DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and let-4

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_510425.2 Gene:let-4 / 181554 WormBaseID:WBGene00002282 Length:773 Species:Caenorhabditis elegans


Alignment Length:871 Identity:187/871 - (21%)
Similarity:332/871 - (38%) Gaps:229/871 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 CLL----LLVADAHAQQQCNWQYGLTTMDIRCSVRALESGTGTPLDLQVAEAAGRLDLQCSQELL 76
            |||    ||:...:|   |.   |:.|....||    |..:|..||...:.|:|.|      :::
 Worm     6 CLLLFSTLLINSTNA---CP---GVITQACFCS----EVHSGIVLDCSNSSASGIL------QII 54

  Fly    77 HASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSF 141
            ..::...||      :..|.::..:|..:|||.|.||. ::||.|..:       |..::...:|
 Worm    55 RTNQAQVGL------IQSLTMNQAELVELPPNFFSGLF-IRRLDLSQN-------KIKKIDDAAF 105

  Fly   142 QGLKE-LSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGA 205
            .|:.. |.|:.|..|.|.::|......:|:|..|:|:.|.|                        
 Worm   106 AGINPVLEEVVLNHNLIEKVPAAALAGLPNLLRLDLSNNSI------------------------ 146

  Fly   206 VSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGL-SSLRVLNISYN 269
                       |...|....|:      |.:|..::|..|.|.::..:....: :|::.:|:.:|
 Worm   147 -----------VEIQEQEIFPN------LNKLYDINLGSNKIFSIHTSTFQNVKNSIQTINLGHN 194

  Fly   270 HLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIR 334
            ::.::||.|..|.|:|:.|||..|           |:|||..|:                     
 Worm   195 NMTAVPSSAIRGLKQLQSLHLHKN-----------RIEQLDALN--------------------- 227

  Fly   335 LIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNR 399
                                   ||.                 ||:.||  ||||.|::|.|:.:
 Worm   228 -----------------------FLN-----------------LPVLNL--LNLAGNQIHELNRQ 250

  Fly   400 IFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVP-EAVQDLSMLKTLDLGENQ 463
            .|..:..|..|.|:.|.::.:.:..|:....|:.|||::|::..:| .::..|..|:.|.|..|:
 Worm   251 AFLNVPSLRYLYLSGNKITKLTAYQFQTFEQLEMLDLTNNEIGAIPANSLSGLKQLRQLYLAHNK 315

  Fly   464 ISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEA 528
            ||...:|.|.| :.:..|.|..|.:..:|.|:...||.|..::...|:|::|.|.||.....:..
 Worm   316 ISNISSNAFTN-SSIVVLVLSSNELKTLTAGIISGLPNLQQVSFRDNQIKTINRNAFYDAASLVM 379

  Fly   529 IRLDKNFLTDI-NGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQE 592
            :.|.||.||:| ...|....:||.::||||.|....|:...|.:..:.:..|.:....|.:.||:
 Worm   380 LDLAKNQLTEIAPTTFLAQLNLLLVDLSENKLPKTPYSAFNSRVGTVLLKENPLVCTENLHMLQQ 444

  Fly   593 EIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANV------ 651
            ...|...| |.:.|........|..:.:..:.:::| ..|....|   ::.::.::.||      
 Worm   445 GTGVYVRD-SPDIICGRKPTPKPEPVLVPIVTDSLI-STQRPALV---QIPKMQIHRNVHTTTGD 504

  Fly   652 -LSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMP 715
             ..:|...|.:...:...:.:|.   |.:.|..|          ..:||:          :.:.|
 Worm   505 QAPQIPSGAFQQIDLGKSRSLPR---GHSRFILD----------KPSTRE----------QSVEP 546

  Fly   716 HSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDAT-----WATNI 775
            .....|::|:...|..|                |..|...|.   |......:||     ..|:|
 Worm   547 TEELTPIQPIILPSRED----------------EIRQSSMEA---GTSQESVEATSQKIPSTTDI 592

  Fly   776 VDCGRQDLAALPNRIPQDVSDLYLD-GNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQL 839
            :|   :....||..:|      :|. |.|:.|.:....|...:...::......:.::.||..::
 Worm   593 ID---RPNVVLPFPVP------FLKRGPNLSESKKVESTDMPSTSQVFHTLPPSILIEPGSTPKV 648

  Fly   840 ------VNLRVLHLENNKLTALEGTE 859
                  .|::..|::...|.:....|
 Worm   649 AQPSTEANIKSEHIDEFALASSNSNE 674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 3/24 (13%)
leucine-rich repeat 92..115 CDD:275380 8/22 (36%)
LRR_8 115..181 CDD:290566 17/66 (26%)
leucine-rich repeat 116..146 CDD:275380 6/29 (21%)
leucine-rich repeat 147..170 CDD:275380 6/22 (27%)
leucine-rich repeat 171..201 CDD:275380 5/29 (17%)
LRR_RI 210..464 CDD:238064 56/255 (22%)
leucine-rich repeat 212..236 CDD:275380 4/23 (17%)
LRR_8 235..295 CDD:290566 17/60 (28%)
leucine-rich repeat 237..260 CDD:275380 4/23 (17%)
leucine-rich repeat 261..284 CDD:275380 6/22 (27%)
LRR_8 283..345 CDD:290566 11/61 (18%)
leucine-rich repeat 285..308 CDD:275380 6/22 (27%)
leucine-rich repeat 309..334 CDD:275380 2/24 (8%)
LRR_8 334..393 CDD:290566 11/58 (19%)
leucine-rich repeat 335..358 CDD:275380 0/22 (0%)
leucine-rich repeat 359..382 CDD:275380 3/22 (14%)
LRR_8 382..441 CDD:290566 20/58 (34%)
leucine-rich repeat 383..406 CDD:275380 9/22 (41%)
leucine-rich repeat 407..430 CDD:275380 5/22 (23%)
LRR_8 431..488 CDD:290566 19/57 (33%)
leucine-rich repeat 431..451 CDD:275380 6/20 (30%)
leucine-rich repeat 454..477 CDD:275380 9/22 (41%)
LRR_8 477..559 CDD:290566 27/82 (33%)
leucine-rich repeat 478..499 CDD:275380 5/20 (25%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 7/22 (32%)
leucine-rich repeat 590..617 CDD:275380 7/26 (27%)
leucine-rich repeat 618..641 CDD:275380 3/22 (14%)
leucine-rich repeat 642..689 CDD:275380 8/53 (15%)
LRRCT 679..736 CDD:214507 9/56 (16%)
leucine-rich repeat 775..796 CDD:275380 5/20 (25%)
LRR_8 797..852 CDD:290566 9/61 (15%)
leucine-rich repeat 797..817 CDD:275380 5/20 (25%)
leucine-rich repeat 818..841 CDD:275380 2/28 (7%)
LRR_8 841..900 CDD:290566 4/19 (21%)
leucine-rich repeat 842..865 CDD:275380 3/18 (17%)
LRR_4 866..907 CDD:289563
leucine-rich repeat 866..889 CDD:275380
leucine-rich repeat 890..911 CDD:275380
TIR 1045..1183 CDD:214587
let-4NP_510425.2 leucine-rich repeat 66..86 CDD:275380 7/19 (37%)
LRR_RI <71..275 CDD:238064 69/326 (21%)
LRR_8 88..146 CDD:290566 17/64 (27%)
leucine-rich repeat 88..111 CDD:275380 6/29 (21%)
leucine-rich repeat 112..135 CDD:275380 6/22 (27%)
leucine-rich repeat 136..160 CDD:275380 9/64 (14%)
LRR_8 156..220 CDD:290566 19/80 (24%)
leucine-rich repeat 161..184 CDD:275380 4/22 (18%)
leucine-rich repeat 186..209 CDD:275380 6/22 (27%)
leucine-rich repeat 210..257 CDD:275380 24/120 (20%)
LRR_RI <250..411 CDD:238064 49/161 (30%)
LRR_8 256..316 CDD:290566 16/59 (27%)
leucine-rich repeat 258..281 CDD:275380 5/22 (23%)
leucine-rich repeat 282..305 CDD:275380 7/22 (32%)
leucine-rich repeat 306..328 CDD:275380 9/22 (41%)
LRR_8 327..387 CDD:290566 17/59 (29%)
leucine-rich repeat 329..350 CDD:275380 5/20 (25%)
leucine-rich repeat 353..400 CDD:275380 14/46 (30%)
leucine-rich repeat 356..376 CDD:275380 6/19 (32%)
leucine-rich repeat 401..419 CDD:275380 8/17 (47%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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