DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and CHADL

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	XP_011528235.1	Gene:	CHADL / 150356	HGNCID:	25165	Length:	830	Species:	Homo sapiens

Alignment Length:	929	Identity:	215/929 - (23%)
Similarity:	317/929 - (34%)	Gaps:	278/929 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 CKLQRVPPNAFEGLMSLKR--LTLESHNAVWGPGKTLELHGQSFQGLKELSELHLGD-----NNI 157
            |..||:..:.:||....:|  .|.:|..:.|.|     |.....||.:...:...|.     |:.
Human     3 CVFQRLGSSLWEGSPHGRREPRTADSRASCWCP-----LPVGLAQGFRPGPQSSAGAGRRPCNSS 62

  Fly   158 RQLPEGVWCSMP-----SLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANG--AVSGGS----- 210
            |       ||.|     |.|         ....:|.:|....:.||||...|  ||.|||
Human    63 R-------CSRPPPAPSSPQ---------PGEAWLAWSADNASHSALSQLPGLRAVEGGSCQAGT 111

  Fly   211 -------------------ELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALA 256
                               ..|.||:..|.|:.:|.| ....:..|..|.|:|..:..:|..|..
Human   112 ACPCAAPPGWTSSSRRHGGLTQRLDLQGNLLKVIPAA-AFQGVPHLTHLDLRHCEVELVAEGAFR 175

  Fly   257 GLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTS 321
            ||..|.:||::.|||..||.||..|...||.|.|:||.|.||..|....|..|..|:|:.|.|.
Human   176 GLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALV- 239

  Fly   322 HHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTL 386
             ::....|.||:|:..|.||:|||:.:..:....|..|:.|.:.:|.:..:..........|..|
Human   240 -YLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARL 303

  Fly   387 NLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDL 451
            .|..|.|..........|..|.:|.|:...:..:..:||.:|..|..|||..|||..:| .:|..
Human   304 ELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP-PLQGP 367

  Fly   452 SMLKTLDLGENQI-------------------SEFKNNTFRNL--NQLTGLRLIDNRIGNITVGM 495
            ..|:.|.|..|.:                   |:......|.|  ..|..||..|.|........
Human   368 GQLRRLRLQGNPLWCGCQARPLLEWLARARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQE 432

  Fly   496 FQDL----------------------------PRLSVLNLAKNR--------IQSIERGAFDKNT 524
            .::|                            ||..|. :.::|        :|::.|| |..:|
Human   433 EEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACVC-VPESRHSSCEGCGLQAVPRG-FPSDT 495

  Fly   525 EIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYK 589
            ::                         |:|..||......|..|              .||:
Human   496 QL-------------------------LDLRRNHFPSVPRAAFP--------------GLGH--- 518

  Fly   590 LQEEIRVTTLDASHNRITEI--GAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVL 652
                  :.:|...|..|.|:  ||::....:..|::::|.:..:.|.......||..:.|..|..
Human   519 ------LVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRF 577

  Fly   653 SKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHS 717
            .::...|||..|                     |:..|...:|...|..|.  |||
Human   578 LQVPGAALRALP---------------------SLFSLHLQDNAVDRLAPG--DLG--------- 610

  Fly   718 RSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQD 782
            |:..||                                               |
Human   611 RTRALR-----------------------------------------------W----------- 617

  Fly   783 LAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHL 847
                          :||.||.:.|:.:|.|...|.|..|:|:.:.|..:..|:|..|..|..|.|
Human   618 --------------VYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQL 668

  Fly   848 ENNKLTALEGTEFRSLG-LLRELYLHNNMLTHISNATFEPL-VSLEVLRLDNNRLSSLPHLQYRH 910
            ..|.|.||....|:.:| .|:.|:|:::.|..|....|..| ..|:.|.|..|:|.:||.|....
Human   669 SGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLS 733

  Fly   911 SLQGLTLGRNAWSCRCQQL 929
            .|:.:.|..|.:.|.||.|
Human   734 QLELIDLSSNPFHCDCQLL 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380	5/14 (36%)
		LRR_8	115..181	CDD:290566	16/77 (21%)
		leucine-rich repeat	116..146	CDD:275380	8/31 (26%)
		leucine-rich repeat	147..170	CDD:275380	6/32 (19%)
		leucine-rich repeat	171..201	CDD:275380	6/29 (21%)
		LRR_RI	210..464	CDD:238064	82/277 (30%)
		leucine-rich repeat	212..236	CDD:275380	7/23 (30%)
		LRR_8	235..295	CDD:290566	25/59 (42%)
		leucine-rich repeat	237..260	CDD:275380	8/22 (36%)
		leucine-rich repeat	261..284	CDD:275380	11/22 (50%)
		LRR_8	283..345	CDD:290566	24/61 (39%)
		leucine-rich repeat	285..308	CDD:275380	11/22 (50%)
		leucine-rich repeat	309..334	CDD:275380	8/24 (33%)
		LRR_8	334..393	CDD:290566	15/58 (26%)
		leucine-rich repeat	335..358	CDD:275380	7/22 (32%)
		leucine-rich repeat	359..382	CDD:275380	3/22 (14%)
		LRR_8	382..441	CDD:290566	17/58 (29%)
		leucine-rich repeat	383..406	CDD:275380	6/22 (27%)
		leucine-rich repeat	407..430	CDD:275380	6/22 (27%)
		LRR_8	431..488	CDD:290566	20/77 (26%)
		leucine-rich repeat	431..451	CDD:275380	9/19 (47%)
		leucine-rich repeat	454..477	CDD:275380	7/43 (16%)
		LRR_8	477..559	CDD:290566	18/117 (15%)
		leucine-rich repeat	478..499	CDD:275380	5/20 (25%)
		leucine-rich repeat	502..525	CDD:275380	6/30 (20%)
		leucine-rich repeat	526..548	CDD:275380	0/21 (0%)
		leucine-rich repeat	590..617	CDD:275380	6/28 (21%)
		leucine-rich repeat	618..641	CDD:275380	3/22 (14%)
		leucine-rich repeat	642..689	CDD:275380	8/46 (17%)
		LRRCT	679..736	CDD:214507	11/56 (20%)
		leucine-rich repeat	775..796	CDD:275380	0/20 (0%)
		LRR_8	797..852	CDD:290566	19/54 (35%)
		leucine-rich repeat	797..817	CDD:275380	7/19 (37%)
		leucine-rich repeat	818..841	CDD:275380	7/22 (32%)
		LRR_8	841..900	CDD:290566	20/60 (33%)
		leucine-rich repeat	842..865	CDD:275380	9/23 (39%)
		LRR_4	866..907	CDD:289563	14/41 (34%)
		leucine-rich repeat	866..889	CDD:275380	7/23 (30%)
		leucine-rich repeat	890..911	CDD:275380	8/20 (40%)
		TIR	1045..1183	CDD:214587
CHADL	XP_011528235.1	leucine-rich repeat	132..155	CDD:275380	7/23 (30%)
		LRR_RI	<133..358	CDD:238064	73/227 (32%)
		LRR_8	133..214	CDD:290566	32/81 (40%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..203	CDD:275380	11/22 (50%)
		leucine-rich repeat	204..227	CDD:275380	11/22 (50%)
		LRR_8	228..286	CDD:290566	19/59 (32%)
		leucine-rich repeat	228..251	CDD:275380	8/24 (33%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		leucine-rich repeat	276..299	CDD:275380	3/22 (14%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		LRR_8	322..380	CDD:290566	19/58 (33%)
		leucine-rich repeat	324..347	CDD:275380	6/22 (27%)
		LRR_4	346..>380	CDD:289563	13/34 (38%)
		LRRNT	463..497	CDD:214470	9/35 (26%)
		leucine-rich repeat	478..494	CDD:275380	4/16 (25%)
		LRR_RI	492..671	CDD:238064	56/330 (17%)
		leucine-rich repeat	495..518	CDD:275380	8/61 (13%)
		LRR_8	518..577	CDD:290566	13/67 (19%)
		leucine-rich repeat	519..542	CDD:275380	6/22 (27%)
		leucine-rich repeat	543..566	CDD:275380	3/22 (14%)
		LRR_8	565..625	CDD:290566	24/163 (15%)
		leucine-rich repeat	567..590	CDD:275380	7/43 (16%)
		leucine-rich repeat	591..614	CDD:275380	8/33 (24%)
		leucine-rich repeat	615..638	CDD:275380	10/94 (11%)
		LRR_8	637..698	CDD:290566	20/60 (33%)
		leucine-rich repeat	639..662	CDD:275380	7/22 (32%)
		leucine-rich repeat	663..687	CDD:275380	9/23 (39%)
		LRR_8	686..745	CDD:290566	18/58 (31%)
		leucine-rich repeat	688..712	CDD:275380	7/23 (30%)
		LRR_4	711..>744	CDD:289563	10/32 (31%)
		LRRCT	743..791	CDD:214507	5/10 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4103
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960