DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and LRRTM2

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_056379.1 Gene:LRRTM2 / 26045 HGNCID:19409 Length:516 Species:Homo sapiens


Alignment Length:588 Identity:140/588 - (23%)
Similarity:216/588 - (36%) Gaps:175/588 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   224 SLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELREL 288
            |:|:|.....|    .|||:||:|:.|..:..|..|.|..|::.:|.:.::..:||.|..:|:||
Human    54 SVPNATDKGSL----GLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKEL 114

  Fly   289 HLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTF 353
            .|..|.::.||.....:|..|..||||.|||:|.|.:  .|.||.:|..|:|.:|:|..|..:.|
Human   115 ILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPE--LFYGLRKLQTLHLRSNSLRTIPVRLF 177

  Fly   354 KELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVS 418
            .:...|:.||                        |:.|||.:|....|.||.             
Human   178 WDCRSLEFLD------------------------LSTNRLRSLARNGFAGLI------------- 205

  Fly   419 IVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRL 483
                       .|:||.|..||||::..|                       .|..|:.|..|.|
Human   206 -----------KLRELHLEHNQLTKINFA-----------------------HFLRLSSLHTLFL 236

  Fly   484 IDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDING-IFATLA 547
            ..|:|.|:|.||......|..|:|..|.|::|:...|:....::.:.:|.|.|..::. |..:|.
Human   237 QWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLR 301

  Fly   548 SLLWLNLSENHLVWFDYAFIPSNLKWL-DIHGNYIEAL---GNYYKLQEEIRVTTLDASHNRITE 608
            ||..:.||.|  :|...|.|.:...|| ...|.:..::   ...:...|:|    |||.|     
Human   302 SLTTVGLSGN--LWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDI----LDAVH----- 355

  Fly   609 IGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVA---------- 663
                    ..:|.: |.:....:.|.|:.|.|        .....:||.::..|.          
Human   356 --------GFQLCW-NLSTTVTVMATTYRDPT--------TEYTKRISSSSYHVGDKEIPTTAGI 403

  Fly   664 PVSAEKPVPE---------------------FYLGGNPF---EC---------DCSMEWLQRINN 695
            .|:.|:..||                     |::....|   :|         .|||....|...
Human   404 AVTTEEHFPEPDNAIFTQRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLR 468

  Fly   696 LTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICP 760
            ..||.|     :.|:....|::...|                 :|..|......|.||:|:.:..
Human   469 SQTRLH-----MSNMSDQGPYNEYEP-----------------THEGPFIIINGYGQCKCQQLPY 511

  Fly   761 GNC 763
            ..|
Human   512 KEC 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR_RI 210..464 CDD:238064 67/239 (28%)
leucine-rich repeat 212..236 CDD:275380 4/11 (36%)
LRR_8 235..295 CDD:290566 20/59 (34%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 6/22 (27%)
LRR_8 283..345 CDD:290566 25/61 (41%)
leucine-rich repeat 285..308 CDD:275380 8/22 (36%)
leucine-rich repeat 309..334 CDD:275380 13/24 (54%)
LRR_8 334..393 CDD:290566 12/58 (21%)
leucine-rich repeat 335..358 CDD:275380 7/22 (32%)
leucine-rich repeat 359..382 CDD:275380 3/22 (14%)
LRR_8 382..441 CDD:290566 13/58 (22%)
leucine-rich repeat 383..406 CDD:275380 8/22 (36%)
leucine-rich repeat 407..430 CDD:275380 0/22 (0%)
LRR_8 431..488 CDD:290566 15/56 (27%)
leucine-rich repeat 431..451 CDD:275380 9/19 (47%)
leucine-rich repeat 454..477 CDD:275380 2/22 (9%)
LRR_8 477..559 CDD:290566 26/82 (32%)
leucine-rich repeat 478..499 CDD:275380 9/20 (45%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 5/22 (23%)
leucine-rich repeat 590..617 CDD:275380 6/26 (23%)
leucine-rich repeat 618..641 CDD:275380 5/22 (23%)
leucine-rich repeat 642..689 CDD:275380 13/89 (15%)
LRRCT 679..736 CDD:214507 12/68 (18%)
leucine-rich repeat 775..796 CDD:275380
LRR_8 797..852 CDD:290566
leucine-rich repeat 797..817 CDD:275380
leucine-rich repeat 818..841 CDD:275380
LRR_8 841..900 CDD:290566
leucine-rich repeat 842..865 CDD:275380
LRR_4 866..907 CDD:289563
leucine-rich repeat 866..889 CDD:275380
leucine-rich repeat 890..911 CDD:275380
TIR 1045..1183 CDD:214587
LRRTM2NP_056379.1 LRR 1 63..83 8/23 (35%)
LRR <65..312 CDD:227223 91/321 (28%)
leucine-rich repeat 66..86 CDD:275380 8/19 (42%)
LRR 2 86..107 5/20 (25%)
leucine-rich repeat 87..110 CDD:275380 6/22 (27%)
LRR 3 110..131 7/20 (35%)
leucine-rich repeat 111..134 CDD:275380 8/22 (36%)
LRR 4 134..155 11/22 (50%)
leucine-rich repeat 135..158 CDD:275380 13/24 (54%)
LRR 5 158..179 7/20 (35%)
leucine-rich repeat 159..182 CDD:275380 7/22 (32%)
LRR 6 182..203 9/44 (20%)
leucine-rich repeat 183..206 CDD:275380 11/70 (16%)
LRR 7 206..227 10/43 (23%)
leucine-rich repeat 207..230 CDD:275380 11/45 (24%)
LRR 8 230..251 9/20 (45%)
leucine-rich repeat 231..254 CDD:275380 9/22 (41%)
LRR 9 254..275 7/20 (35%)
leucine-rich repeat 255..278 CDD:275380 7/22 (32%)
LRR 10 278..299 4/20 (20%)
leucine-rich repeat 279..300 CDD:275380 4/20 (20%)
PCC 284..>351 CDD:188093 18/72 (25%)
Involved in DLG4-binding. /evidence=ECO:0000250 513..516 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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