DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and Tlr7

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001277687.1 Gene:Tlr7 / 170743 MGIID:2176882 Length:1053 Species:Mus musculus


Alignment Length:1255 Identity:276/1255 - (21%)
Similarity:481/1255 - (38%) Gaps:345/1255 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PLDLQVAEAAGRLDLQCSQELLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRL 119
            |.:::|......:.:.|:.:  |.:|:..|:......|: |.|:  .:..:.|::|..|..|:.:
Mouse    38 PCEVKVNIPEAHVIVDCTDK--HLTEIPEGIPTNTTNLT-LTIN--HIPSISPDSFRRLNHLEEI 97

  Fly   120 TLESHNAVWGP----------GKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMP-SLQL 173
            .|.. |.|  |          .|.|::...||.||.:|..|:|..|.:.::|:    .:| ||.|
Mouse    98 DLRC-NCV--PVLLGSKANVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIPQ----DLPSSLHL 155

  Fly   174 LNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQ 238
            |:|..|.|.|               ::..|                           .:.|..::
Mouse   156 LSLEANNIFS---------------ITKEN---------------------------LTELVNIE 178

  Fly   239 TLSLQHN-------NIS-TLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDL 295
            ||.|..|       |:| ::..:|...:.:|:||::..|::.::|:..   ...|.||:|..|.:
Mouse   179 TLYLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTL---PPNLLELYLYNNII 240

  Fly   296 YELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQ 360
            .::.:...:.|.:|.|||||||....::|...         .....||:..:|....|..|..|:
Mouse   241 KKIQENDFNNLNELQVLDLSGNCPRCYNVPYP---------CTPCENNSPLQIHDNAFNSLTELK 296

  Fly   361 ILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAF 425
            :|.:.:||:.|:....|..:.||..|:|::|.|..                      .|.|::..
Mouse   297 VLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAR----------------------EIEEAKFL 339

  Fly   426 RNCSDLKELDLSSNQLTEV-------PEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRL 483
            ....:|.|||.|.|...:|       |.::..|..||.|.:......|.||::...|::      
Mouse   340 HFLPNLVELDFSFNYELQVYHASITLPHSLSSLENLKILRVKGYVFKELKNSSLSVLHK------ 398

  Fly   484 IDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLAS 548
                           ||||.||:|..|.|:                      :.|:| ||....:
Mouse   399 ---------------LPRLEVLDLGTNFIK----------------------IADLN-IFKHFEN 425

  Fly   549 LLWLNLSENHL----VWFDYAFIPSNLKWLDIHG-NYIEALGNYYKLQEEIRV------------ 596
            |..::||.|.:    ...:..|.|:....:|.|| ..:||| :|::..|..|.            
Mouse   426 LKLIDLSVNKISPSEESREVGFCPNAQTSVDRHGPQVLEAL-HYFRYDEYARSCRFKNKEPPSFL 489

  Fly   597 ----------TTLDASHNRITEIGAMSVP--NSIELLFINNNIIGQ---------IQANTFVDKT 640
                      .|||.|.|.|..|......  :.::.|.::.|.|||         ::...::|.:
Mouse   490 PLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFS 554

  Fly   641 RLARVD-LYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHV 704
            . .|:| ||:....:  |.:|.|..:|:         ..:.|:.    |.:..:.|.|.:     
Mouse   555 N-NRLDLLYSTAFEE--LQSLEVLDLSS---------NSHYFQA----EGITHMLNFTKK----- 598

  Fly   705 VDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHD- 768
              |..::.||.:...      .|.|||..:   ||   .:....|:.....:|:.....:.:.| 
Mouse   599 --LRLLDKLMMNDND------ISTSASRTM---ES---DSLRILEFRGNHLDVLWRAGDNRYLDF 649

  Fly   769 --ATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTL 831
              ..:...::|..|..|    |.:|.:|.:      .||.          ||:.|.|..:.|.:.
Mouse   650 FKNLFNLEVLDISRNSL----NSLPPEVFE------GMPP----------NLKNLSLAKNGLKSF 694

  Fly   832 QNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLD 896
            ....|..|.:|.:|.|.:|:||.:..........|..|.|.:|.:..::....|..:.|..|.:.
Mouse   695 FWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDIS 759

  Fly   897 NNRL-----SSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGI 956
            :|::     :|.|. ...::|:.|.|..|.:.|.|..:..:......:..:...|.|:.|:..|.
Mouse   760 SNKIQVIQKTSFPE-NVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCVGPGA 823

  Fly   957 KRELELIG------NLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVF 1015
            .:...:|.      .|    |.::|:..|.| |||                  ::||:||:....
Mouse   824 HKGQSVISLDLYTCEL----DLTNLILFSVS-ISS------------------VLFLMVVMTTSH 865

  Fly  1016 VFRESVRMWLFAHY------GVRVCEPRFEDAGKLYDAIILHSEKD---YEFVCRNIAAELEHGR 1071
            :|...  ||...::      |.:    ..:.....|||.|::..|:   .|:|.:.:.|:||..|
Mouse   866 LFFWD--MWYIYYFWKAKIKGYQ----HLQSMESCYDAFIVYDTKNSAVTEWVLQELVAKLEDPR 924

  Fly  1072 PP-FRLCIQQRD-LPPQASHLQLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHES-LRGLAQ 1133
            .. |.||:::|| ||.|.....|.:..:.|:|.:.|:|:....||    .|:.||:.| .|.|.:
Mouse   925 EKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTE----SFKMAFYLSHQRLLDE 985

  Fly  1134 KLVIIEETSVSAEAEDVAELSPYLK--------SV---PSNRLLTCDRYFWEKLRYAIPIELSPR 1187
            |:.:|    :....|...:.|.:|:        ||   |:|.  ....|||:.|:.|:       
Mouse   986 KVDVI----ILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANP--QAHPYFWQCLKNAL------- 1037

  Fly  1188 GNNYTLDHH----ERFKQPV 1203
                |.|:|    :.||:.|
Mouse  1038 ----TTDNHVAYSQMFKETV 1053

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 4/24 (17%)
leucine-rich repeat 92..115 CDD:275380 6/22 (27%)
LRR_8 115..181 CDD:290566 23/76 (30%)
leucine-rich repeat 116..146 CDD:275380 11/39 (28%)
leucine-rich repeat 147..170 CDD:275380 6/23 (26%)
leucine-rich repeat 171..201 CDD:275380 7/29 (24%)
LRR_RI 210..464 CDD:238064 59/268 (22%)
leucine-rich repeat 212..236 CDD:275380 1/23 (4%)
LRR_8 235..295 CDD:290566 17/67 (25%)
leucine-rich repeat 237..260 CDD:275380 7/30 (23%)
leucine-rich repeat 261..284 CDD:275380 5/22 (23%)
LRR_8 283..345 CDD:290566 17/61 (28%)
leucine-rich repeat 285..308 CDD:275380 6/22 (27%)
leucine-rich repeat 309..334 CDD:275380 9/24 (38%)
LRR_8 334..393 CDD:290566 16/58 (28%)
leucine-rich repeat 335..358 CDD:275380 5/22 (23%)
leucine-rich repeat 359..382 CDD:275380 6/22 (27%)
LRR_8 382..441 CDD:290566 14/58 (24%)
leucine-rich repeat 383..406 CDD:275380 5/22 (23%)
leucine-rich repeat 407..430 CDD:275380 2/22 (9%)
LRR_8 431..488 CDD:290566 16/63 (25%)
leucine-rich repeat 431..451 CDD:275380 8/26 (31%)
leucine-rich repeat 454..477 CDD:275380 7/22 (32%)
LRR_8 477..559 CDD:290566 17/81 (21%)
leucine-rich repeat 478..499 CDD:275380 0/20 (0%)
leucine-rich repeat 502..525 CDD:275380 6/22 (27%)
leucine-rich repeat 526..548 CDD:275380 4/21 (19%)
leucine-rich repeat 590..617 CDD:275380 9/50 (18%)
leucine-rich repeat 618..641 CDD:275380 6/31 (19%)
leucine-rich repeat 642..689 CDD:275380 9/47 (19%)
LRRCT 679..736 CDD:214507 11/56 (20%)
leucine-rich repeat 775..796 CDD:275380 6/20 (30%)
LRR_8 797..852 CDD:290566 13/54 (24%)
leucine-rich repeat 797..817 CDD:275380 2/19 (11%)
leucine-rich repeat 818..841 CDD:275380 6/22 (27%)
LRR_8 841..900 CDD:290566 14/58 (24%)
leucine-rich repeat 842..865 CDD:275380 6/22 (27%)
LRR_4 866..907 CDD:289563 10/45 (22%)
leucine-rich repeat 866..889 CDD:275380 5/22 (23%)
leucine-rich repeat 890..911 CDD:275380 5/25 (20%)
TIR 1045..1183 CDD:214587 46/154 (30%)
Tlr7NP_001277687.1 PRK15370 <35..>246 CDD:185268 56/264 (21%)
leucine-rich repeat 51..72 CDD:275380 4/22 (18%)
leucine-rich repeat 73..93 CDD:275380 6/22 (27%)
leucine-rich repeat 94..131 CDD:275380 11/39 (28%)
leucine-rich repeat 132..155 CDD:275380 8/26 (31%)
PLN00113 177..>789 CDD:215061 162/746 (22%)
leucine-rich repeat 177..208 CDD:275380 7/30 (23%)
leucine-rich repeat 209..229 CDD:275380 5/22 (23%)
leucine-rich repeat 230..253 CDD:275380 6/22 (27%)
leucine-rich repeat 254..294 CDD:275380 14/48 (29%)
leucine-rich repeat 295..318 CDD:275380 6/22 (27%)
leucine-rich repeat 319..344 CDD:275380 7/46 (15%)
leucine-rich repeat 345..401 CDD:275380 17/76 (22%)
leucine-rich repeat 402..425 CDD:275380 10/45 (22%)
leucine-rich repeat 500..522 CDD:275380 7/21 (33%)
leucine-rich repeat 523..547 CDD:275380 5/23 (22%)
leucine-rich repeat 548..571 CDD:275380 6/25 (24%)
leucine-rich repeat 572..601 CDD:275380 8/48 (17%)
leucine-rich repeat 602..624 CDD:275380 8/33 (24%)
leucine-rich repeat 625..655 CDD:275380 3/29 (10%)
leucine-rich repeat 656..680 CDD:275380 8/43 (19%)
leucine-rich repeat 681..704 CDD:275380 6/22 (27%)
leucine-rich repeat 705..728 CDD:275380 6/22 (27%)
leucine-rich repeat 753..778 CDD:275380 5/25 (20%)
PCC 757..>841 CDD:188093 15/88 (17%)
TIR 894..1039 CDD:214587 46/165 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.780

Return to query results.
Submit another query.