DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and Tlr11

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_991388.2	Gene:	Tlr11 / 239081	MGIID:	3045226	Length:	931	Species:	Mus musculus

Alignment Length:	1170	Identity:	265/1170 - (22%)
Similarity:	404/1170 - (34%)	Gaps:	367/1170 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 APGLFRQLQKLSELRIDACKLQRVPPN----------------AFEGLMSLKRLTLESHNAVWGP 130
            |||| ..|...|.::.....|:|||.|                ||....||:.|.|:.
Mouse    62 APGL-HLLASCSNVKNLNQTLKRVPRNTEVLCLQGMVPTLPAKAFIRFHSLQLLRLQL------- 118

  Fly   131 GKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQN---RIRSAEFLGF--- 189
             :|..:..::||||.:|..|....:            .|....|.|:.|   .:||...|.|
Mouse   119 -RTTSVTSRTFQGLDQLQYLFFDHH------------APCCLSLFLSPNCFESLRSLSSLSFQGY 170

  Fly   190 ----SEKLCAGSALSN---ANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNI 247
                |:.:...::|.:   .|..::...:||         |..||.       .|.|.|
Mouse   171 CLTYSQSIYLPTSLRHLTLRNSCLTKFQDLQ---------RLFPDL-------LLSTSS------ 213

  Fly   248 STLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVL 312
               .||...|...|..|::||             |.:|::..::  |||.|   .||.    |:|
Mouse   214 ---TPNIKPGAPFLETLDLSY-------------NLQLKQAGVR--DLYGL---TLHS----LIL 253

  Fly   313 DLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKT--FKELYFLQILDMRNNSIGHIEEG 375
            |  |..|.:..:.:|   ||:.|..|:|....:.::.:..  :.|   |:.||:..|.|.:|.|.
Mouse   254 D--GTPLKALDLTDS---GLLHLHFLSLVGTGIEKVPASLTGYSE---LRALDLGKNQIQNILEN 310

  Fly   376 AFLPLYN-LHTLNLAENRLHTLDNRIFNGLYVLTKLTLN-NNLVSIVESQAFRNCSDLKELDLSS 438
            ..:|.|. |..|:|.:|.|.||..|..:.|..|.||.|: |.|..|:|.......::||.||||.
Mouse   311 GEIPGYKALEFLSLHDNHLQTLPTRFLHTLPQLQKLNLSMNKLGPILELPEGLFSTNLKVLDLSY 375

  Fly   439 NQLTEVPE-AVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRL 502
            |||.:||. |:..||.|:.|.|..|.||...|.:.:.|.||..|.|..|:|..:..|....||.|
Mouse   376 NQLCDVPHGALSLLSQLQELWLSGNNISSLSNESLQGLRQLRTLDLSWNQIKVLKPGWLSHLPAL 440

  Fly   503 SVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFI 567
            :.|||.         |.:                         |..:|.:.|..
Mouse   441 TTLNLL---------GTY-------------------------LEYILGIQLQG----------- 460

  Fly   568 PSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQ 632
            |..|:.|.        ||:|                 .|.:|.....|..:.|         :||
Mouse   461 PKMLRHLQ--------LGSY-----------------PILDIYPPWPPTLLSL---------EIQ 491

  Fly   633 ANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYL-GGNPFECDCSMEWLQRINNL 696
            |.:.:                                   :|.: .|.||         ..:.||
Mouse   492 AESCI-----------------------------------QFMIHSGQPF---------LFLENL 512

  Fly   697 TTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPG 761
            |......::...||....|..|...||..:.:.::..:.::.....|...
Mouse   513 TLETSILLLKPDNITIHFPSLRRLTLRGYSFIFSTSQLQRFFPQQLPLLE--------------- 562

  Fly   762 NCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLN-- 824
                 |...|..|                 ....||||.|  ||.|.|        |...|||
Mouse   563 -----HFFIWCEN-----------------SYAVDLYLFG--MPRLRV--------LELGYLNFF 595

  Fly   825 -ASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLV 888
             .|:.|.|:. .|.::..|:||.|.:..|..|..:.|:||..|: |.|.|
Mouse   596 YESSTMKLEM-LLKEVPQLQVLALSHLNLRNLSVSSFKSLQDLK-LLLFN--------------- 643

  Fly   889 SLEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLD 953
            |...|.:::|....:|.:........:|     ::|:|:     |.::...|....:.. :|.|:
Mouse   644 SERALEMNSNLQEFIPQMPQYVYFSDVT-----FTCQCE-----ASWLESWATRAPNTF-VYGLE 697

  Fly   954 AGIKRELELIGNLANGPDCSDLLDAS--ASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFV 1016
            ..|        .:||..|.|..|..|  |:|.....:..|     .|.:.::|:.|:::.:|
Mouse   698 KSI--------CIANASDYSKTLLFSFLATNCPHGTEFWG-----FLTSFILLLLLIILPLI--- 746

  Fly  1017 FRESVRMWLFAHY--------GVRVCEPRFEDAGKL-YDAIILHSEKDYEFVCRNIAAELEHGRP 1072
               |...|.:.|:        ..::|..|..  |:. ||..|.:.|:|..:|...:...||...|
Mouse   747 ---SCPKWSWLHHLWTLFHTCWWKLCGHRLR--GQFNYDVFISYCEEDQAWVLEELVPVLEKAPP 806

  Fly  1073 P---FRLCIQQRDLPPQASHLQ-LVEGARASRKIILVLTRNLLATEWNRIEFRNA-FHESLR-GL 1131
            .   .|||:..||.......:: ::.....||..:.|||...||:.|..:|.|.| :|...| |.
Mouse   807 EGEGLRLCLPARDFGIGNDRMESMIASMGKSRATLCVLTGQALASPWCNLELRLATYHLVARPGT 871

  Fly  1132 AQKLVIIEETSVSAEAEDVAELSPYLKSVPSNRLLTCDRYF--------WEKLRYAIPIELSPRG 1188
            ...|::..|............||.:|:.         :.||        |......:...||..|
Mouse   872 THLLLLFLEPLDRQRLHSYHRLSRWLQK---------EDYFDLSQGKVEWNSFCEQLKRRLSKAG 927

Fly 1189 1188
Mouse 928 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380	5/8 (63%)
		leucine-rich repeat	92..115	CDD:275380	8/38 (21%)
		LRR_8	115..181	CDD:290566	15/68 (22%)
		leucine-rich repeat	116..146	CDD:275380	8/29 (28%)
		leucine-rich repeat	147..170	CDD:275380	2/22 (9%)
		leucine-rich repeat	171..201	CDD:275380	9/39 (23%)
		LRR_RI	210..464	CDD:238064	79/258 (31%)
		leucine-rich repeat	212..236	CDD:275380	5/23 (22%)
		LRR_8	235..295	CDD:290566	12/59 (20%)
		leucine-rich repeat	237..260	CDD:275380	6/22 (27%)
		leucine-rich repeat	261..284	CDD:275380	5/22 (23%)
		LRR_8	283..345	CDD:290566	18/61 (30%)
		leucine-rich repeat	285..308	CDD:275380	7/22 (32%)
		leucine-rich repeat	309..334	CDD:275380	8/24 (33%)
		LRR_8	334..393	CDD:290566	17/61 (28%)
		leucine-rich repeat	335..358	CDD:275380	4/24 (17%)
		leucine-rich repeat	359..382	CDD:275380	8/22 (36%)
		LRR_8	382..441	CDD:290566	24/60 (40%)
		leucine-rich repeat	383..406	CDD:275380	9/22 (41%)
		leucine-rich repeat	407..430	CDD:275380	8/23 (35%)
		LRR_8	431..488	CDD:290566	27/57 (47%)
		leucine-rich repeat	431..451	CDD:275380	12/20 (60%)
		leucine-rich repeat	454..477	CDD:275380	8/22 (36%)
		LRR_8	477..559	CDD:290566	17/81 (21%)
		leucine-rich repeat	478..499	CDD:275380	6/20 (30%)
		leucine-rich repeat	502..525	CDD:275380	5/22 (23%)
		leucine-rich repeat	526..548	CDD:275380	1/21 (5%)
		leucine-rich repeat	590..617	CDD:275380	3/26 (12%)
		leucine-rich repeat	618..641	CDD:275380	4/22 (18%)
		leucine-rich repeat	642..689	CDD:275380	4/47 (9%)
		LRRCT	679..736	CDD:214507	11/56 (20%)
		leucine-rich repeat	775..796	CDD:275380	0/20 (0%)
		LRR_8	797..852	CDD:290566	20/57 (35%)
		leucine-rich repeat	797..817	CDD:275380	8/19 (42%)
		leucine-rich repeat	818..841	CDD:275380	8/25 (32%)
		LRR_8	841..900	CDD:290566	16/58 (28%)
		leucine-rich repeat	842..865	CDD:275380	9/22 (41%)
		LRR_4	866..907	CDD:289563	8/40 (20%)
		leucine-rich repeat	866..889	CDD:275380	4/22 (18%)
		leucine-rich repeat	890..911	CDD:275380	3/20 (15%)
		TIR	1045..1183	CDD:214587	36/151 (24%)
Tlr11	NP_991388.2	LRR_RI	<184..427	CDD:238064	90/297 (30%)
		leucine-rich repeat	224..246	CDD:275380	9/36 (25%)
		leucine-rich repeat	248..270	CDD:275380	10/30 (33%)
		leucine-rich repeat	271..293	CDD:275380	3/21 (14%)
		leucine-rich repeat	294..318	CDD:275380	9/23 (39%)
		LRR_8	319..378	CDD:290566	24/58 (41%)
		leucine-rich repeat	319..342	CDD:275380	9/22 (41%)
		leucine-rich repeat	343..367	CDD:275380	8/23 (35%)
		LRR_8	366..426	CDD:290566	27/59 (46%)
		leucine-rich repeat	368..391	CDD:275380	13/22 (59%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		LRR_8	414..471	CDD:290566	21/109 (19%)
		leucine-rich repeat	416..437	CDD:275380	6/20 (30%)
		leucine-rich repeat	440..463	CDD:275380	9/67 (13%)
		TIR_2	781..>861	CDD:290400	22/79 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920