DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Tlr8

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_573475.2 Gene:Tlr8 / 170744 MGIID:2176887 Length:1032 Species:Mus musculus


Alignment Length:1330 Identity:293/1330 - (22%)
Similarity:465/1330 - (34%) Gaps:442/1330 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPATSSIITIIAVAACLLLLVADAHA-QQQCNWQYGLTTMDIR--------CSVRALESGTGTPL 56
            ||..|.|:|      |..||.:...| ..:.|:.......:||        |:.|.|.       
Mouse     4 MPPQSWILT------CFCLLSSGTSAIFHKANYSRSYPCDEIRHNSLVIAECNHRQLH------- 55

  Fly    57 DLQVAEAAGR----LDLQCSQELLHASELAPGLFRQLQKLSELRIDACKLQRVP------PNAFE 111
              :|.:..|:    :||. ...:.|.::.:   |::||.|:::.::....|:.|      .|..|
Mouse    56 --EVPQTIGKYVTNIDLS-DNAITHITKES---FQKLQNLTKIDLNHNAKQQHPNENKNGMNITE 114

  Fly   112 G-LMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMP-SLQLL 174
            | |:||:.||:                            |.|.||.:..:|.|    :| ||:.|
Mouse   115 GALLSLRNLTV----------------------------LLLEDNQLYTIPAG----LPESLKEL 147

  Fly   175 NLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQT 239
            :|.||.|                                 ..|:.|      :.:|   ||.|:.
Mouse   148 SLIQNNI---------------------------------FQVTKN------NTFG---LRNLER 170

  Fly   240 LSL------QHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYEL 298
            |.|      :.|....:...|...|..|:||::|:|:|..:|.:.   ...||:|.|....:..:
Mouse   171 LYLGWNCYFKCNQTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPKL---PSSLRKLFLSNAKIMNI 232

  Fly   299 PKGLLHRLEQLLVLDLSGN---------------QLTSHHVDNSTFAGLIRLIVLNLSNNALTRI 348
            .:.....||.|.:||||||               :.:|.|:....|..|.:|:.||||:.:|..|
Mouse   233 TQEDFKGLENLTLLDLSGNCPRCYNAPFPCTPCKENSSIHIHPLAFQSLTQLLYLNLSSTSLRTI 297

  Fly   349 GSKTFKELYFLQILDMR-NNSIGHIEEGAFL-PLYNLHTLNLAENRLHTLDNRIFNGLY--VLTK 409
            .|..|:.|..|:.|.:. |..:..|..|||| .|.:|..|:|:           ||..|  .|..
Mouse   298 PSTWFENLSNLKELHLEFNYLVQEIASGAFLTKLPSLQILDLS-----------FNFQYKEYLQF 351

  Fly   410 LTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVP----EAVQDLSMLKTLDLGENQISEFKNN 470
            :.:::|         |.....||:|.|......|:.    |.:|.|..|.|::||.|.|.:....
Mouse   352 INISSN---------FSKLRSLKKLHLRGYVFRELKKKHFEHLQSLPNLATINLGINFIEKIDFK 407

  Fly   471 TFRNLNQLTGLRLIDNRIGNIT--------------------------VGMFQDLPRL------- 502
            .|:|.::|..:.|..|||.::.                          |..:.....|       
Mouse   408 AFQNFSKLDVIYLSGNRIASVLDGTDYSSWRNRLRKPLSTDDDEFDPHVNFYHSTKPLIKPQCTA 472

  Fly   503 --SVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDI-NGI-FATLASLLWLNLSENHLVWFD 563
              ..|:|:.|.|..|.:..|:...:|..:.|..|..|.: ||. |:::..:.:|:|:.|.|.:.|
Mouse   473 YGKALDLSLNNIFIIGKSQFEGFQDIACLNLSFNANTQVFNGTEFSSMPHIKYLDLTNNRLDFDD 537

  Fly   564 -YAFIP-SNLKWLDIHGN--YIEALGNYYKL---QEEIRVTTLDASHNRITEIGAMSVPNSI--- 618
             .||.. .:|:.||:..|  |....|..::|   |..|.:..|:.|||.|..:...|...||   
Mouse   538 NNAFSDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLINLRVLNLSHNGIYTLTEESELKSISLK 602

  Fly   619 ELLFINNNIIGQIQAN------TFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLG 677
            ||:|..|.:.....||      .|.....|.|:||..|.|.:|...|....|.|.:    |..:.
Mouse   603 ELVFSGNRLDRLWNANDGKYWSIFKSLQNLIRLDLSYNNLQQIPNGAFLNLPQSLQ----ELLIS 663

  Fly   678 GNPFECDCSMEWLQRINNLTTRQH-PHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHC 741
            ||..          |..|.|..|: ||:                                     
Mouse   664 GNKL----------RFFNWTLLQYFPHL------------------------------------- 681

  Fly   742 PPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPN---RIPQDVSDLYLDGNN 803
                                            :::|..|.:|..|||   :....:..|.|..|:
Mouse   682 --------------------------------HLLDLSRNELYFLPNCLSKFAHSLETLLLSHNH 714

  Fly   804 MPELEVGHLTGRRNLRALYLNASNLMTLQNGSL--AQLVNLRVLHLENNKL-TALEGTEFRSLGL 865
            ...|..|.|:..|||..|.|:.:.:..:...||  ....||.:|.|..|.. ...:.::|||   
Mouse   715 FSHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGNYFDCTCDISDFRS--- 776

  Fly   866 LRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAWSCRCQQLR 930
                :|..|:     |.|...||         |.:.|.|..|...|:..|               
Mouse   777 ----WLDENL-----NITIPKLV---------NVICSNPGDQKSKSIMSL--------------- 808

  Fly   931 ELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRL 995
            :|...|||..                                                       
Mouse   809 DLTTCVSDTT------------------------------------------------------- 818

  Fly   996 PLLAAVL-VLIFLVVVLIIVFVFRESV---RMWLFAHYGVRVCEPRFE------DAGKLYDAIIL 1050
               |||| .|.||...::::......:   .:|...|    :|..:.:      .:...|||.|.
Mouse   819 ---AAVLFFLTFLTTSMVMLAALVHHLFYWDVWFIYH----MCSAKLKGYRTSSTSQTFYDAYIS 876

  Fly  1051 HSEKD---YEFVCRNIAAELEHGR-PPFRLCIQQRDLPPQASHL-QLVEGARASRKIILVLTRNL 1110
            :..||   .::|...:...||... ....||:::||..|....: .|::....|:|.|.|||:. 
Mouse   877 YDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKK- 940

  Fly  1111 LATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYLK--------SV---PSNR 1164
            .|..||   |:.||:.:|:.|..:.:   :..:....|.|.:.|.||:        |:   |:|.
Mouse   941 YAKSWN---FKTAFYLALQRLMDENM---DVIIFILLEPVLQYSQYLRLRQRICKSSILQWPNNP 999

  Fly  1165 LLTCDRYFWEKLRYAIPIELSPRGNNYTLD 1194
              ..:..||:.|:..:..|...|.::..:|
Mouse  1000 --KAENLFWQSLKNVVLTENDSRYDDLYID 1027

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 5/28 (18%)
leucine-rich repeat 92..115 CDD:275380 7/29 (24%)
LRR_8 115..181 CDD:404697 17/66 (26%)
leucine-rich repeat 116..146 CDD:275380 3/29 (10%)
leucine-rich repeat 147..170 CDD:275380 7/23 (30%)
leucine-rich repeat 171..201 CDD:275380 6/29 (21%)
LRR 210..592 CDD:443914 113/454 (25%)
leucine-rich repeat 212..236 CDD:275380 4/23 (17%)
leucine-rich repeat 237..260 CDD:275380 6/28 (21%)
leucine-rich repeat 261..284 CDD:275380 7/22 (32%)
leucine-rich repeat 285..308 CDD:275380 5/22 (23%)
leucine-rich repeat 309..334 CDD:275380 11/39 (28%)
leucine-rich repeat 335..358 CDD:275380 10/22 (45%)
leucine-rich repeat 359..382 CDD:275380 9/24 (38%)
leucine-rich repeat 383..406 CDD:275380 6/24 (25%)
leucine-rich repeat 407..430 CDD:275380 3/22 (14%)
leucine-rich repeat 431..451 CDD:275380 7/23 (30%)
leucine-rich repeat 454..477 CDD:275380 8/22 (36%)
leucine-rich repeat 478..499 CDD:275380 6/46 (13%)
leucine-rich repeat 502..525 CDD:275380 7/31 (23%)
leucine-rich repeat 526..548 CDD:275380 7/23 (30%)
leucine-rich repeat 590..617 CDD:275380 9/29 (31%)
leucine-rich repeat 618..641 CDD:275380 8/31 (26%)
leucine-rich repeat 642..689 CDD:275380 13/46 (28%)
LRRCT 679..736 CDD:214507 7/57 (12%)
LRR <775..>920 CDD:443914 39/150 (26%)
leucine-rich repeat 775..796 CDD:275380 6/23 (26%)
leucine-rich repeat 797..817 CDD:275380 6/19 (32%)
leucine-rich repeat 818..841 CDD:275380 5/24 (21%)
leucine-rich repeat 842..865 CDD:275380 7/23 (30%)
leucine-rich repeat 866..889 CDD:275380 5/22 (23%)
leucine-rich repeat 890..911 CDD:275380 4/20 (20%)
TIR 1045..1183 CDD:214587 40/153 (26%)
Tlr8NP_573475.2 LRR 1 41..61 4/28 (14%)
LRR 2 62..85 5/26 (19%)
leucine-rich repeat 65..88 CDD:275380 5/26 (19%)
LRR 66..484 CDD:443914 120/518 (23%)
LRR 3 87..109 4/21 (19%)
leucine-rich repeat 89..122 CDD:275380 9/32 (28%)
LRR 4 120..143 10/54 (19%)
leucine-rich repeat 123..143 CDD:275380 9/51 (18%)
leucine-rich repeat 144..167 CDD:275380 10/64 (16%)
LRR 5 145..165 8/61 (13%)
LRR 6 166..194 6/27 (22%)
leucine-rich repeat 168..197 CDD:275380 6/28 (21%)
LRR 7 195..218 8/25 (32%)
leucine-rich repeat 198..218 CDD:275380 7/22 (32%)
leucine-rich repeat 219..242 CDD:275380 5/22 (23%)
LRR 8 220..239 3/18 (17%)
LRR 9 240..267 9/26 (35%)
leucine-rich repeat 243..283 CDD:275380 11/39 (28%)
LRR 10 281..304 10/22 (45%)
leucine-rich repeat 284..307 CDD:275380 10/22 (45%)
LRR 11 306..329 7/22 (32%)
leucine-rich repeat 308..327 CDD:275380 5/18 (28%)
LRR 12 331..360 10/48 (21%)
leucine-rich repeat 334..363 CDD:275380 9/48 (19%)
LRR 13 361..384 5/22 (23%)
leucine-rich repeat 364..390 CDD:275380 8/25 (32%)
LRR 14 388..411 8/22 (36%)
leucine-rich repeat 391..414 CDD:275380 8/22 (36%)
LRR 15 413..436 5/22 (23%)
leucine-rich repeat 465..497 CDD:275380 7/31 (23%)
LRR 16 471..494 6/22 (27%)
LRR_8 501..555 CDD:404697 16/53 (30%)
leucine-rich repeat 501..522 CDD:275380 6/20 (30%)
LRR 17 520..543 7/22 (32%)
leucine-rich repeat 523..546 CDD:275380 7/22 (32%)
LRR <532..791 CDD:443914 80/362 (22%)
LRR 18 545..572 7/26 (27%)
leucine-rich repeat 547..576 CDD:275380 8/28 (29%)
LRR 19 574..598 7/23 (30%)
leucine-rich repeat 577..600 CDD:275380 7/22 (32%)
LRR 20 600..621 6/20 (30%)
leucine-rich repeat 601..631 CDD:275380 7/29 (24%)
LRR 21 629..652 8/22 (36%)
leucine-rich repeat 632..656 CDD:275380 9/23 (39%)
LRR 22 654..677 8/36 (22%)
leucine-rich repeat 657..680 CDD:275380 7/36 (19%)
LRR 23 678..701 8/91 (9%)
leucine-rich repeat 681..704 CDD:275380 6/91 (7%)
LRR 24 702..725 6/22 (27%)
leucine-rich repeat 705..728 CDD:275380 6/22 (27%)
LRR 25 727..749 7/21 (33%)
leucine-rich repeat 729..748 CDD:275380 4/18 (22%)
LRR 26 752..776 6/23 (26%)
TIR 871..1007 CDD:214587 38/144 (26%)

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