DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Tlr4

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_067272.1 Gene:Tlr4 / 21898 MGIID:96824 Length:835 Species:Mus musculus


Alignment Length:1107 Identity:232/1107 - (20%)
Similarity:376/1107 - (33%) Gaps:414/1107 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 DNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVS 218
            |..:.::|:.:..|..::.|.......::|..|..|                    ||||.||:|
Mouse    41 DQKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNF--------------------SELQWLDLS 85

  Fly   219 FNELRSLPD-AWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGN 282
            ..|:.::.| ||..  |..|..|.|..|.|.:.:|.:.:||:||..|......|.||.|      
Mouse    86 RCEIETIEDKAWHG--LHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLES------ 142

  Fly   283 KELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNST-----FAGLIRLIVLNLSN 342
                           .|.|.|..|::|.|         :|:..:|.     |:.|..|:.::||.
Mouse   143 ---------------FPIGQLITLKKLNV---------AHNFIHSCKLPAYFSNLTNLVHVDLSY 183

  Fly   343 NALTRIGSKTFKELYFLQ-------ILDMRNNSIGHIEEGAFLPLYNLHTL-------------- 386
            |.:..|   |..:|.||:       .|||..|.|..|::.||..: .||.|              
Mouse   184 NYIQTI---TVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGI-KLHELTLRGNFNSSNIMKT 244

  Fly   387 ---NLAENRLHTL------DNR--------IFNGLYVLT----KLTLNNNLV-SIVESQAFRNCS 429
               |||...:|.|      |.|        |..||..:|    :||..|:.. .||:.....|.|
Mouse   245 CLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVS 309

  Fly   430 DLKELDLSSNQLTEVPEAV--QDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNIT 492
            .:....:|...|.:||:..  |.||:::.      |:.:|..                       
Mouse   310 AMSLAGVSIKYLEDVPKHFKWQSLSIIRC------QLKQFPT----------------------- 345

  Fly   493 VGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSEN 557
                .|||.|..|.|..|: .||   :|.|                     ..|.||.:|:||.|
Mouse   346 ----LDLPFLKSLTLTMNK-GSI---SFKK---------------------VALPSLSYLDLSRN 381

  Fly   558 HLVW---FDYAFIPSN-LKWLDIHGN-YIEALGNYYKLQEEIRVTTLDASHN---RITEIGAMSV 614
            .|.:   ..|:.:.:| |:.||:..| .|....|:..|:|   :..||..|:   |:||..|.. 
Mouse   382 ALSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEE---LQHLDFQHSTLKRVTEFSAFL- 442

  Fly   615 PNSIE-LLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGG 678
              |:| ||:::.:     ..||        ::|.....|...|||.|::|              |
Mouse   443 --SLEKLLYLDIS-----YTNT--------KIDFDGIFLGLTSLNTLKMA--------------G 478

  Fly   679 NPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPP 743
            |.|:.:..........|||      .:||                                    
Mouse   479 NSFKDNTLSNVFANTTNLT------FLDL------------------------------------ 501

  Fly   744 TCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELE 808
                   .:|:.|.|..|.....|                                         
Mouse   502 -------SKCQLEQISWGVFDTLH----------------------------------------- 518

  Fly   809 VGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHN 873
                    .|:.|.::.:||:.|.:....||.:|..|....|::...:|                
Mouse   519 --------RLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKG---------------- 559

  Fly   874 NMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSD 938
             :|.|...       ||....|.||.:                      :|.|:. ::..|:|.:
Mouse   560 -ILQHFPK-------SLAFFNLTNNSV----------------------ACICEH-QKFLQWVKE 593

  Fly   939 NAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLV 1003
            ....:.:...:.|     ...:|:        :.|.:||.:.|..         |....:.:|.|
Mouse   594 QKQFLVNVEQMTC-----ATPVEM--------NTSLVLDFNNSTC---------YMYKTIISVSV 636

  Fly  1004 LIFLVVVLIIVFVFRESVRMWLFAHYGVRVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELE 1068
            :..:||..:...::.....:.|.|.     |: ::.....:|||.:::|.::.::|...:...||
Mouse   637 VSVIVVSTVAFLIYHFYFHLILIAG-----CK-KYSRGESIYDAFVIYSSQNEDWVRNELVKNLE 695

  Fly  1069 HGRPPFRLCIQQRDLPP----QASHLQLVEGARASRKIILVLTRNLLATEWNRIEFRNA----FH 1125
            .|.|.|.||:..||..|    .|:.:|  ||...|||:|:|::|:.:.:.|...|:..|    |.
Mouse   696 EGVPRFHLCLHYRDFIPGVAIAANIIQ--EGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFL 758

  Fly  1126 ESLRGLAQKLVIIEETSVSAEAEDVAELSPYLKSVPSNRLLTCDRY------------FWEKLRY 1178
            .|..|:.  .:::|:          .|.|...:.|...|||:.:.|            ||.:|:.
Mouse   759 SSRSGII--FIVLEK----------VEKSLLRQQVELYRLLSRNTYLEWEDNPLGRHIFWRRLKN 811

  Fly  1179 AI 1180
            |:
Mouse   812 AL 813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566 4/26 (15%)
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380 3/15 (20%)
leucine-rich repeat 171..201 CDD:275380 4/29 (14%)
LRR_RI 210..464 CDD:238064 82/304 (27%)
leucine-rich repeat 212..236 CDD:275380 10/24 (42%)
LRR_8 235..295 CDD:290566 15/59 (25%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 6/22 (27%)
LRR_8 283..345 CDD:290566 14/66 (21%)
leucine-rich repeat 285..308 CDD:275380 4/22 (18%)
leucine-rich repeat 309..334 CDD:275380 6/29 (21%)
LRR_8 334..393 CDD:290566 23/82 (28%)
leucine-rich repeat 335..358 CDD:275380 7/22 (32%)
leucine-rich repeat 359..382 CDD:275380 9/29 (31%)
LRR_8 382..441 CDD:290566 22/94 (23%)
leucine-rich repeat 383..406 CDD:275380 13/53 (25%)
leucine-rich repeat 407..430 CDD:275380 7/27 (26%)
LRR_8 431..488 CDD:290566 9/58 (16%)
leucine-rich repeat 431..451 CDD:275380 5/21 (24%)
leucine-rich repeat 454..477 CDD:275380 2/22 (9%)
LRR_8 477..559 CDD:290566 18/81 (22%)
leucine-rich repeat 478..499 CDD:275380 0/20 (0%)
leucine-rich repeat 502..525 CDD:275380 8/22 (36%)
leucine-rich repeat 526..548 CDD:275380 1/21 (5%)
leucine-rich repeat 590..617 CDD:275380 9/29 (31%)
leucine-rich repeat 618..641 CDD:275380 5/23 (22%)
leucine-rich repeat 642..689 CDD:275380 10/46 (22%)
LRRCT 679..736 CDD:214507 7/56 (13%)
leucine-rich repeat 775..796 CDD:275380 0/20 (0%)
LRR_8 797..852 CDD:290566 10/54 (19%)
leucine-rich repeat 797..817 CDD:275380 0/19 (0%)
leucine-rich repeat 818..841 CDD:275380 7/22 (32%)
LRR_8 841..900 CDD:290566 11/58 (19%)
leucine-rich repeat 842..865 CDD:275380 4/22 (18%)
LRR_4 866..907 CDD:289563 7/40 (18%)
leucine-rich repeat 866..889 CDD:275380 2/22 (9%)
leucine-rich repeat 890..911 CDD:275380 4/20 (20%)
TIR 1045..1183 CDD:214587 43/156 (28%)
Tlr4NP_067272.1 LRR_8 53..113 CDD:290566 21/81 (26%)
LRR 1 54..75 4/20 (20%)
leucine-rich repeat 58..78 CDD:275380 4/39 (10%)
LRR 2 78..99 10/20 (50%)
leucine-rich repeat 79..102 CDD:275380 10/24 (42%)
LRR 3 102..123 6/20 (30%)
leucine-rich repeat 103..126 CDD:275380 8/22 (36%)
LRR 4 126..147 8/41 (20%)
leucine-rich repeat 127..150 CDD:275380 9/43 (21%)
LRR_8 150..214 CDD:290566 20/75 (27%)
LRR 5 150..171 5/29 (17%)
leucine-rich repeat 151..175 CDD:275380 7/32 (22%)
LRR 6 175..198 8/25 (32%)
leucine-rich repeat 176..204 CDD:275380 9/30 (30%)
LRR 7 204..224 8/19 (42%)
leucine-rich repeat 205..226 CDD:275380 8/21 (38%)
LRR 8 226..247 3/20 (15%)
LRR 9 248..269 7/20 (35%)
LRR 10 329..349 6/52 (12%)
leucine-rich repeat 331..350 CDD:275380 7/51 (14%)
LRR 11 350..370 8/44 (18%)
leucine-rich repeat 351..372 CDD:275380 9/45 (20%)
LRR_RI <369..555 CDD:238064 61/316 (19%)
LRR 12 372..392 7/19 (37%)
leucine-rich repeat 373..398 CDD:275380 7/24 (29%)
LRR 13 398..420 6/21 (29%)
leucine-rich repeat 399..421 CDD:275380 7/21 (33%)
LRR 14 421..442 8/23 (35%)
leucine-rich repeat 422..446 CDD:275380 8/26 (31%)
LRR 15 446..467 5/33 (15%)
leucine-rich repeat 447..470 CDD:275380 6/35 (17%)
LRR 16 470..490 8/33 (24%)
leucine-rich repeat 471..495 CDD:275380 7/37 (19%)
LRR_8 494..554 CDD:290566 20/157 (13%)
LRR 17 495..516 9/69 (13%)
leucine-rich repeat 496..519 CDD:275380 9/120 (8%)
LRR 18 519..540 5/20 (25%)
leucine-rich repeat 520..543 CDD:275380 7/22 (32%)
LRR 19 543..564 5/37 (14%)
Interaction with SCIMP. /evidence=ECO:0000269|PubMed:28098138 670..835 43/158 (27%)
TIR 672..813 CDD:214587 42/154 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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