DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and Nrros

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001020166.1 Gene:Nrros / 303875 RGDID:1310771 Length:692 Species:Rattus norvegicus


Alignment Length:899 Identity:208/899 - (23%)
Similarity:309/899 - (34%) Gaps:314/899 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   193 LCAG---------SALSNANGAVSGGSEL--QTLDVSFNELRSLPDAWGA-SRLRRLQTLSLQHN 245
            ||.|         |....|..|..||.::  :..|.....|.|:|....| ||:     |.|..|
  Rat     8 LCLGFHFLIVEWRSGRGTATAASQGGCKVVDRVADCRSLNLASVPSGLPAHSRM-----LVLDAN 67

  Fly   246 NISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDL---YELPKGLLHRLE 307
            .:..|..::|.....|..|::...||..:...||.....|:.|.|..|.|   |:.....||.|.
  Rat    68 PLRVLWNHSLQAYPRLEDLSLHSCHLDRISHWAFHEQGHLQNLVLADNRLSENYKESATALHTLL 132

  Fly   308 QLLVLDLSGNQLTSHHVDNST--FAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIG 370
            :|..||||||.||.   |.:.  ...|..|.|::|:.|.|.|:....|:.|..|..||::.|.|.
  Rat   133 RLRRLDLSGNSLTE---DMAALMLQNLSSLEVVSLARNTLMRLDDSVFEGLERLVELDLQRNYIF 194

  Fly   371 HIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIV-------ESQAFRNC 428
            .||.|||..|..|..||||.|.|..:.:      :.||:|...|...:|:       |..||   
  Rat   195 EIEGGAFDGLTELRRLNLAYNNLPCIVD------FSLTQLRFLNVSYNILEWFLAAREEAAF--- 250

  Fly   429 SDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKN--NTFRNLNQLTGLRLIDNRIGNI 491
             :|:.||||.|||...| .:.....|.||.|.:|.:..::.  ||......:....|:|..:.||
  Rat   251 -ELEILDLSHNQLLFFP-LLPQCGKLHTLLLQDNSMGFYRELYNTSSPQEMVAQFLLVDGNVTNI 313

  Fly   492 -TVGMFQ-----DLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDIN---------- 540
             ||.:::     ||..|..|::::|:::.:..|...|...:..:.|::|.||.::          
  Rat   314 TTVSLWEEFSSSDLSALRFLDMSQNQLRHLPDGFLKKTPSLSHLNLNQNCLTKLHIREHEPPGAL 378

  Fly   541 -----------------GIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYY 588
                             |:..:|.:|...|||.|.|:.     :|:.|                 
  Rat   379 TELDLSRNQLAELHLAPGLTGSLKNLRVFNLSSNQLLG-----VPTGL----------------- 421

  Fly   589 KLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLS 653
             ......:||||.|||:|:     ..|.::                                   
  Rat   422 -FHSASSITTLDMSHNQIS-----LCPQTV----------------------------------- 445

  Fly   654 KISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSR 718
                      |:..|:|            ..|                   ||..|:        
  Rat   446 ----------PLDWEEP------------SSC-------------------VDFRNM-------- 461

  Fly   719 SAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDL 783
             |.||.|                                                ::..||.:.|
  Rat   462 -ASLRSL------------------------------------------------SLDGCGLKAL 477

  Fly   784 AALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQL----VNLRV 844
            ...|           ..|.::..|::....|                :.|||::.|    ..|:|
  Rat   478 QDCP-----------FQGTSLTHLDLSSNWG----------------ILNGSVSPLSAVAPTLQV 515

  Fly   845 LHLENNKL-TALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHL-- 906
            |.|.|..| :.....:|...|.||||.|..|.||  |...|:...:|:.|.|..|.|::||..  
  Rat   516 LSLRNVGLGSGAAEMDFSGFGNLRELDLSGNSLT--SFPKFKGSSALQTLDLRRNSLTALPQRVV 578

  Fly   907 --QYRHSLQGLTLGRNAWSCRC--QQLRELAQF--VSDNAMVVRDAHDIYC-LDAGIKRELEL-- 962
              |....||.:.|.:|.:.| |  :....|..|  ::|.:||.       | |.:.|.|.:||  
  Rat   579 SEQPLRGLQTIYLSQNPYDC-CGVEGWGALQHFKTIADLSMVT-------CNLSSKIIRVVELPE 635

  Fly   963 -------IGNLANG--------PDCSDLLDASASNISSSQDLAGGYRLPLLAAV 1001
                   .|.:..|        |.|..||.||.....:       ::.|||..:
  Rat   636 GIPQDCKWGQVDTGLFYLVLILPSCLTLLVASTVIFLT-------FKKPLLQVI 682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:404697
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380 4/16 (25%)
LRR 210..592 CDD:443914 115/431 (27%)
leucine-rich repeat 212..236 CDD:275380 7/26 (27%)
leucine-rich repeat 237..260 CDD:275380 5/22 (23%)
leucine-rich repeat 261..284 CDD:275380 6/22 (27%)
leucine-rich repeat 285..308 CDD:275380 9/25 (36%)
leucine-rich repeat 309..334 CDD:275380 11/26 (42%)
leucine-rich repeat 335..358 CDD:275380 8/22 (36%)
leucine-rich repeat 359..382 CDD:275380 11/22 (50%)
leucine-rich repeat 383..406 CDD:275380 7/22 (32%)
leucine-rich repeat 407..430 CDD:275380 8/29 (28%)
leucine-rich repeat 431..451 CDD:275380 9/19 (47%)
leucine-rich repeat 454..477 CDD:275380 7/24 (29%)
leucine-rich repeat 478..499 CDD:275380 6/26 (23%)
leucine-rich repeat 502..525 CDD:275380 5/22 (23%)
leucine-rich repeat 526..548 CDD:275380 6/48 (13%)
leucine-rich repeat 590..617 CDD:275380 9/26 (35%)
leucine-rich repeat 618..641 CDD:275380 0/22 (0%)
leucine-rich repeat 642..689 CDD:275380 4/46 (9%)
LRRCT 679..736 CDD:214507 8/56 (14%)
LRR <775..>920 CDD:443914 40/153 (26%)
leucine-rich repeat 775..796 CDD:275380 4/20 (20%)
leucine-rich repeat 797..817 CDD:275380 3/19 (16%)
leucine-rich repeat 818..841 CDD:275380 4/26 (15%)
leucine-rich repeat 842..865 CDD:275380 7/23 (30%)
leucine-rich repeat 866..889 CDD:275380 10/22 (45%)
leucine-rich repeat 890..911 CDD:275380 8/24 (33%)
TIR 1045..1183 CDD:214587
NrrosNP_001020166.1 leucine-rich repeat 39..57 CDD:275380 4/17 (24%)
LRR 1. /evidence=ECO:0000255 58..79 7/25 (28%)
leucine-rich repeat 60..82 CDD:275380 6/26 (23%)
LRR 2. /evidence=ECO:0000255 82..103 6/20 (30%)
leucine-rich repeat 83..106 CDD:275380 6/22 (27%)
LRR 3. /evidence=ECO:0000255 106..127 6/20 (30%)
leucine-rich repeat 107..158 CDD:275380 20/53 (38%)
LRR 4. /evidence=ECO:0000255 133..155 10/24 (42%)
LRR <140..414 CDD:443914 81/287 (28%)
LRR 5. /evidence=ECO:0000255 158..179 7/20 (35%)
leucine-rich repeat 159..182 CDD:275380 8/22 (36%)
LRR 6. /evidence=ECO:0000255 182..203 10/20 (50%)
leucine-rich repeat 183..206 CDD:275380 11/22 (50%)
LRR 7. /evidence=ECO:0000255 206..227 8/26 (31%)
leucine-rich repeat 207..251 CDD:275380 15/53 (28%)
LRR 8. /evidence=ECO:0000255 228..239 3/10 (30%)
LRR 9. /evidence=ECO:0000255 251..272 9/21 (43%)
leucine-rich repeat 252..273 CDD:275380 9/21 (43%)
LRR 10. /evidence=ECO:0000255 273..294 6/20 (30%)
leucine-rich repeat 274..329 CDD:275380 15/54 (28%)
LRR 293..>595 CDD:443914 88/491 (18%)
LRR 11. /evidence=ECO:0000255 329..350 4/20 (20%)
leucine-rich repeat 330..353 CDD:275380 5/22 (23%)
LRR 12. /evidence=ECO:0000255 353..374 4/20 (20%)
leucine-rich repeat 354..377 CDD:275380 4/22 (18%)
LRR 13. /evidence=ECO:0000255 377..398 1/20 (5%)
leucine-rich repeat 378..403 CDD:275380 2/24 (8%)
LRR 14. /evidence=ECO:0000255 403..424 8/43 (19%)
leucine-rich repeat 404..427 CDD:275380 8/45 (18%)
LRR 15. /evidence=ECO:0000255 427..448 10/70 (14%)
leucine-rich repeat 428..463 CDD:275380 16/124 (13%)
LRR 16. /evidence=ECO:0000255 463..484 7/79 (9%)
leucine-rich repeat 464..486 CDD:275380 8/80 (10%)
LRR 17. /evidence=ECO:0000255 486..507 5/36 (14%)
leucine-rich repeat 487..512 CDD:275380 6/40 (15%)
LRR 18. /evidence=ECO:0000255 512..533 6/20 (30%)
leucine-rich repeat 513..537 CDD:275380 7/23 (30%)
LRR 19. /evidence=ECO:0000255 537..558 10/22 (45%)
leucine-rich repeat 538..559 CDD:275380 10/22 (45%)
LRR 20. /evidence=ECO:0000255 559..580 7/20 (35%)
LRR 21. /evidence=ECO:0000255 585..605 6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.