DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Tlr1

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001263374.1 Gene:Tlr1 / 21897 MGIID:1341295 Length:795 Species:Mus musculus


Alignment Length:1008 Identity:215/1008 - (21%)
Similarity:343/1008 - (34%) Gaps:320/1008 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   239 TLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLL 303
            ||.|..||||.|..:.:..||.||||.:|||.|..|....|..|.||..|.|..|:|..:   |.
Mouse    52 TLDLSQNNISELQTSDILSLSKLRVLIMSYNRLQYLNISVFKFNTELEYLDLSHNELKVI---LC 113

  Fly   304 HRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNS 368
            |....|..||||.|...:..:... |..:.:|..|.||.:.:.....:....|...::|.:..::
Mouse   114 HPTVSLKHLDLSFNAFDALPICKE-FGNMSQLQFLGLSGSRVQSSSVQLIAHLNISKVLLVLGDA 177

  Fly   369 IGHIEEGAFLPLYNLHTLNLA--ENRLHTLDNRIFNGLYVLTKLTLN-NNLVSIVESQAFRNCSD 430
            .|..|:...|...:..||::.  ..|    :.|....:.|.|.:.|. :|:..::|.|   .|| 
Mouse   178 YGEKEDPESLRHVSTETLHIVFPSKR----EFRFLLDVSVSTTIGLELSNIKCVLEDQ---GCS- 234

  Fly   431 LKELDLSSNQLTEVPEAVQDLSMLKTLD-LGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVG 494
                                 ..|:.|. ||:|                                
Mouse   235 ---------------------YFLRALSKLGKN-------------------------------- 246

  Fly   495 MFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHL 559
                   |.:.||..|.::                       |..|. |..:..::|    ...:
Mouse   247 -------LKLSNLTLNNVE-----------------------TTWNS-FINILQIVW----HTPV 276

  Fly   560 VWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDA--SHNRITEIGAMSVPNS-IELL 621
            .:|..    ||:|   :.|.....:.||..       |:|.|  .|..:|::  .|.|.| |..:
Mouse   277 KYFSI----SNVK---LQGQLAFRMFNYSD-------TSLKALSIHQVVTDV--FSFPQSYIYSI 325

  Fly   622 FINNNIIGQIQANTFV-------DKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGN 679
            |.|.||.....:.|.:       ..:....||...|:|:.:...                     
Mouse   326 FANMNIQNFTMSGTHMVHMLCPSQVSPFLHVDFTDNLLTDMVFK--------------------- 369

  Fly   680 PFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPT 744
                ||..  |.|:..|:.:::    .|.|:|.::  ..||.:..|..|..|....:|..     
Mouse   370 ----DCRN--LVRLKTLSLQKN----QLKNLENII--LTSAKMTSLQKLDISQNSLRYSD----- 417

  Fly   745 CHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEV 809
                            |...|    .|..::                                  
Mouse   418 ----------------GGIPC----AWTQSL---------------------------------- 428

  Fly   810 GHLTGRRNLRALYLN-ASNLMTLQNGSLAQLV--NLRVLHLENNKLTALEGTEFRSLGLLRELYL 871
                       |.|| :||::|   ||:.:.:  .::||.|.||::.::. .:...|..|:||.:
Mouse   429 -----------LVLNLSSNMLT---GSVFRCLPPKVKVLDLHNNRIMSIP-KDVTHLQALQELNV 478

  Fly   872 HNNMLTHISN-ATFEPLVSLEVLRLDNNRLS--SLPHLQYRHSLQGLTLGRNAWSCRCQQLRELA 933
            .:|.||.:.. ..|.   ||.||.:|:|.:|  |....|...:::.||.|.|.:.|.|    ||.
Mouse   479 ASNSLTDLPGCGAFS---SLSVLVIDHNSVSHPSEDFFQSCQNIRSLTAGNNPFQCTC----ELR 536

  Fly   934 QFVSDNAMVVRDA----HDIYCLDAGIKRELELIGNLANGPDCS---DLLDASASNISSSQDLAG 991
            .||.:...|.|:.    .|.|..|.               |:.|   .|.|...|.:|....|  
Mouse   537 DFVKNIGWVAREVVEGWPDSYRCDY---------------PESSRGTALRDFHMSPLSCDTVL-- 584

  Fly   992 GYRLPLLAAVLVLIFLVVVLIIVFVFRESVRM---WLFAHYGVRVCEPRFEDAGKLYDAIILHSE 1053
             ..:.:.|.:|||......|.:.|.....|||   |....:..|............:.|.:.:|.
Mouse   585 -LTVTIGATMLVLAVTGAFLCLYFDLPWYVRMLCQWTQTRHRARHIPLEELQRNLQFHAFVSYSG 648

  Fly  1054 KDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHLQ-LVEGARASRKIILVLTRNLLATEWNR 1117
            .|..:|...:...||  :...::|:.:|:..|..|.:: ::.....|.|.|.||:.:.:.:||..
Mouse   649 HDSAWVKNELLPNLE--KDDIQICLHERNFVPGKSIVENIINFIEKSYKSIFVLSPHFIQSEWCH 711

  Fly  1118 IEF----RNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYLKSVPSN-----RLLTCDRY-- 1171
            .|.    .|.|||.    :..|::|.          :|.:..|  |:|:|     .|::...|  
Mouse   712 YELYFAHHNLFHEG----SDNLILIL----------LAPIPQY--SIPTNYHKLKTLMSRRTYLE 760

  Fly  1172 ----------FWEKLRYAIPIEL--SPRGNNYT 1192
                      ||..||.:|.::|  ...|..||
Mouse   761 WPTEKNKHGLFWANLRASINVKLVNQAEGTCYT 793

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR_RI 210..464 CDD:238064 62/228 (27%)
leucine-rich repeat 212..236 CDD:275380
LRR_8 235..295 CDD:290566 26/55 (47%)
leucine-rich repeat 237..260 CDD:275380 9/20 (45%)
leucine-rich repeat 261..284 CDD:275380 11/22 (50%)
LRR_8 283..345 CDD:290566 19/61 (31%)
leucine-rich repeat 285..308 CDD:275380 7/22 (32%)
leucine-rich repeat 309..334 CDD:275380 7/24 (29%)
LRR_8 334..393 CDD:290566 11/60 (18%)
leucine-rich repeat 335..358 CDD:275380 5/22 (23%)
leucine-rich repeat 359..382 CDD:275380 4/22 (18%)
LRR_8 382..441 CDD:290566 12/61 (20%)
leucine-rich repeat 383..406 CDD:275380 4/24 (17%)
leucine-rich repeat 407..430 CDD:275380 6/23 (26%)
LRR_8 431..488 CDD:290566 5/57 (9%)
leucine-rich repeat 431..451 CDD:275380 0/19 (0%)
leucine-rich repeat 454..477 CDD:275380 5/23 (22%)
LRR_8 477..559 CDD:290566 8/81 (10%)
leucine-rich repeat 478..499 CDD:275380 0/20 (0%)
leucine-rich repeat 502..525 CDD:275380 4/22 (18%)
leucine-rich repeat 526..548 CDD:275380 3/21 (14%)
leucine-rich repeat 590..617 CDD:275380 7/28 (25%)
leucine-rich repeat 618..641 CDD:275380 6/29 (21%)
leucine-rich repeat 642..689 CDD:275380 6/46 (13%)
LRRCT 679..736 CDD:214507 13/56 (23%)
leucine-rich repeat 775..796 CDD:275380 0/20 (0%)
LRR_8 797..852 CDD:290566 13/57 (23%)
leucine-rich repeat 797..817 CDD:275380 0/19 (0%)
leucine-rich repeat 818..841 CDD:275380 8/25 (32%)
LRR_8 841..900 CDD:290566 19/59 (32%)
leucine-rich repeat 842..865 CDD:275380 6/22 (27%)
LRR_4 866..907 CDD:289563 15/43 (35%)
leucine-rich repeat 866..889 CDD:275380 7/23 (30%)
leucine-rich repeat 890..911 CDD:275380 8/22 (36%)
TIR 1045..1183 CDD:214587 36/159 (23%)
Tlr1NP_001263374.1 PRK15370 <38..>133 CDD:185268 35/83 (42%)
LRR <48..317 CDD:227223 82/380 (22%)
leucine-rich repeat 50..73 CDD:275378 9/20 (45%)
LRR 1 54..77 10/22 (45%)
leucine-rich repeat 74..97 CDD:275378 11/22 (50%)
LRR 2 78..101 9/22 (41%)
leucine-rich repeat 98..118 CDD:275378 7/22 (32%)
LRR 3 102..125 8/25 (32%)
leucine-rich repeat 119..143 CDD:275378 7/24 (29%)
LRR 4 126..150 4/24 (17%)
leucine-rich repeat 144..156 CDD:275378 4/11 (36%)
LRR 5 151..175 2/23 (9%)
LRR 6 176..199 5/22 (23%)
LRR 7 200..223 5/26 (19%)
LRR 8 224..250 10/89 (11%)
LRR 9 251..278 7/54 (13%)
LRR 10 279..308 10/42 (24%)
LRR 11 309..337 9/29 (31%)
Interaction with bacterial lipopeptide. /evidence=ECO:0000250 316..319 1/2 (50%)
LRR 12 338..361 3/22 (14%)
leucine-rich repeat 355..376 CDD:275380 7/47 (15%)
LRR 13 362..388 6/56 (11%)
PRK15370 <377..>487 CDD:185268 33/189 (17%)
leucine-rich repeat 377..402 CDD:275380 6/30 (20%)
LRR 14 389..414 7/26 (27%)
leucine-rich repeat 403..427 CDD:275380 7/48 (15%)
LRR 15 415..437 8/91 (9%)
leucine-rich repeat 428..449 CDD:275380 8/68 (12%)
LRR 16 438..457 6/21 (29%)
leucine-rich repeat 450..472 CDD:275380 6/22 (27%)
LRR 17 458..478 5/20 (25%)
leucine-rich repeat 473..494 CDD:275380 7/23 (30%)
LRR 18 479..500 8/23 (35%)
leucine-rich repeat 495..518 CDD:275380 8/22 (36%)
LRR 19 501..524 6/22 (27%)
LRRCT 527..581 CDD:214507 18/72 (25%)
TIR 639..782 CDD:214587 36/160 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.820

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