DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and Slitrk6

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001099527.1	Gene:	Slitrk6 / 290467	RGDID:	1306550	Length:	840	Species:	Rattus norvegicus

Alignment Length:	874	Identity:	197/874 - (22%)
Similarity:	303/874 - (34%)	Gaps:	227/874 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 TFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNL 416
            |.:|...:.|::.....|..:.:.:..|....| |:|..|.|.||....|:||.....:.|..|.
  Rat    36 TCEEKDGIMIINCEEKGINTLSQISVPPSRPFH-LSLLNNGLTTLHTNDFSGLTNALSIHLGFNN 99

  Fly   417 VSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGL 481
            ::.:|:.||..                       |.:||.|.:..|.:...|.:||..|..|..|
  Rat   100 IADIETGAFNG-----------------------LGLLKQLHINHNSLEILKEDTFHGLENLEFL 141

  Fly   482 RLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATL 546
            :..:|.|..|....|..|.||.||.|..|.|:|:....|
  Rat   142 QADNNFITVIEQSAFSKLNRLKVLILNDNAIESLPPNIF-------------------------- 180

  Fly   547 ASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEI-RVTTLDASHNRITEIG 610
                              .|:|  |..||:.||.::.| .|....|.| |:..|....|:..
  Rat   181 ------------------RFVP--LTHLDLRGNQLQTL-PYVGFLEHIGRILDLQLEDNKWA--- 221

  Fly   611 AMSVPNSIELLFINN--------NIIGQIQANTFVDKTRLARVDLYANVLSKIS-LNALRVAPVS 666
                 .:.|||.:.|        :|||.              |..|:..|.|.| |:.|:...:.
  Rat   222 -----CNCELLQLKNWLENMPPQSIIGD--------------VICYSPPLFKGSILSRLKKESIC 267

  Fly   667 AEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSAS 731
            ...||.|        |.:.....|..|.:.|:...           |...:.|...:|..:..:.
  Rat   268 PTPPVYE--------EHEDPAGSLLAITSSTSDSR-----------LSSKNTSILKQPTKAPGSV 313

  Fly   732 DFVCKYESHCP-PTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPN--RIPQD 793
            .::.|..:..| |.|..    .|.|:|:.|...           ::.|..:::.::.:  ..|.:
  Rat   314 PYLTKPSTQLPVPYCPV----PCNCKVLSPSGL-----------LIHCQERNIESVSDLQPPPHN 363

  Fly   794 VSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGT 858
            ...|.|.||.:..|....|.....|..|:|..:.:..|:.||...|..|:.|:|..|.||.|...
  Rat   364 PRKLILAGNIIHTLMKADLMDYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLYKG 428

  Fly   859 EFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLP------------------- 904
            .|..|..|..|||..|.:..|...||.|:..|:||.|:||.|..||
  Rat   429 MFLGLSSLEYLYLEYNAVKEILPGTFNPMPKLKVLYLNNNLLHVLPAHIFLGIPLTRVNLKTNQF 493

  Fly   905 -HLQYRHSLQGL------TLGRNAWSCRCQQLRELAQFVSD-NAMVVRDAHDIYCLDAG--IKRE 959
             ||...:.|..|      .|..|.|.|.| .|..|.|::.. ....|.|  ||.|...|  .|:|
  Rat   494 THLPVSNILDDLDLLIQIDLEDNPWDCSC-DLVGLQQWIHKLGKGTVTD--DILCASPGHLDKKE 555

  Fly   960 LELIGN------LANGPDC------------SDLLDASASNISSSQDLAGGYRLPLLAAVLVLIF 1006
            |:.:.:      |.|.|..            :...||:.:.:||   |.....|.:|...|:::|
  Rat   556 LKALNSELLCPGLVNNPSMPTQTSYIIVTSPTMAADAAGTLLSS---LTDAVPLSVLILGLLIVF 617

  Fly  1007 LVVVL----IIVFVFRESVRMWLFAHYGVRVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAEL 1067
            :.:|.    |:|||.....|      |..:..|.:..|...::....::..|.........::.|
  Rat   618 ITIVFCAAGIVVFVLHRRRR------YKKKKVEEQLRDTSPVHLQYSMYGHKTTHHTTERPSSSL 676

  Fly  1068 --EHGRPPFRLCIQQRDLPPQASHLQLV------EGARASRKIILVLTRNLLATEWNRIEFRNAF 1124
              :|...|.....:.....|:  ||:.|      ||..|..     |.|:||..|         .
  Rat   677 YEQHMVSPMVHVYRSPSFGPK--HLEEVEERSDKEGNDAKH-----LQRSLLERE---------N 725

  Fly  1125 HESLRGLAQKLVIIEETSVSAEAEDVAEL 1153
            |..|.|...|..::::::.....:|.:.|
  Rat   726 HSPLTGSNMKYKVVDQSTDFLPFQDASLL 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380
		LRR_RI	210..464	CDD:238064	25/111 (23%)
		leucine-rich repeat	212..236	CDD:275380
		LRR_8	235..295	CDD:290566
		leucine-rich repeat	237..260	CDD:275380
		leucine-rich repeat	261..284	CDD:275380
		LRR_8	283..345	CDD:290566
		leucine-rich repeat	285..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		LRR_8	334..393	CDD:290566	9/40 (23%)
		leucine-rich repeat	335..358	CDD:275380	2/5 (40%)
		leucine-rich repeat	359..382	CDD:275380	3/22 (14%)
		LRR_8	382..441	CDD:290566	15/58 (26%)
		leucine-rich repeat	383..406	CDD:275380	10/22 (45%)
		leucine-rich repeat	407..430	CDD:275380	5/22 (23%)
		LRR_8	431..488	CDD:290566	12/56 (21%)
		leucine-rich repeat	431..451	CDD:275380	0/19 (0%)
		leucine-rich repeat	454..477	CDD:275380	8/22 (36%)
		LRR_8	477..559	CDD:290566	16/81 (20%)
		leucine-rich repeat	478..499	CDD:275380	6/20 (30%)
		leucine-rich repeat	502..525	CDD:275380	8/22 (36%)
		leucine-rich repeat	526..548	CDD:275380	0/21 (0%)
		leucine-rich repeat	590..617	CDD:275380	5/27 (19%)
		leucine-rich repeat	618..641	CDD:275380	7/30 (23%)
		leucine-rich repeat	642..689	CDD:275380	11/47 (23%)
		LRRCT	679..736	CDD:214507	7/56 (13%)
		leucine-rich repeat	775..796	CDD:275380	2/22 (9%)
		LRR_8	797..852	CDD:290566	17/54 (31%)
		leucine-rich repeat	797..817	CDD:275380	6/19 (32%)
		leucine-rich repeat	818..841	CDD:275380	7/22 (32%)
		LRR_8	841..900	CDD:290566	24/58 (41%)
		leucine-rich repeat	842..865	CDD:275380	9/22 (41%)
		LRR_4	866..907	CDD:289563	19/60 (32%)
		leucine-rich repeat	866..889	CDD:275380	9/22 (41%)
		leucine-rich repeat	890..911	CDD:275380	11/40 (28%)
		TIR	1045..1183	CDD:214587	22/117 (19%)
Slitrk6	NP_001099527.1	leucine-rich repeat	68..89	CDD:275380	10/21 (48%)
		LRR_8	69..124	CDD:290566	19/77 (25%)
		leucine-rich repeat	94..113	CDD:275380	6/41 (15%)
		leucine-rich repeat	114..137	CDD:275380	8/22 (36%)
		LRR_8	137..195	CDD:290566	23/103 (22%)
		leucine-rich repeat	138..161	CDD:275380	7/22 (32%)
		leucine-rich repeat	162..177	CDD:275380	7/14 (50%)
		leucine-rich repeat	185..260	CDD:275380	25/97 (26%)
		leucine-rich repeat	210..222	CDD:275378	2/19 (11%)
		TPKR_C2	218..268	CDD:301599	15/71 (21%)
		leucine-rich repeat	261..411	CDD:275380	34/183 (19%)
		leucine-rich repeat	365..387	CDD:275380	6/21 (29%)
		LRR_8	387..444	CDD:290566	20/56 (36%)
		LRR_4	388..425	CDD:289563	13/36 (36%)
		LRR_4	410..449	CDD:289563	14/38 (37%)
		leucine-rich repeat	412..435	CDD:275380	9/22 (41%)
		LRR_8	434..493	CDD:290566	18/58 (31%)
		leucine-rich repeat	436..459	CDD:275380	9/22 (41%)
		leucine-rich repeat	460..481	CDD:275380	9/20 (45%)
		LRRCT	516..566	CDD:214507	16/52 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050