DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Podnl1

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001013402.2 Gene:Podnl1 / 244550 MGIID:2685352 Length:559 Species:Mus musculus


Alignment Length:740 Identity:178/740 - (24%)
Similarity:260/740 - (35%) Gaps:279/740 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LLLLVAD---AHAQ---------------QQCNWQYGLTTMDIRCSVRALESGTGTPLDLQ---- 59
            ||||:..   ||.:               :.|.|         |||....::.....|||:    
Mouse     8 LLLLMLKWSLAHTEDPAFPHLGDSSQPLPRPCPW---------RCSCPRDDTVDCAGLDLRIFPD 63

  Fly    60 -VAEAAGRLDLQCSQELLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLES 123
             :..||..|.||.:|                            |:.:|.|....|..|:.|.|.|
Mouse    64 NITRAARHLSLQNNQ----------------------------LRELPYNELSRLSGLRTLDLHS 100

  Fly   124 HNAVWGPGKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMP-SLQLLNLTQNRIRSAEFL 187
             |.:...|    |..::|:.|.:|...::..|.:...|:    .:| ||::.:|..|.:.....|
Mouse   101 -NLITSEG----LPDEAFESLNQLENFYVAHNKLSVAPQ----FLPRSLRVADLAANEVVEIFPL 156

  Fly   188 GFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSL---PDAWGASRLRRLQTLSLQHNNIST 249
            .|.||                 ..|:::.:..|.||:.   |:.:..|.:  :.||||..|.:|.
Mouse   157 TFGEK-----------------PALRSVYLHNNRLRNTGLPPNTFHGSEV--ITTLSLSSNQLSY 202

  Fly   250 LAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDL 314
            |.|                    |||:       .|..||||.|.:.::|:|.|.....|..|.|
Mouse   203 LPP--------------------SLPA-------SLERLHLQNNLISKVPRGALSLQTHLRELYL 240

  Fly   315 SGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRI-----GSKTFKELYFLQILDMRNNSIGHIE- 373
            ..||||...:|.:||:.|..|..|:||:|.|..:     |:        |.||.:..|.|.|:| 
Mouse   241 QHNQLTDSGLDATTFSKLSSLEYLDLSHNQLATVPEGLPGT--------LTILHLGRNCIRHVEA 297

  Fly   374 -------------------------EGAFLPLYNLHTLNLAENRLH------------------- 394
                                     :|...||..||||:|..|:|.                   
Mouse   298 VRLHKARGLRYLLLQHNKLGASALPKGTLRPLRALHTLHLYGNKLERVPPALPRHLQALVMPHNH 362

  Fly   395 --TLDNRIFNGLYVLTKLTL-NNNLVSI-VESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLK 455
              .|..|.......|.:|.| .|:|.|. |...|||....|:.|||:.||||.:||.:.  :.|:
Mouse   363 VAALGARDLVSARALAELNLAYNSLASAHVHPSAFRRLRALRSLDLAGNQLTRLPEGLP--ASLR 425

  Fly   456 TLDLGENQISEFKNNTFRNLNQLTGLRLIDN--RIGNITVGMFQDLPRLSVLNLAKNRIQSIERG 518
            :|.|..||:...:......||:|..|.|..|  |:|:|..|.:.:|..|.||:|:.|.:      
Mouse   426 SLRLQRNQLRTLEPEQLAGLNKLRELNLAHNRLRVGDIGPGTWHELQALKVLDLSHNEL------ 484

  Fly   519 AFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEA 583
                                                          :|:|.:|.         ||
Mouse   485 ----------------------------------------------SFVPPDLP---------EA 494

  Fly   584 LGNYYKLQEEIRVTTLDASHNRITEIGA---MSVPNSIELLFINNNIIGQIQANTFVDKTRLARV 645
            |...|          |.|  |||:.:|.   :|.|: :..||:..|              ||...
Mouse   495 LEELY----------LQA--NRISHVGPEAFLSTPH-LRALFLRAN--------------RLHMT 532

  Fly   646 DLYANVLSKISLNALRVAPVSAEKP 670
            .:.|..|.  .|..|||.. :||.|
Mouse   533 SIRAEALQ--GLTHLRVVD-TAENP 554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 4/24 (17%)
leucine-rich repeat 92..115 CDD:275380 4/22 (18%)
LRR_8 115..181 CDD:404697 17/66 (26%)
leucine-rich repeat 116..146 CDD:275380 9/29 (31%)
leucine-rich repeat 147..170 CDD:275380 4/23 (17%)
leucine-rich repeat 171..201 CDD:275380 7/29 (24%)
LRR 210..592 CDD:443914 111/440 (25%)
leucine-rich repeat 212..236 CDD:275380 6/26 (23%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 3/22 (14%)
leucine-rich repeat 285..308 CDD:275380 9/22 (41%)
leucine-rich repeat 309..334 CDD:275380 11/24 (46%)
leucine-rich repeat 335..358 CDD:275380 7/27 (26%)
leucine-rich repeat 359..382 CDD:275380 10/48 (21%)
leucine-rich repeat 383..406 CDD:275380 9/43 (21%)
leucine-rich repeat 407..430 CDD:275380 10/24 (42%)
leucine-rich repeat 431..451 CDD:275380 10/19 (53%)
leucine-rich repeat 454..477 CDD:275380 6/22 (27%)
leucine-rich repeat 478..499 CDD:275380 8/22 (36%)
leucine-rich repeat 502..525 CDD:275380 5/22 (23%)
leucine-rich repeat 526..548 CDD:275380 0/21 (0%)
leucine-rich repeat 590..617 CDD:275380 8/29 (28%)
leucine-rich repeat 618..641 CDD:275380 3/22 (14%)
leucine-rich repeat 642..689 CDD:275380 10/29 (34%)
LRRCT 679..736 CDD:214507
LRR <775..>920 CDD:443914
leucine-rich repeat 775..796 CDD:275380
leucine-rich repeat 797..817 CDD:275380
leucine-rich repeat 818..841 CDD:275380
leucine-rich repeat 842..865 CDD:275380
leucine-rich repeat 866..889 CDD:275380
leucine-rich repeat 890..911 CDD:275380
TIR 1045..1183 CDD:214587
Podnl1NP_001013402.2 leucine-rich repeat 50..68 CDD:275380 3/17 (18%)
LRR 1. /evidence=ECO:0000255 66..89 9/50 (18%)
leucine-rich repeat 69..92 CDD:275380 9/50 (18%)
PLN00113 72..>507 CDD:215061 145/600 (24%)
LRR 2. /evidence=ECO:0000255 90..115 9/29 (31%)
leucine-rich repeat 93..118 CDD:275380 9/29 (31%)
LRR 3. /evidence=ECO:0000255 117..139 4/25 (16%)
leucine-rich repeat 119..163 CDD:275380 12/64 (19%)
LRR 4. /evidence=ECO:0000255 140..160 5/19 (26%)
LRR 5. /evidence=ECO:0000255 161..186 6/41 (15%)
leucine-rich repeat 164..189 CDD:275380 6/24 (25%)
LRR 6. /evidence=ECO:0000255 188..208 9/41 (22%)
leucine-rich repeat 190..210 CDD:275380 11/46 (24%)
LRR 7. /evidence=ECO:0000255 209..231 9/28 (32%)
leucine-rich repeat 211..234 CDD:275380 9/22 (41%)
LRR 8. /evidence=ECO:0000255 233..257 10/23 (43%)
leucine-rich repeat 235..260 CDD:275380 11/24 (46%)
LRR 9. /evidence=ECO:0000255 258..281 7/22 (32%)
leucine-rich repeat 261..305 CDD:275380 14/51 (27%)
LRR 10. /evidence=ECO:0000255 283..302 6/18 (33%)
LRR 11. /evidence=ECO:0000255 303..328 1/24 (4%)
leucine-rich repeat 306..331 CDD:275380 3/24 (13%)
LRR 12. /evidence=ECO:0000255 329..352 8/22 (36%)
leucine-rich repeat 332..402 CDD:275380 19/69 (28%)
LRR 13. /evidence=ECO:0000255 354..373 2/18 (11%)
LRR 14. /evidence=ECO:0000255 374..399 9/24 (38%)
LRR 15. /evidence=ECO:0000255 400..423 10/24 (42%)
leucine-rich repeat 403..423 CDD:275380 10/21 (48%)
leucine-rich repeat 424..447 CDD:275380 6/22 (27%)
LRR 16. /evidence=ECO:0000255 425..444 4/18 (22%)
LRR 17. /evidence=ECO:0000255 445..470 10/24 (42%)
leucine-rich repeat 448..473 CDD:275380 9/24 (38%)
LRR 18. /evidence=ECO:0000255 471..494 9/83 (11%)
leucine-rich repeat 474..494 CDD:275380 8/80 (10%)
LRR_8 495..549 CDD:404697 21/82 (26%)
leucine-rich repeat 495..513 CDD:275380 8/29 (28%)
LRR 19. /evidence=ECO:0000255 496..515 7/30 (23%)
LRR 20. /evidence=ECO:0000255 517..541 8/40 (20%)
leucine-rich repeat 519..544 CDD:275380 8/40 (20%)
Blue background indicates that the domain is not in the aligned region.

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