DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Tlr4

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_062051.2 Gene:Tlr4 / 29260 RGDID:3870 Length:835 Species:Rattus norvegicus


Alignment Length:1084 Identity:236/1084 - (21%)
Similarity:397/1084 - (36%) Gaps:368/1084 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 DNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVS 218
            |.|:.::|..:..|..:|.|.......:||..|..|                    |:||.||:|
  Rat    41 DQNLSKIPHDIPYSTKNLDLSFNPLKILRSYSFSNF--------------------SQLQWLDLS 85

  Fly   219 FNELRSLPD-AWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGN 282
            ..|:.::.| ||..  |.:|.||.|..|.|.:.:|.:.:||::|       .:||::        
  Rat    86 RCEIETIEDKAWHG--LNQLSTLVLTGNPIKSFSPGSFSGLTNL-------ENLVAV-------- 133

  Fly   283 KELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNS-----TFAGLIRLIVLNLSN 342
             |.:...|:|..:     |.|..|::|.|         :|::.:|     .|:.|..|..::||.
  Rat   134 -ETKMTSLEGFHI-----GQLISLKKLNV---------AHNLIHSFKLPEYFSNLTNLEHVDLSY 183

  Fly   343 NALTRIGSKTFKELYFLQ-------ILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRI 400
            |.:..|   :.|:|.||:       .||:..|.|..|:..||..: .||.|.|..|         
  Rat   184 NYIQTI---SVKDLQFLRENPQVNLSLDLSLNPIDSIQAQAFQGI-RLHELTLRSN--------- 235

  Fly   401 FNGLYVLTKLTLNN----NLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGE 461
            ||...|| |:.|.|    ::..::..: |:|..:|:..|.|      |.|.:.::|         
  Rat   236 FNSSNVL-KMCLQNMTGLHVHRLILGE-FKNERNLESFDRS------VMEGLCNVS--------- 283

  Fly   462 NQISEFK-------NNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPR------LSVLNLAKNRIQ 513
              |.||:       ::...|||.|..:..:.  ...:.:....|:||      ||::........
  Rat   284 --IDEFRLTYINHFSDDIYNLNCLANISAMS--FTGVHIKHIADVPRHFKWQSLSIIRCHLKPFP 344

  Fly   514 SIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVW---FDYA-FIPSNLKWL 574
            .:.. .|.|:..:...|.|.:|     |..| |.||.:|:||.|.:.:   ..|: |..:|||:|
  Rat   345 KLSL-PFLKSWTLTTNREDISF-----GQLA-LPSLRYLDLSRNAMSFRGCCSYSDFGTNNLKYL 402

  Fly   575 DIHGNYIEAL-GNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIE-LLFINNNIIGQIQANTFV 637
            |:..|.:..: .|:..|:|   :..||..|:.:.::...||..|:| ||:::.:     ..||  
  Rat   403 DLSFNGVILMSANFMGLEE---LEYLDFQHSTLKKVTEFSVFLSLEKLLYLDIS-----YTNT-- 457

  Fly   638 DKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHP 702
                  ::|.....|..||||.|::|              ||.|:.:..........|||     
  Rat   458 ------KIDFDGIFLGLISLNTLKMA--------------GNSFKDNTLSNVFTNTTNLT----- 497

  Fly   703 HVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFH 767
             .:||..                                      |:.||               
  Rat   498 -FLDLSK--------------------------------------CQLEQ--------------- 508

  Fly   768 DATWATNIVDCGRQDLAALPNRIPQDVSD-LYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTL 831
                                  |.:.|.| ||                  .|:.|.::.:||:.|
  Rat   509 ----------------------ISRGVFDTLY------------------RLQLLNMSHNNLLFL 533

  Fly   832 QNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLD 896
            ......||.:||.|....|::...:|                 :|.|...       ||.|..|.
  Rat   534 DPSHYKQLYSLRTLDCSFNRIETSKG-----------------ILQHFPK-------SLAVFNLT 574

  Fly   897 NNRLSSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELE 961
            ||.:                      :|.| :.:...|:|.|..|.:.:...:.|. :.|..:..
  Rat   575 NNSV----------------------ACIC-EYQNFLQWVKDQKMFLVNVEQMKCA-SPIDMKAS 615

  Fly   962 LIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMWLF 1026
            |:.:..|. .|                    |....:.:|.|:..|||..:...::.....:.|.
  Rat   616 LVLDFTNS-TC--------------------YIYKTIISVSVVSVLVVATVAFLIYHFYFHLILI 659

  Fly  1027 AHYGVRVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPP----QA 1087
            |.     |: ::.....:|||.:::|.::.::|...:...||.|.|.|:||:..||..|    .|
  Rat   660 AG-----CK-KYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAA 718

  Fly  1088 SHLQLVEGARASRKIILVLTRNLLATEWNRIEFRNA----FHESLRGLAQKLVIIEETSVSAEAE 1148
            :.:|  ||...|||:|:|::|:.:.:.|...|:..|    |..|..|:.  .:::|:        
  Rat   719 NIIQ--EGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGII--FIVLEK-------- 771

  Fly  1149 DVAELSPYLKSVPSNRLLTCDRY------------FWEKLRYAI 1180
              .|.|...:.|...|||:.:.|            ||.:|:.|:
  Rat   772 --VEKSLLRQQVELYRLLSRNTYLEWEDNALGRHIFWRRLKKAL 813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566 6/26 (23%)
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380 4/15 (27%)
leucine-rich repeat 171..201 CDD:275380 6/29 (21%)
LRR_RI 210..464 CDD:238064 71/270 (26%)
leucine-rich repeat 212..236 CDD:275380 10/24 (42%)
LRR_8 235..295 CDD:290566 15/59 (25%)
leucine-rich repeat 237..260 CDD:275380 9/22 (41%)
leucine-rich repeat 261..284 CDD:275380 3/22 (14%)
LRR_8 283..345 CDD:290566 16/66 (24%)
leucine-rich repeat 285..308 CDD:275380 5/22 (23%)
leucine-rich repeat 309..334 CDD:275380 6/29 (21%)
LRR_8 334..393 CDD:290566 21/65 (32%)
leucine-rich repeat 335..358 CDD:275380 7/22 (32%)
leucine-rich repeat 359..382 CDD:275380 8/29 (28%)
LRR_8 382..441 CDD:290566 17/62 (27%)
leucine-rich repeat 383..406 CDD:275380 7/22 (32%)
leucine-rich repeat 407..430 CDD:275380 6/26 (23%)
LRR_8 431..488 CDD:290566 13/63 (21%)
leucine-rich repeat 431..451 CDD:275380 5/19 (26%)
leucine-rich repeat 454..477 CDD:275380 5/29 (17%)
LRR_8 477..559 CDD:290566 20/87 (23%)
leucine-rich repeat 478..499 CDD:275380 1/20 (5%)
leucine-rich repeat 502..525 CDD:275380 4/22 (18%)
leucine-rich repeat 526..548 CDD:275380 6/21 (29%)
leucine-rich repeat 590..617 CDD:275380 7/26 (27%)
leucine-rich repeat 618..641 CDD:275380 5/23 (22%)
leucine-rich repeat 642..689 CDD:275380 11/46 (24%)
LRRCT 679..736 CDD:214507 7/56 (13%)
leucine-rich repeat 775..796 CDD:275380 2/20 (10%)
LRR_8 797..852 CDD:290566 13/54 (24%)
leucine-rich repeat 797..817 CDD:275380 2/19 (11%)
leucine-rich repeat 818..841 CDD:275380 7/22 (32%)
LRR_8 841..900 CDD:290566 13/58 (22%)
leucine-rich repeat 842..865 CDD:275380 5/22 (23%)
LRR_4 866..907 CDD:289563 8/40 (20%)
leucine-rich repeat 866..889 CDD:275380 2/22 (9%)
leucine-rich repeat 890..911 CDD:275380 5/20 (25%)
TIR 1045..1183 CDD:214587 43/156 (28%)
Tlr4NP_062051.2 PLN00113 23..>456 CDD:215061 127/515 (25%)
LRR 1 54..75 6/20 (30%)
leucine-rich repeat 58..78 CDD:275380 6/39 (15%)
LRR 2 78..99 9/20 (45%)
leucine-rich repeat 79..102 CDD:275380 10/24 (42%)
LRR 3 102..123 7/20 (35%)
leucine-rich repeat 103..126 CDD:275380 9/22 (41%)
LRR 4 126..147 6/41 (15%)
leucine-rich repeat 127..150 CDD:275380 8/43 (19%)
LRR 5 150..171 5/29 (17%)
leucine-rich repeat 151..175 CDD:275380 7/32 (22%)
LRR 6 175..198 8/25 (32%)
leucine-rich repeat 176..204 CDD:275380 9/30 (30%)
LRR 7 204..224 7/19 (37%)
leucine-rich repeat 205..226 CDD:275380 7/21 (33%)
LRR 8 226..247 10/30 (33%)
leucine-rich repeat 256..310 CDD:275380 15/71 (21%)
LRR 9 372..381 5/8 (63%)
leucine-rich repeat 373..398 CDD:275380 7/24 (29%)
LRR 10 398..420 7/21 (33%)
leucine-rich repeat 399..421 CDD:275380 7/21 (33%)
LRR 11 421..442 6/23 (26%)
leucine-rich repeat 422..446 CDD:275380 6/23 (26%)
LRR 12 446..467 5/33 (15%)
leucine-rich repeat 447..470 CDD:275380 6/35 (17%)
LRR 13 470..491 8/34 (24%)
leucine-rich repeat 471..495 CDD:275380 7/37 (19%)
LRR_8 494..554 CDD:404697 24/158 (15%)
LRR 14 495..516 10/101 (10%)
leucine-rich repeat 496..519 CDD:275380 12/121 (10%)
LRR 15 519..540 5/20 (25%)
leucine-rich repeat 520..543 CDD:275380 7/22 (32%)
LRR 16 543..564 6/37 (16%)
leucine-rich repeat 544..567 CDD:275380 7/46 (15%)
TIR 672..813 CDD:214587 42/154 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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