DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and Tlr13

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_991389.1	Gene:	Tlr13 / 279572	MGIID:	3045213	Length:	991	Species:	Mus musculus

Alignment Length:	1248	Identity:	278/1248 - (22%)
Similarity:	456/1248 - (36%)	Gaps:	400/1248 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 GLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELS 148
            ||:|.|.:|.:    :..::.||.|.......|.        ..|.| ||::::|.||
Mouse     3 GLYRILVQLEQ----SPYVKTVPLNMRRDFFFLV--------VTWMP-KTVKMNGSSF------- 47

  Fly   149 ELHLGDNNIRQLPEGVWCSMPSLQLLNLTQ-------------NRIRSAEFLGFSEKLCAGSALS 200
                               :||||||.:..             |:....|| .....||....::
Mouse    48 -------------------VPSLQLLLMLVGFSLPPVAETYGFNKCTQYEF-DIHHVLCIRKKIT 92

  Fly   201 NANGAVSGGSELQT-LDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVL 264
            |...|:|......| |:::.||::.|| .|..:.|..|..|.|:.|:|..:...|..||.:|.:|
Mouse    93 NLTEAISDIPRYTTHLNLTHNEIQVLP-PWSFTNLSALVDLRLEWNSIWKIDEGAFRGLENLTLL 156

  Fly   265 NISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTF 329
            |:..|.:.|: :.:|.|                        |..|..|.||.||:|  |:....|
Mouse   157 NLVENKIQSV-NNSFEG------------------------LSSLKTLLLSHNQIT--HIHKDAF 194

  Fly   330 AGLIRLIVLNLSNNALTRIGS--KTFKELYFLQILDMRNNSIGHIE--------------EG--- 375
            ..||:|..|:||.|.::....  :..:.|..|:.||:.||||.:::              ||
Mouse   195 TPLIKLKYLSLSRNNISDFSGILEAVQHLPCLERLDLTNNSIMYLDHSPRSLVSLTHLSFEGNKL 259

  Fly   376 -----AFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELD 435
                 :.|.|.||..|:.:.|....:.|.....|..|..|.|:..::.: |:.:.::..:|:.:|
Mouse   260 RELNFSALSLPNLTNLSASRNGNKVIQNVYLKTLPQLKSLNLSGTVIKL-ENLSAKHLQNLRAMD 323

  Fly   436 LSSNQLTE-------VPEAVQDLSMLKT------------------------LDLGENQISEFKN 469
            ||:.:|..       |...:.:|..|:|                        ||||:|....:.|
Mouse   324 LSNWELRHGHLDMKTVCHLLGNLPKLETLVFQKNVTNAEGIKQLAKCTRLLFLDLGQNSDLIYLN 388

  Fly   470 NT-FRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDK 533
            :: |..|..|..|.|...::..|....:..|..|:.|:|:.|:.:|....||.....:|.:.|.:
Mouse   389 DSEFNALPSLQKLNLNKCQLSFINNRTWSSLQNLTSLDLSHNKFKSFPDFAFSPLKHLEFLSLSR 453

  Fly   534 NFLTDINGI-FATLASLLWLNLSENHLVWFD-YAFIP-SNLKWLDIHGNYIEALGNYYKLQEEIR 595
            |.:|::|.: |:.|.:|..|||:...:|..| |:|.. .||:.||:..|.|..|.:
Mouse   454 NPITELNNLAFSGLFALKELNLAACWIVTIDRYSFTQFPNLEVLDLGDNNIRTLNH--------- 509

  Fly   596 VTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKI----- 655
                          |.......::.|.:::|.:..::.|:|...|.|..:||..|.||..
Mouse   510 --------------GTFRPLKKLQSLILSHNCLKILEPNSFSGLTNLRSLDLMYNSLSYFHEHLF 560

  Fly   656 -SLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTR--QHPHVVDLGNIECLMPHS 717
             .|..|.:           ..||.|            :|...|||  |:|..:.|.:::.|....
Mouse   561 SGLEKLLI-----------LKLGFN------------KITYETTRTLQYPPFIKLKSLKQLNLEG 602

  Fly   718 R--------SAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATN 774
            :        |...:.|.||.                          |::...|.|.|.|......
Mouse   603 QRHGIQVVPSNFFQGLGSLQ--------------------------ELLLGKNPSVFLDHHQFDP 641

  Fly   775 IVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQL 839
            :::..:.|::...            ||:                |:||||||   ..||     |
Mouse   642 LINLTKLDISGTK------------DGD----------------RSLYLNAS---LFQN-----L 670

  Fly   840 VNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLS-SL 903
            ..|::|.||||.|.:|....|.||..|:...|..|.|..|:.:..:.|.||....:..|:|. :.
Mouse   671 KRLKILRLENNNLESLVPDMFSSLQSLQVFSLRFNNLKVINQSHLKNLKSLMFFDVYGNKLQCTC 735

  Fly   904 PHLQYRHSLQGLTLGRNAWSCR-------------CQQLRELAQFVS-DNAMVVRDAHDIYCLDA 954
            .:|.:::           ||..             |||....:..:. |:||...|...:|.|
Mouse   736 DNLWFKN-----------WSMNTEEVHIPFLRSYPCQQPGSQSLLIDFDDAMCNFDLGKVYFL-- 787

  Fly   955 GIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRE 1019
                             ||                                |.:|:..:||.: .
Mouse   788 -----------------CS--------------------------------FSMVLSTMVFSW-F 802

  Fly  1020 SVRMWLFAHYGVRVC-----------EPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHG-RP 1072
            |.:|.....||:.:|           |.:|     ||||.:..|..|..:|.:.:...||.| :.
Mouse   803 STKMIASLWYGLYICRAWYLTKWHKTEKKF-----LYDAFVSFSATDEAWVYKELVPALEQGSQT 862

  Fly  1073 PFRLCIQQRDLPPQASHLQLVEGA-RASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLV 1136
            .|:||:.|||..|.....:.::.| ..|||.:.|::.:.|.:||.|:|                |
Mouse   863 TFKLCLHQRDFEPGIDIFENIQNAINTSRKTLCVVSNHYLHSEWCRLE----------------V 911

  Fly  1137 IIEETSVSAEAEDVAELSPYLKSVPSNRLLTCDR---------------------YFWEKLRYAI 1180
            .:....:..|.:||..|. :|:.:|:.:|.:..|                     .||.::|.|:
Mouse   912 QLASMKMFYEHKDVIILI-FLEEIPNYKLSSYHRLRKLINKQTFITWPDSVHQQPLFWARIRNAL 975

  Fly  1181 PIELSPRGNNYTL 1193
            ..|...:.|.:.:
Mouse   976 GKETVEKENTHLI 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380	4/6 (67%)
		leucine-rich repeat	92..115	CDD:275380	4/22 (18%)
		LRR_8	115..181	CDD:290566	15/78 (19%)
		leucine-rich repeat	116..146	CDD:275380	8/29 (28%)
		leucine-rich repeat	147..170	CDD:275380	0/22 (0%)
		leucine-rich repeat	171..201	CDD:275380	9/42 (21%)
		LRR_RI	210..464	CDD:238064	76/309 (25%)
		leucine-rich repeat	212..236	CDD:275380	8/24 (33%)
		LRR_8	235..295	CDD:290566	15/59 (25%)
		leucine-rich repeat	237..260	CDD:275380	8/22 (36%)
		leucine-rich repeat	261..284	CDD:275380	7/22 (32%)
		LRR_8	283..345	CDD:290566	17/61 (28%)
		leucine-rich repeat	285..308	CDD:275380	1/22 (5%)
		leucine-rich repeat	309..334	CDD:275380	10/24 (42%)
		LRR_8	334..393	CDD:290566	21/82 (26%)
		leucine-rich repeat	335..358	CDD:275380	6/24 (25%)
		leucine-rich repeat	359..382	CDD:275380	11/44 (25%)
		LRR_8	382..441	CDD:290566	14/58 (24%)
		leucine-rich repeat	383..406	CDD:275380	5/22 (23%)
		leucine-rich repeat	407..430	CDD:275380	4/22 (18%)
		LRR_8	431..488	CDD:290566	20/88 (23%)
		leucine-rich repeat	431..451	CDD:275380	6/26 (23%)
		leucine-rich repeat	454..477	CDD:275380	10/47 (21%)
		LRR_8	477..559	CDD:290566	23/82 (28%)
		leucine-rich repeat	478..499	CDD:275380	4/20 (20%)
		leucine-rich repeat	502..525	CDD:275380	7/22 (32%)
		leucine-rich repeat	526..548	CDD:275380	7/22 (32%)
		leucine-rich repeat	590..617	CDD:275380	1/26 (4%)
		leucine-rich repeat	618..641	CDD:275380	4/22 (18%)
		leucine-rich repeat	642..689	CDD:275380	11/52 (21%)
		LRRCT	679..736	CDD:214507	13/66 (20%)
		leucine-rich repeat	775..796	CDD:275380	1/20 (5%)
		LRR_8	797..852	CDD:290566	18/54 (33%)
		leucine-rich repeat	797..817	CDD:275380	2/19 (11%)
		leucine-rich repeat	818..841	CDD:275380	10/22 (45%)
		LRR_8	841..900	CDD:290566	20/58 (34%)
		leucine-rich repeat	842..865	CDD:275380	11/22 (50%)
		LRR_4	866..907	CDD:289563	10/41 (24%)
		leucine-rich repeat	866..889	CDD:275380	6/22 (27%)
		leucine-rich repeat	890..911	CDD:275380	4/21 (19%)
		TIR	1045..1183	CDD:214587	39/160 (24%)
Tlr13	NP_991389.1	LRR 1	104..125		7/21 (33%)
		leucine-rich repeat	105..128	CDD:275380	8/23 (35%)
		LRR_8	106..163	CDD:290566	20/57 (35%)
		LRR 2	128..149		6/20 (30%)
		leucine-rich repeat	129..152	CDD:275380	8/22 (36%)
		LRR 3	152..174		7/46 (15%)
		leucine-rich repeat	153..175	CDD:275380	8/46 (17%)
		LRR 4	175..196		9/22 (41%)
		leucine-rich repeat	176..199	CDD:275380	10/24 (42%)
		LRR_8	183..236	CDD:290566	18/54 (33%)
		LRR_RI	<192..405	CDD:238064	50/213 (23%)
		LRR 5	199..220		5/20 (25%)
		leucine-rich repeat	200..225	CDD:275380	6/24 (25%)
		LRR 6	225..246		7/20 (35%)
		leucine-rich repeat	226..248	CDD:275380	7/21 (33%)
		LRR 7	248..268		2/19 (11%)
		leucine-rich repeat	249..271	CDD:275380	4/21 (19%)
		LRR 8	271..292		5/20 (25%)
		leucine-rich repeat	272..295	CDD:275380	5/22 (23%)
		LRR 9	295..315		4/20 (20%)
		leucine-rich repeat	296..319	CDD:275380	4/23 (17%)
		LRR 10	318..338		5/19 (26%)
		LRR 11	348..368		2/19 (11%)
		LRR 12	372..394		7/21 (33%)
		leucine-rich repeat	373..397	CDD:275380	8/23 (35%)
		LRR_8	396..456	CDD:290566	15/59 (25%)
		LRR 13	397..418		4/20 (20%)
		leucine-rich repeat	398..421	CDD:275380	5/22 (23%)
		LRR_4	420..463	CDD:289563	12/42 (29%)
		LRR 14	421..442		7/20 (35%)
		leucine-rich repeat	422..445	CDD:275380	7/22 (32%)
		LRR 15	445..466		6/20 (30%)
		leucine-rich repeat	446..469	CDD:275380	7/22 (32%)
		LRR 16	469..490		8/20 (40%)
		leucine-rich repeat	470..493	CDD:275380	8/22 (36%)
		LRR_8	492..552	CDD:290566	17/82 (21%)
		LRR 17	493..514		8/43 (19%)
		leucine-rich repeat	494..517	CDD:275380	7/45 (16%)
		LRR 18	517..538		4/20 (20%)
		leucine-rich repeat	518..541	CDD:275380	4/22 (18%)
		LRR_8	540..602	CDD:290566	20/84 (24%)
		LRR 19	541..562		6/20 (30%)
		leucine-rich repeat	542..565	CDD:275380	7/22 (32%)
		LRR 20	565..585		8/42 (19%)
		leucine-rich repeat	566..585	CDD:275380	8/41 (20%)
		LRR 21	594..617		2/22 (9%)
		LRR 22	620..641		7/46 (15%)
		LRR 23	644..665		8/48 (17%)
		LRR_8	671..731	CDD:290566	20/59 (34%)
		LRR 24	672..693		9/20 (45%)
		leucine-rich repeat	673..696	CDD:275380	11/22 (50%)
		LRR 25	696..716		5/19 (26%)
		leucine-rich repeat	697..718	CDD:275380	5/20 (25%)
		TIR	834..976	CDD:214587	39/158 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4007
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.830