DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and tol-1

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001020983.1 Gene:tol-1 / 171635 WormBaseID:WBGene00006593 Length:1221 Species:Caenorhabditis elegans


Alignment Length:1204 Identity:301/1204 - (25%)
Similarity:524/1204 - (43%) Gaps:191/1204 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 FRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELSEL 150
            |:.|..|..|||..|:........||.|.:|:||.|:..:..   ..:.|:.......|..|.:.
 Worm    90 FKSLTALHHLRIVGCETTHFSVKLFEDLAALRRLELDQISTA---STSFEMTEDVLMPLARLEKF 151

  Fly   151 HLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTL 215
            .|..:...:||:.:.||:|.||:||::.|.:.|..    .|:.|.             ..:|..:
 Worm   152 SLTRSRNIELPQRLLCSLPHLQVLNISSNELPSLR----REESCV-------------AQQLLIV 199

  Fly   216 DVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFA 280
            |:|.|.|                      .||...    |.|:.::|.::::||.:..|  :...
 Worm   200 DLSRNRL----------------------TNIEQF----LRGIPAIRQISVAYNSIAEL--DLSL 236

  Fly   281 GNKELRELHLQGN---DLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSN 342
            ....|::|..:.|   ||..||..::|       ::|:||.|  ..|.::. |.|..|:.||:|.
 Worm   237 ATPFLQQLDAEANRIVDLTSLPGTVVH-------VNLAGNAL--KRVPDAV-AELASLVALNVSR 291

  Fly   343 NALTRIGSKTFK--ELYFLQI----------------------LDMRNNSIGHIEEGAFLPLYNL 383
            |.:....|..|.  ||..|..                      |.:.:|||..:..|......||
 Worm   292 NEIEAGNSSVFSSPELEMLDASYNKLDSLPVEWLQKCEKRIAHLHLEHNSIEQLTGGVLANATNL 356

  Fly   384 HTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAV 448
            .||:|:.|:|....:.:......:..|.|:||.:.::|..:..... |:.||||.|:|||||.|:
 Worm   357 QTLDLSSNQLRVFRDEVLPENSKIGNLRLSNNSLELLEPSSLSGLK-LESLDLSHNKLTEVPAAI 420

  Fly   449 QDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQ 513
            ..:..||.:||..|:|::........:.||..:.|.:|::.:|...:|.|...|..|:::.|.|.
 Worm   421 GKVEQLKKVDLSHNRIAKVYQYVLNKIKQLHTVDLSNNQLQSIGPYIFSDSSELHSLDVSNNEIS 485

  Fly   514 SIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHG 578
            .:.:.||.:..::..|.:..|.:..::......:.|..|::|.|.::...::.:|.||:.|:...
 Worm   486 LLFKDAFARCPKLRKISMKMNKIKSLDEGLTEASGLRRLDVSHNEILVLKWSALPENLEILNADN 550

  Fly   579 NYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLA 643
            |.|..|...........:.::..|:|.||.:.|..:|||:|.|.::||.:.::.......|::|.
 Worm   551 NDINLLTAASMSPSTANLKSVSLSNNGITIMNADQIPNSLESLDVSNNRLAKLGKTALAAKSQLR 615

  Fly   644 RVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWL-------QRINNLTTRQH 701
            |::|..|:|:.::..:::|  |.|..|: :..:..||..|||.|.|:       ..|.:..|...
 Worm   616 RLNLKGNLLTVVATESMKV--VEAVHPL-KVEISENPLICDCQMGWMIGGAKPKVLIQDSETASC 677

  Fly   702 PHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCF 766
            .|.||...|:             :.|||..|.:|.|:|.|.|.|.||:|..|:|:.:||.||.||
 Worm   678 SHAVDGHQIQ-------------IQSLSKKDLLCPYKSVCEPECICCQYGNCDCKSVCPANCRCF 729

  Fly   767 HDATWATNIVDC-GRQDLAALPNR------IPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLN 824
            .|..:..|||.| |...:  :|.|      :|...:::.|.|..:|:|......||..|:.|::|
 Worm   730 RDDQFNINIVRCHGNSSM--VPKREFVVSELPVSATEIILSGVTLPQLRTHSFIGRLRLQRLHIN 792

  Fly   825 ASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVS 889
            .:.|.::|..:...|..|:.|.|.:|.|.:|.|.||...|.:.:|:|:.|..:.:|...||.|.:
 Worm   793 GTGLRSIQPKAFHTLPALKTLDLSDNSLISLSGEEFLKCGEVSQLFLNGNRFSTLSRGIFEKLPN 857

  Fly   890 LEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAWSCRC-----QQL-------------RELAQFV 936
            |:.|.|.||.|..:|.:.:..:|..::|..|...|.|     |.|             ...|::.
 Worm   858 LKYLTLHNNSLEDIPQVLHSTALSKISLSSNPLRCDCSGGSQQHLHHRRDPKAHPFWEHNAAEWF 922

  Fly   937 SDNAMVVRDAHDIYCLD----AGIKRELELIG----NLANG----------PDCSDLLDASASNI 983
            |.:..:|.|...:.|.:    |.:..:..::.    |:.|.          .|.:..:....|:.
 Worm   923 SLHRHLVVDFPKVECWENVTKAFLTNDTTVLSAYPPNMGNDVFVMPIEEFLRDYNSTICVPFSSG 987

  Fly   984 SSSQDLAGGYRLPLLA-AVLVLIFLVVVLIIVFVFRESVRMWLFAHYGVRVCEPRFE-------- 1039
            ...||........::. ::.||:.::|:|.|.|: |:|       |..:.  :.|::        
 Worm   988 FFGQDPQNSILFVIITISIAVLLCVLVILAISFI-RKS-------HDAIN--QRRYKASSLNCST 1042

  Fly  1040 DAGK--------LYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHL-----Q 1091
            .||.        .|.|.:.:|:||.:.|...:...||.  ..::||:..||.|...|:|     :
 Worm  1043 SAGSSPLPVPLLSYHAFVSYSKKDEKMVIDQLCRPLED--EDYQLCLLHRDGPTYCSNLHAISDE 1105

  Fly  1092 LVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPY 1156
            |:....:|:.:|||||::.|..||..::.:.:.....:..|::::.:....|.|...| .||...
 Worm  1106 LIAQMDSSQCLILVLTKHFLENEWKTLQIKTSHQLFAKNRAKRVIAVLGDGVDANLLD-DELGQI 1169

  Fly  1157 LKSVPSNRLLTCDRYFWEKLRYAIPIELSPRGNN 1190
            |:.  ..|:......||..|..::|..|....|:
 Worm  1170 LRK--HTRIEMRSHLFWTLLHSSLPSRLPLPSNS 1201

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 2/4 (50%)
leucine-rich repeat 92..115 CDD:275380 8/22 (36%)
LRR_8 115..181 CDD:290566 18/65 (28%)
leucine-rich repeat 116..146 CDD:275380 6/29 (21%)
leucine-rich repeat 147..170 CDD:275380 6/22 (27%)
leucine-rich repeat 171..201 CDD:275380 8/29 (28%)
LRR_RI 210..464 CDD:238064 72/280 (26%)
leucine-rich repeat 212..236 CDD:275380 5/23 (22%)
LRR_8 235..295 CDD:290566 11/62 (18%)
leucine-rich repeat 237..260 CDD:275380 4/22 (18%)
leucine-rich repeat 261..284 CDD:275380 4/22 (18%)
LRR_8 283..345 CDD:290566 20/64 (31%)
leucine-rich repeat 285..308 CDD:275380 8/25 (32%)
leucine-rich repeat 309..334 CDD:275380 7/24 (29%)
LRR_8 334..393 CDD:290566 21/82 (26%)
leucine-rich repeat 335..358 CDD:275380 9/24 (38%)
leucine-rich repeat 359..382 CDD:275380 6/44 (14%)
LRR_8 382..441 CDD:290566 18/58 (31%)
leucine-rich repeat 383..406 CDD:275380 6/22 (27%)
leucine-rich repeat 407..430 CDD:275380 5/22 (23%)
LRR_8 431..488 CDD:290566 22/56 (39%)
leucine-rich repeat 431..451 CDD:275380 12/19 (63%)
leucine-rich repeat 454..477 CDD:275380 6/22 (27%)
LRR_8 477..559 CDD:290566 19/81 (23%)
leucine-rich repeat 478..499 CDD:275380 5/20 (25%)
leucine-rich repeat 502..525 CDD:275380 6/22 (27%)
leucine-rich repeat 526..548 CDD:275380 2/21 (10%)
leucine-rich repeat 590..617 CDD:275380 6/26 (23%)
leucine-rich repeat 618..641 CDD:275380 5/22 (23%)
leucine-rich repeat 642..689 CDD:275380 15/46 (33%)
LRRCT 679..736 CDD:214507 17/63 (27%)
leucine-rich repeat 775..796 CDD:275380 7/27 (26%)
LRR_8 797..852 CDD:290566 16/54 (30%)
leucine-rich repeat 797..817 CDD:275380 6/19 (32%)
leucine-rich repeat 818..841 CDD:275380 6/22 (27%)
LRR_8 841..900 CDD:290566 22/58 (38%)
leucine-rich repeat 842..865 CDD:275380 9/22 (41%)
LRR_4 866..907 CDD:289563 14/40 (35%)
leucine-rich repeat 866..889 CDD:275380 7/22 (32%)
leucine-rich repeat 890..911 CDD:275380 7/20 (35%)
TIR 1045..1183 CDD:214587 37/142 (26%)
tol-1NP_001020983.1 leucine-rich repeat 71..95 CDD:275380 2/4 (50%)
leucine-rich repeat 96..119 CDD:275380 8/22 (36%)
leucine-rich repeat 120..171 CDD:275380 12/53 (23%)
leucine-rich repeat 172..195 CDD:275380 8/39 (21%)
leucine-rich repeat 196..283 CDD:275380 28/124 (23%)
leucine-rich repeat 219..240 CDD:275378 4/22 (18%)
leucine-rich repeat 241..258 CDD:275378 5/16 (31%)
LRR 265..600 CDD:227223 90/338 (27%)
leucine-rich repeat 287..306 CDD:275380 6/18 (33%)
leucine-rich repeat 307..331 CDD:275380 2/23 (9%)
leucine-rich repeat 332..355 CDD:275380 5/22 (23%)
leucine-rich repeat 356..379 CDD:275380 6/22 (27%)
leucine-rich repeat 380..395 CDD:275380 4/14 (29%)
leucine-rich repeat 403..425 CDD:275380 12/21 (57%)
leucine-rich repeat 426..449 CDD:275380 6/22 (27%)
leucine-rich repeat 450..473 CDD:275380 6/22 (27%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..520 CDD:275380 2/21 (10%)
leucine-rich repeat 543..567 CDD:275380 5/23 (22%)
leucine-rich repeat 568..589 CDD:275380 6/20 (30%)
leucine-rich repeat 590..613 CDD:275380 5/22 (23%)
leucine-rich repeat 614..633 CDD:275380 5/18 (28%)
leucine-rich repeat 763..785 CDD:275378 6/21 (29%)
LRR_8 785..844 CDD:338972 19/58 (33%)
leucine-rich repeat 786..809 CDD:275378 6/22 (27%)
LRR_9 <806..>890 CDD:373143 28/83 (34%)
leucine-rich repeat 810..833 CDD:275378 9/22 (41%)
leucine-rich repeat 834..857 CDD:275378 7/22 (32%)
leucine-rich repeat 858..879 CDD:275378 7/20 (35%)
leucine-rich repeat 880..892 CDD:275378 3/11 (27%)
TIR_2 1056..1194 CDD:390066 37/142 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 132 1.000 Domainoid score I3176
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 370 1.000 Inparanoid score I1230
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG28754
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 1 1.000 - - FOG0006722
OrthoInspector 1 1.000 - - otm14097
orthoMCL 1 0.900 - - OOG6_104126
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.740

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