DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Nrros

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_666181.3 Gene:Nrros / 224109 MGIID:2445095 Length:693 Species:Mus musculus


Alignment Length:875 Identity:216/875 - (24%)
Similarity:321/875 - (36%) Gaps:259/875 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   193 LCAG---------SALSNANGAVSGGSEL--QTLDVSFNELRSLPDAWGA-SRLRRLQTLSLQHN 245
            ||.|         |....|..|..||.::  ...|.....|.|:|.:... ||:     |.|..|
Mouse     8 LCLGFHFLIVEWRSGPGTATAASQGGCKVVDGVADCRGLNLASVPSSLPPHSRM-----LILDAN 67

  Fly   246 NISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDL---YELPKGLLHRLE 307
            .:..|..::|.....|..|::...||..:...||.....||.|.|..|.|   |:.....||.|.
Mouse    68 PLKDLWNHSLQAYPRLENLSLHSCHLDRISHYAFREQGHLRNLVLADNRLSENYKESAAALHTLL 132

  Fly   308 QLLVLDLSGNQLTSHHVDNST--FAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIG 370
            .|..||||||.||.   |.:.  ...|..|.|::|:.|.|.|:....|:.|..|..||::.|.|.
Mouse   133 GLRRLDLSGNSLTE---DMAALMLQNLSSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIF 194

  Fly   371 HIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIV-------ESQAFRNC 428
            .||.|||..|..|..||||.|.|..:.:      :.||:|...|...:|:       |..||   
Mouse   195 EIEGGAFDGLTELRRLNLAYNNLPCIVD------FSLTQLRFLNVSYNILEWFLAAREEVAF--- 250

  Fly   429 SDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKN--NTFRNLNQLTGLRLIDNRIGNI 491
             :|:.||||.|||...| .:.....|.||.|.:|.:..::.  ||......:....|:|..:.||
Mouse   251 -ELEILDLSHNQLLFFP-LLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNI 313

  Fly   492 -TVGMFQ-----DLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLL 550
             ||.:::     ||..|..|::::|:.:.:..| |.|.|                      .||.
Mouse   314 TTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDG-FLKKT----------------------PSLS 355

  Fly   551 WLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIG-AMSV 614
            .|||::|            .||.|.|..:  |..|         .:|.||.|||::.|:. |..:
Mouse   356 HLNLNQN------------CLKMLHIREH--EPPG---------ALTELDLSHNQLAELHLAPGL 397

  Fly   615 PNSIELLFI----NNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFY 675
            ..|:..|.:    :|.::| :....|.:.:.:..:|:..|   :||| ..::.||..|.|     
Mouse   398 TGSLRNLRVFNLSSNQLLG-VPTGLFDNASSITTIDMSHN---QISL-CPQMVPVDWEGP----- 452

  Fly   676 LGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESH 740
                                      |..||..|            :..|.|||           
Mouse   453 --------------------------PSCVDFRN------------MGSLRSLS----------- 468

  Fly   741 CPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMP 805
                                              :..||.:.|...|           ..|.::.
Mouse   469 ----------------------------------LDGCGLKALQDCP-----------FQGTSLT 488

  Fly   806 ELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQL----VNLRVLHLENNKL-TALEGTEFRSLGL 865
            .|::               :||...| |||::.|    ..|:||.|.:..| :.....:|.:.|.
Mouse   489 HLDL---------------SSNWGVL-NGSISPLWAVAPTLQVLSLRDVGLGSGAAEMDFSAFGN 537

  Fly   866 LRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHL----QYRHSLQGLTLGRNAWSCRC 926
            ||.|.|..|.||  |...|:..::|..|.|..|.|::||..    |....||.:.|.:|.:.| |
Mouse   538 LRALDLSGNSLT--SFPKFKGSLALRTLDLRRNSLTALPQRVVSEQPLRGLQTIYLSQNPYDC-C 599

  Fly   927 -----QQLRELAQFVSDNAMVVRDAHDIYC-LDAGIKRELELIGNLANGPDCSDLLDASASNISS 985
                 ..|::..:.|:|.:||.       | |.:.|.|.:||...|..|.....:          
Mouse   600 GVEGWGALQQHFKTVADLSMVT-------CNLSSKIVRVVELPEGLPQGCKWEQV---------- 647

  Fly   986 SQDLAGGYRLPLLAAVLVLIFLVVVLIIVF 1015
              |....|.:.:|.:.|.|:....|:.:.|
Mouse   648 --DTGLFYLVLILPSCLTLLVACTVVFLTF 675

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:404697
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380 4/16 (25%)
LRR 210..592 CDD:443914 115/404 (28%)
leucine-rich repeat 212..236 CDD:275380 6/26 (23%)
leucine-rich repeat 237..260 CDD:275380 5/22 (23%)
leucine-rich repeat 261..284 CDD:275380 6/22 (27%)
leucine-rich repeat 285..308 CDD:275380 10/25 (40%)
leucine-rich repeat 309..334 CDD:275380 11/26 (42%)
leucine-rich repeat 335..358 CDD:275380 8/22 (36%)
leucine-rich repeat 359..382 CDD:275380 11/22 (50%)
leucine-rich repeat 383..406 CDD:275380 7/22 (32%)
leucine-rich repeat 407..430 CDD:275380 8/29 (28%)
leucine-rich repeat 431..451 CDD:275380 9/19 (47%)
leucine-rich repeat 454..477 CDD:275380 7/24 (29%)
leucine-rich repeat 478..499 CDD:275380 6/26 (23%)
leucine-rich repeat 502..525 CDD:275380 6/22 (27%)
leucine-rich repeat 526..548 CDD:275380 0/21 (0%)
leucine-rich repeat 590..617 CDD:275380 8/27 (30%)
leucine-rich repeat 618..641 CDD:275380 4/26 (15%)
leucine-rich repeat 642..689 CDD:275380 9/46 (20%)
LRRCT 679..736 CDD:214507 8/56 (14%)
LRR <775..>920 CDD:443914 40/153 (26%)
leucine-rich repeat 775..796 CDD:275380 4/20 (20%)
leucine-rich repeat 797..817 CDD:275380 2/19 (11%)
leucine-rich repeat 818..841 CDD:275380 7/26 (27%)
leucine-rich repeat 842..865 CDD:275380 6/23 (26%)
leucine-rich repeat 866..889 CDD:275380 9/22 (41%)
leucine-rich repeat 890..911 CDD:275380 8/24 (33%)
TIR 1045..1183 CDD:214587
NrrosNP_666181.3 LRR 1. /evidence=ECO:0000255 58..79 7/25 (28%)
leucine-rich repeat 60..82 CDD:275380 6/26 (23%)
LRR 2. /evidence=ECO:0000255 82..103 6/20 (30%)
leucine-rich repeat 83..106 CDD:275380 6/22 (27%)
LRR <106..414 CDD:443914 109/367 (30%)
LRR 3. /evidence=ECO:0000255 106..127 7/20 (35%)
leucine-rich repeat 107..133 CDD:275380 10/25 (40%)
LRR 4. /evidence=ECO:0000255 133..155 10/24 (42%)
leucine-rich repeat 134..158 CDD:275380 11/26 (42%)
LRR 5. /evidence=ECO:0000255 158..179 7/20 (35%)
leucine-rich repeat 159..182 CDD:275380 8/22 (36%)
LRR 6. /evidence=ECO:0000255 182..203 10/20 (50%)
leucine-rich repeat 183..206 CDD:275380 11/22 (50%)
LRR 7. /evidence=ECO:0000255 206..227 8/26 (31%)
leucine-rich repeat 207..251 CDD:275380 15/53 (28%)
LRR 8. /evidence=ECO:0000255 228..239 3/10 (30%)
leucine-rich repeat 230..249 CDD:275380 3/18 (17%)
LRR 9. /evidence=ECO:0000255 251..272 9/21 (43%)
leucine-rich repeat 252..273 CDD:275380 9/21 (43%)
LRR 10. /evidence=ECO:0000255 273..294 6/20 (30%)
leucine-rich repeat 274..329 CDD:275380 15/54 (28%)
LRR 276..>595 CDD:443914 103/486 (21%)
LRR 11. /evidence=ECO:0000255 329..350 5/21 (24%)
leucine-rich repeat 330..353 CDD:275380 7/45 (16%)
LRR 12. /evidence=ECO:0000255 353..374 10/34 (29%)
leucine-rich repeat 354..377 CDD:275380 11/45 (24%)
LRR 13. /evidence=ECO:0000255 377..398 8/20 (40%)
leucine-rich repeat 378..403 CDD:275380 9/24 (38%)
LRR 14. /evidence=ECO:0000255 403..424 4/21 (19%)
leucine-rich repeat 404..427 CDD:275380 4/23 (17%)
LRR 15. /evidence=ECO:0000255 427..448 6/24 (25%)
leucine-rich repeat 428..463 CDD:275380 13/81 (16%)
LRR 16. /evidence=ECO:0000255 463..484 8/76 (11%)
leucine-rich repeat 464..486 CDD:275380 9/77 (12%)
LRR 17. /evidence=ECO:0000255 486..507 7/36 (19%)
leucine-rich repeat 487..512 CDD:275380 8/40 (20%)
LRR 18. /evidence=ECO:0000255 512..533 5/20 (25%)
leucine-rich repeat 513..537 CDD:275380 6/23 (26%)
LRR 19. /evidence=ECO:0000255 537..558 9/22 (41%)
leucine-rich repeat 538..559 CDD:275380 9/22 (41%)
LRR 20. /evidence=ECO:0000255 559..580 7/20 (35%)
LRR 21. /evidence=ECO:0000255 585..605 6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

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