DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Tlr2

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:XP_006501523.1 Gene:Tlr2 / 24088 MGIID:1346060 Length:794 Species:Mus musculus


Alignment Length:888 Identity:212/888 - (23%)
Similarity:347/888 - (39%) Gaps:225/888 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   359 LQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQ 423
            ::.||:..|.|.:|..|......||..|.|..:|::|::...|..|..|..|.|::|.:|.:.|.
Mouse    64 MKSLDLSFNKITYIGHGDLRACANLQVLMLKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSS 128

  Fly   424 AFRNCSDLKELDLSSN--QLTEVPEAVQDLSMLKTLDLGE-NQISEFKNNTFRNLNQLTGLRLID 485
            .|...|.||.|:|..|  |...|.....:|:.|:||.:|. ...||.:...|..|..|..|    
Mouse   129 WFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSEIRRIDFAGLTSLNEL---- 189

  Fly   486 NRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRL---DKNFLTDINGIFA-TL 546
                        ::..||:.|.....::||.        :|..:.|   :..||.:   ||| .|
Mouse   190 ------------EIKALSLRNYQSQSLKSIR--------DIHHLTLHLSESAFLLE---IFADIL 231

  Fly   547 ASLLWLNLSENHLVWFDYAFIP-----SNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRI 606
            :|:.:|.|.:.:|..|.::.:|     |.:|.|...|:.:                 .|.|.|  
Mouse   232 SSVRYLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVL-----------------TDESFN-- 277

  Fly   607 TEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDL---YANVLSKISLNALRVAPVSAE 668
                        |||.:...|: ::....|.|.|.....|.   .::|:|::.    :|..|:..
Mouse   278 ------------ELLKLLRYIL-ELSEVEFDDCTLNGLGDFNPSESDVVSELG----KVETVTIR 325

  Fly   669 K-PVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASD 732
            : .:|:|||.   ::.......|:::..:|       |:...: .|:|.|.|..|:.|..|..|:
Mouse   326 RLHIPQFYLF---YDLSTVYSLLEKVKRIT-------VENSKV-FLVPCSFSQHLKSLEFLDLSE 379

  Fly   733 FVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPN--RIPQDVS 795
            .:...           ||.:         |.:|  ...|.:      .|.|....|  |..|...
Mouse   380 NLMVE-----------EYLK---------NSAC--KGAWPS------LQTLVLSQNHLRSMQKTG 416

  Fly   796 DLYLDGNNMPELEVGHLTGR---------RNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNK 851
            ::.|...|:..|::...|..         ..:|.|.|:::.:..::. .:.|  .|.||.:.||.
Mouse   417 EILLTLKNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKT-CIPQ--TLEVLDVSNNN 478

  Fly   852 LTALEGTEFRSLGL--LRELYLHNNMLTHISNATFEPLVSLEVLR------LDNNRLSSLPHLQY 908
            |.:.      ||.|  |:|||:..|.|..:.:|:..|::.:..:|      ...::|.|.|    
Mouse   479 LDSF------SLFLPRLQELYISRNKLKTLPDASLFPVLLVMKIRENAVSTFSKDQLGSFP---- 533

  Fly   909 RHSLQGLTLGRNAWSCRCQQLRELAQFVSDN---AMVVRDAHDIYCLDAGIKRELELIGNLANGP 970
              .|:.|..|.|.:.|.|    ||..|..:.   |.::.|..|.|..|:..:    |.|:     
Mouse   534 --KLETLEAGDNHFVCSC----ELLSFTMETPALAQILVDWPDSYLCDSPPR----LHGH----- 583

  Fly   971 DCSDLLDASASNISSSQ-DLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRM---WLFAHYGV 1031
               .|.||..|.:...| .|..|    :..|:|:||.||..|...|.....:||   ||.|....
Mouse   584 ---RLQDARPSVLECHQAALVSG----VCCALLLLILLVGALCHHFHGLWYLRMMWAWLQAKRKP 641

  Fly  1032 R------VCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHL 1090
            :      ||          |||.:.:||:|..:|...:..:||:..|||:||:.:||..|....:
Mouse   642 KKAPCRDVC----------YDAFVSYSEQDSHWVENLMVQQLENSDPPFKLCLHKRDFVPGKWII 696

  Fly  1091 -QLVEGARASRKIILVLTRNLLATEWNRIE-----FRNAFHESLRGLAQKLVIIEETSVSAEAED 1149
             .:::....|.|.:.||:.|.:.:||.:.|     || .|.|:  ..|..||::|.....|..:.
Mouse   697 DNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFR-LFDEN--NDAAILVLLEPIERKAIPQR 758

  Fly  1150 VAELSPYLKSVPSNRLLTCDRY------------FWEKLRYAI 1180
            ..:|         .:::....|            ||..||.||
Mouse   759 FCKL---------RKIMNTKTYLEWPLDEGQQEVFWVNLRTAI 792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:404697
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR 210..592 CDD:443914 63/244 (26%)
leucine-rich repeat 212..236 CDD:275380
leucine-rich repeat 237..260 CDD:275380
leucine-rich repeat 261..284 CDD:275380
leucine-rich repeat 285..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..358 CDD:275380
leucine-rich repeat 359..382 CDD:275380 6/22 (27%)
leucine-rich repeat 383..406 CDD:275380 7/22 (32%)
leucine-rich repeat 407..430 CDD:275380 7/22 (32%)
leucine-rich repeat 431..451 CDD:275380 7/21 (33%)
leucine-rich repeat 454..477 CDD:275380 8/23 (35%)
leucine-rich repeat 478..499 CDD:275380 2/20 (10%)
leucine-rich repeat 502..525 CDD:275380 5/22 (23%)
leucine-rich repeat 526..548 CDD:275380 8/25 (32%)
leucine-rich repeat 590..617 CDD:275380 3/26 (12%)
leucine-rich repeat 618..641 CDD:275380 6/22 (27%)
leucine-rich repeat 642..689 CDD:275380 9/50 (18%)
LRRCT 679..736 CDD:214507 11/56 (20%)
LRR <775..>920 CDD:443914 37/163 (23%)
leucine-rich repeat 775..796 CDD:275380 5/22 (23%)
leucine-rich repeat 797..817 CDD:275380 4/28 (14%)
leucine-rich repeat 818..841 CDD:275380 4/22 (18%)
leucine-rich repeat 842..865 CDD:275380 8/22 (36%)
leucine-rich repeat 866..889 CDD:275380 8/22 (36%)
leucine-rich repeat 890..911 CDD:275380 4/26 (15%)
TIR 1045..1183 CDD:214587 42/154 (27%)
Tlr2XP_006501523.1 LRR <53..305 CDD:443914 73/299 (24%)
leucine-rich repeat 65..87 CDD:275378 6/21 (29%)
leucine-rich repeat 88..111 CDD:275378 7/22 (32%)
leucine-rich repeat 112..135 CDD:275378 7/22 (32%)
leucine-rich repeat 136..160 CDD:275378 8/23 (35%)
leucine-rich repeat 186..212 CDD:275380 8/49 (16%)
leucine-rich repeat 213..233 CDD:275380 7/22 (32%)
LRR <345..>565 CDD:443914 60/274 (22%)
leucine-rich repeat 372..398 CDD:275380 8/47 (17%)
leucine-rich repeat 399..424 CDD:275380 6/24 (25%)
leucine-rich repeat 448..468 CDD:275380 4/22 (18%)
leucine-rich repeat 469..488 CDD:275380 9/24 (38%)
leucine-rich repeat 489..510 CDD:275380 7/20 (35%)
leucine-rich repeat 511..534 CDD:275380 4/28 (14%)
LRRCT 543..596 CDD:214507 17/68 (25%)
TIR 650..794 CDD:214587 43/165 (26%)
Blue background indicates that the domain is not in the aligned region.

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