DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Tlr13

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_991389.1 Gene:Tlr13 / 279572 MGIID:3045213 Length:991 Species:Mus musculus


Alignment Length:1248 Identity:278/1248 - (22%)
Similarity:456/1248 - (36%) Gaps:400/1248 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 GLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELS 148
            ||:|.|.:|.:    :..::.||.|.......|.        ..|.| ||::::|.||       
Mouse     3 GLYRILVQLEQ----SPYVKTVPLNMRRDFFFLV--------VTWMP-KTVKMNGSSF------- 47

  Fly   149 ELHLGDNNIRQLPEGVWCSMPSLQLLNLTQ-------------NRIRSAEFLGFSEKLCAGSALS 200
                               :||||||.:..             |:....|| .....||....::
Mouse    48 -------------------VPSLQLLLMLVGFSLPPVAETYGFNKCTQYEF-DIHHVLCIRKKIT 92

  Fly   201 NANGAVSGGSELQT-LDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVL 264
            |...|:|......| |:::.||::.|| .|..:.|..|..|.|:.|:|..:...|..||.:|.:|
Mouse    93 NLTEAISDIPRYTTHLNLTHNEIQVLP-PWSFTNLSALVDLRLEWNSIWKIDEGAFRGLENLTLL 156

  Fly   265 NISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTF 329
            |:..|.:.|: :.:|.|                        |..|..|.||.||:|  |:....|
Mouse   157 NLVENKIQSV-NNSFEG------------------------LSSLKTLLLSHNQIT--HIHKDAF 194

  Fly   330 AGLIRLIVLNLSNNALTRIGS--KTFKELYFLQILDMRNNSIGHIE--------------EG--- 375
            ..||:|..|:||.|.::....  :..:.|..|:.||:.||||.:::              ||   
Mouse   195 TPLIKLKYLSLSRNNISDFSGILEAVQHLPCLERLDLTNNSIMYLDHSPRSLVSLTHLSFEGNKL 259

  Fly   376 -----AFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELD 435
                 :.|.|.||..|:.:.|....:.|.....|..|..|.|:..::.: |:.:.::..:|:.:|
Mouse   260 RELNFSALSLPNLTNLSASRNGNKVIQNVYLKTLPQLKSLNLSGTVIKL-ENLSAKHLQNLRAMD 323

  Fly   436 LSSNQLTE-------VPEAVQDLSMLKT------------------------LDLGENQISEFKN 469
            ||:.:|..       |...:.:|..|:|                        ||||:|....:.|
Mouse   324 LSNWELRHGHLDMKTVCHLLGNLPKLETLVFQKNVTNAEGIKQLAKCTRLLFLDLGQNSDLIYLN 388

  Fly   470 NT-FRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDK 533
            :: |..|..|..|.|...::..|....:..|..|:.|:|:.|:.:|....||.....:|.:.|.:
Mouse   389 DSEFNALPSLQKLNLNKCQLSFINNRTWSSLQNLTSLDLSHNKFKSFPDFAFSPLKHLEFLSLSR 453

  Fly   534 NFLTDINGI-FATLASLLWLNLSENHLVWFD-YAFIP-SNLKWLDIHGNYIEALGNYYKLQEEIR 595
            |.:|::|.: |:.|.:|..|||:...:|..| |:|.. .||:.||:..|.|..|.:         
Mouse   454 NPITELNNLAFSGLFALKELNLAACWIVTIDRYSFTQFPNLEVLDLGDNNIRTLNH--------- 509

  Fly   596 VTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKI----- 655
                          |.......::.|.:::|.:..::.|:|...|.|..:||..|.||..     
Mouse   510 --------------GTFRPLKKLQSLILSHNCLKILEPNSFSGLTNLRSLDLMYNSLSYFHEHLF 560

  Fly   656 -SLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTR--QHPHVVDLGNIECLMPHS 717
             .|..|.:           ..||.|            :|...|||  |:|..:.|.:::.|....
Mouse   561 SGLEKLLI-----------LKLGFN------------KITYETTRTLQYPPFIKLKSLKQLNLEG 602

  Fly   718 R--------SAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATN 774
            :        |...:.|.||.                          |::...|.|.|.|......
Mouse   603 QRHGIQVVPSNFFQGLGSLQ--------------------------ELLLGKNPSVFLDHHQFDP 641

  Fly   775 IVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQL 839
            :::..:.|::...            ||:                |:||||||   ..||     |
Mouse   642 LINLTKLDISGTK------------DGD----------------RSLYLNAS---LFQN-----L 670

  Fly   840 VNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLS-SL 903
            ..|::|.||||.|.:|....|.||..|:...|..|.|..|:.:..:.|.||....:..|:|. :.
Mouse   671 KRLKILRLENNNLESLVPDMFSSLQSLQVFSLRFNNLKVINQSHLKNLKSLMFFDVYGNKLQCTC 735

  Fly   904 PHLQYRHSLQGLTLGRNAWSCR-------------CQQLRELAQFVS-DNAMVVRDAHDIYCLDA 954
            .:|.:::           ||..             |||....:..:. |:||...|...:|.|  
Mouse   736 DNLWFKN-----------WSMNTEEVHIPFLRSYPCQQPGSQSLLIDFDDAMCNFDLGKVYFL-- 787

  Fly   955 GIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRE 1019
                             ||                                |.:|:..:||.: .
Mouse   788 -----------------CS--------------------------------FSMVLSTMVFSW-F 802

  Fly  1020 SVRMWLFAHYGVRVC-----------EPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHG-RP 1072
            |.:|.....||:.:|           |.:|     ||||.:..|..|..:|.:.:...||.| :.
Mouse   803 STKMIASLWYGLYICRAWYLTKWHKTEKKF-----LYDAFVSFSATDEAWVYKELVPALEQGSQT 862

  Fly  1073 PFRLCIQQRDLPPQASHLQLVEGA-RASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLV 1136
            .|:||:.|||..|.....:.::.| ..|||.:.|::.:.|.:||.|:|                |
Mouse   863 TFKLCLHQRDFEPGIDIFENIQNAINTSRKTLCVVSNHYLHSEWCRLE----------------V 911

  Fly  1137 IIEETSVSAEAEDVAELSPYLKSVPSNRLLTCDR---------------------YFWEKLRYAI 1180
            .:....:..|.:||..|. :|:.:|:.:|.:..|                     .||.::|.|:
Mouse   912 QLASMKMFYEHKDVIILI-FLEEIPNYKLSSYHRLRKLINKQTFITWPDSVHQQPLFWARIRNAL 975

  Fly  1181 PIELSPRGNNYTL 1193
            ..|...:.|.:.:
Mouse   976 GKETVEKENTHLI 988

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 4/6 (67%)
leucine-rich repeat 92..115 CDD:275380 4/22 (18%)
LRR_8 115..181 CDD:404697 15/78 (19%)
leucine-rich repeat 116..146 CDD:275380 8/29 (28%)
leucine-rich repeat 147..170 CDD:275380 0/22 (0%)
leucine-rich repeat 171..201 CDD:275380 9/42 (21%)
LRR 210..592 CDD:443914 113/441 (26%)
leucine-rich repeat 212..236 CDD:275380 8/24 (33%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 7/22 (32%)
leucine-rich repeat 285..308 CDD:275380 1/22 (5%)
leucine-rich repeat 309..334 CDD:275380 10/24 (42%)
leucine-rich repeat 335..358 CDD:275380 6/24 (25%)
leucine-rich repeat 359..382 CDD:275380 11/44 (25%)
leucine-rich repeat 383..406 CDD:275380 5/22 (23%)
leucine-rich repeat 407..430 CDD:275380 4/22 (18%)
leucine-rich repeat 431..451 CDD:275380 6/26 (23%)
leucine-rich repeat 454..477 CDD:275380 10/47 (21%)
leucine-rich repeat 478..499 CDD:275380 4/20 (20%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 7/22 (32%)
leucine-rich repeat 590..617 CDD:275380 1/26 (4%)
leucine-rich repeat 618..641 CDD:275380 4/22 (18%)
leucine-rich repeat 642..689 CDD:275380 11/52 (21%)
LRRCT 679..736 CDD:214507 13/66 (20%)
LRR <775..>920 CDD:443914 35/145 (24%)
leucine-rich repeat 775..796 CDD:275380 1/20 (5%)
leucine-rich repeat 797..817 CDD:275380 2/19 (11%)
leucine-rich repeat 818..841 CDD:275380 10/22 (45%)
leucine-rich repeat 842..865 CDD:275380 11/22 (50%)
leucine-rich repeat 866..889 CDD:275380 6/22 (27%)
leucine-rich repeat 890..911 CDD:275380 4/21 (19%)
TIR 1045..1183 CDD:214587 39/160 (24%)
Tlr13NP_991389.1 LRR 84..479 CDD:443914 107/423 (25%)
LRR 1 104..125 7/21 (33%)
leucine-rich repeat 105..128 CDD:275380 8/23 (35%)
LRR 2 128..149 6/20 (30%)
leucine-rich repeat 129..152 CDD:275380 8/22 (36%)
LRR 3 152..174 7/46 (15%)
leucine-rich repeat 153..175 CDD:275380 8/46 (17%)
LRR 4 175..196 9/22 (41%)
leucine-rich repeat 176..199 CDD:275380 10/24 (42%)
LRR 5 199..220 5/20 (25%)
leucine-rich repeat 200..225 CDD:275380 6/24 (25%)
LRR 6 225..246 7/20 (35%)
leucine-rich repeat 226..248 CDD:275380 7/21 (33%)
LRR 7 248..268 2/19 (11%)
leucine-rich repeat 249..271 CDD:275380 4/21 (19%)
LRR 8 271..292 5/20 (25%)
leucine-rich repeat 272..295 CDD:275380 5/22 (23%)
LRR 9 295..315 4/20 (20%)
leucine-rich repeat 296..319 CDD:275380 4/23 (17%)
LRR 10 318..338 5/19 (26%)
LRR 342..707 CDD:443914 106/472 (22%)
LRR 11 348..368 2/19 (11%)
LRR 12 372..394 7/21 (33%)
leucine-rich repeat 373..397 CDD:275380 8/23 (35%)
LRR 13 397..418 4/20 (20%)
leucine-rich repeat 398..421 CDD:275380 5/22 (23%)
LRR 14 421..442 7/20 (35%)
leucine-rich repeat 422..445 CDD:275380 7/22 (32%)
LRR 15 445..466 6/20 (30%)
leucine-rich repeat 446..469 CDD:275380 7/22 (32%)
LRR 16 469..490 8/20 (40%)
leucine-rich repeat 470..493 CDD:275380 8/22 (36%)
LRR 17 493..514 8/43 (19%)
leucine-rich repeat 494..517 CDD:275380 7/45 (16%)
LRR 18 517..538 4/20 (20%)
leucine-rich repeat 518..541 CDD:275380 4/22 (18%)
LRR 19 541..562 6/20 (30%)
leucine-rich repeat 542..565 CDD:275380 7/22 (32%)
LRR 20 565..585 8/42 (19%)
leucine-rich repeat 566..585 CDD:275380 8/41 (20%)
LRR 21 594..617 2/22 (9%)
LRR 22 620..641 7/46 (15%)
LRR 23 644..665 8/48 (17%)
LRR 24 672..693 9/20 (45%)
leucine-rich repeat 673..696 CDD:275380 11/22 (50%)
LRR 25 696..716 5/19 (26%)
leucine-rich repeat 697..718 CDD:275380 5/20 (25%)
TIR 834..976 CDD:214587 39/158 (25%)

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