rat   191 NYQIKDGETESLQVPNTNVLHLVFHPNSLF-SVQVN--------------------ISVNALGCL 234

  Fly   664 PVSAEKPVPEFYLGGNPFECDCSMEWLQRIN------NLTTRQHPHVVDLGNIECLMPHSRSAPL 722
            .:|..|.        |...|...:.:|..:.      |||. ||...    |.:|.:...:....
  Rat   235 QLSNIKL--------NDENCQSLIIFLSELTRGPTLLNLTL-QHIET----NWKCFVRLLQFLWP 286

  Fly   723 RPL-----------ASLSASDFV--------CKYESHC--------------------------- 741
            ||:           .|:|...|:        .|.| |.
  Rat   287 RPVEYLNIYNLTITESISRETFIYVETVLKSLKIE-HVTNQVFLFVKDALYSVFAEMNIRMLTLS 350

  Fly   742 -PPTCHCCEYEQCECEVICPGNCSCFHDATWATNI----VDCGRQDLAALPNRIPQ--DVSDLY- 798
             .|..|          ::||...|.|....:..|:    :..|...|..|...|.|  .:.:|:
  Rat   351 DTPFIH----------MVCPEFPSTFAFLNFTQNVFTDSIFQGCSTLKRLETLILQRNGLKNLFK 405

  Fly   799 --LDGNNMPELEV---------GHLTGR-----RNLRALYLNASNLMTLQNGSLAQLV--NLRVL 845
              |....|..||.         .|:..|     .::|.|.| :||::   :.|:.:.:  .::||
  Rat   406 VALMTKTMSSLETLDVSLNSLNSHVYDRTCAWAESIRVLNL-SSNVL---SDSVFRCLPPKVKVL 466

  Fly   846 HLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISN-ATFEPLVSLEVLRLDNNRLS--SLPHLQ 907
            .|.||::.::. .:...|..|:||.:.:|.||.:.. ..|.   ||.||.:|:|.:|  |....|
  Rat   467 DLHNNRIVSIP-KDVTHLQALQELNVASNFLTDLPGCGAFS---SLSVLVIDHNSVSHPSSDFFQ 527

  Fly   908 YRHSLQGLTLGRNAWSCRCQQLRELAQFVSD----NAMVVRDAHDIYCLDAGIKRELELIGNLAN 968
            ...:::.:|.|.|.:.|.|    ||.:||.:    :..||....|.|..|.
  Rat   528 SCQNIRSITAGNNPFRCTC----ELREFVKNIGQASREVVEGWPDSYRCDY-------------- 574

  Fly   969 GPDC---SDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRM-WLFAHY 1029
             ||.   :.|.|...|.:|....|   ..:.:.|.:|:|..:...|.:.|.....:|| |.:...
  Rat   575 -PDSIKGTPLQDFHMSPLSCDTIL---LTVTIGATLLLLAAIGASLCLYFDLPWYLRMLWQWTQT 635

  Fly  1030 GVRVCEPRFEDAGK--LYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHLQ- 1091
            ..|......|:..:  .:.|.:.:||.|..:|...:...||  :...|:|:.:|:..|..|.::
  Rat   636 RHRARNIPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLE--KDDIRVCLHERNFVPGKSIVEN 698

  Fly  1092 LVEGARASRKIILVLTRNLLATEWNRIEF----RNAFHESLRGLAQKLVIIEETSVSAEAEDVAE 1152
            ::.....|.|.|.||:.:.:.:||...|.    .|.|||....|.  |:::|....:
  Rat   699 IIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLI--LILLEPIQQN-------- 753

  Fly  1153 LSPYLKSVPSN----RLLTCDRYFWEKLRYAIPIELSPRG 1188
                  ::||.    |.|...|.:.|     .|||...||
  Rat   754 ------NIPSRYHKLRALMAQRTYLE-----WPIEKGKRG 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380
		LRR_RI	210..464	CDD:238064	13/30 (43%)
		leucine-rich repeat	212..236	CDD:275380
		LRR_8	235..295	CDD:290566
		leucine-rich repeat	237..260	CDD:275380
		leucine-rich repeat	261..284	CDD:275380
		LRR_8	283..345	CDD:290566
		leucine-rich repeat	285..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		LRR_8	334..393	CDD:290566
		leucine-rich repeat	335..358	CDD:275380
		leucine-rich repeat	359..382	CDD:275380
		LRR_8	382..441	CDD:290566	2/6 (33%)
		leucine-rich repeat	383..406	CDD:275380
		leucine-rich repeat	407..430	CDD:275380
		LRR_8	431..488	CDD:290566	21/54 (39%)
		leucine-rich repeat	431..451	CDD:275380	6/16 (38%)
		leucine-rich repeat	454..477	CDD:275380	7/22 (32%)
		LRR_8	477..559	CDD:290566	15/81 (19%)
		leucine-rich repeat	478..499	CDD:275380	9/20 (45%)
		leucine-rich repeat	502..525	CDD:275380	4/22 (18%)
		leucine-rich repeat	526..548	CDD:275380	0/21 (0%)
		leucine-rich repeat	590..617	CDD:275380	7/47 (15%)
		leucine-rich repeat	618..641	CDD:275380	5/22 (23%)
		leucine-rich repeat	642..689	CDD:275380	9/46 (20%)
		LRRCT	679..736	CDD:214507	15/81 (19%)
		leucine-rich repeat	775..796	CDD:275380	5/26 (19%)
		LRR_8	797..852	CDD:290566	18/73 (25%)
		leucine-rich repeat	797..817	CDD:275380	7/36 (19%)
		leucine-rich repeat	818..841	CDD:275380	6/24 (25%)
		LRR_8	841..900	CDD:290566	19/59 (32%)
		leucine-rich repeat	842..865	CDD:275380	6/22 (27%)
		LRR_4	866..907	CDD:289563	15/43 (35%)
		leucine-rich repeat	866..889	CDD:275380	7/23 (30%)
		leucine-rich repeat	890..911	CDD:275380	8/22 (36%)
		TIR	1045..1183	CDD:214587	34/146 (23%)
Tlr6	NP_997487.1	leucine-rich repeat	46..64	CDD:275380	9/19 (47%)
		leucine-rich repeat	65..88	CDD:275378	7/22 (32%)
		LRR_8	87..144	CDD:290566	22/104 (21%)
		leucine-rich repeat	89..112	CDD:275378	9/22 (41%)
		leucine-rich repeat	113..133	CDD:275378	7/67 (10%)
		leucine-rich repeat	134..158	CDD:275378	9/23 (39%)
		leucine-rich repeat	369..385	CDD:275380	2/15 (13%)
		LRR_RI	<380..>500	CDD:238064	30/124 (24%)
		LRR_8	388..451	CDD:290566	15/63 (24%)
		leucine-rich repeat	390..415	CDD:275380	6/24 (25%)
		leucine-rich repeat	416..440	CDD:275380	4/23 (17%)
		leucine-rich repeat	441..462	CDD:275380	6/24 (25%)
		LRR_8	461..516	CDD:290566	18/58 (31%)
		leucine-rich repeat	463..485	CDD:275380	6/22 (27%)
		leucine-rich repeat	486..508	CDD:275380	7/24 (29%)
		leucine-rich repeat	510..531	CDD:275380	7/20 (35%)
		LRRCT	540..594	CDD:214507	18/72 (25%)
		TIR	652..791	CDD:214587	38/154 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820