DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and Tlr3

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_569054.2 Gene:Tlr3 / 142980 MGIID:2156367 Length:905 Species:Mus musculus


Alignment Length:1113 Identity:239/1113 - (21%)
Similarity:397/1113 - (35%) Gaps:318/1113 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 AFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPS-LQ 172
            :|.||:||..|.:.|.|..     |:..:......||           :..:|:    .:|| :.
Mouse    11 SFGGLLSLWILLVSSTNQC-----TVRYNVADCSHLK-----------LTHIPD----DLPSNIT 55

  Fly   173 LLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSL-PDAWGASRLRR 236
            :||||.|::|......|:..                 |:|..||..||.:..| |:.  ...|..
Mouse    56 VLNLTHNQLRRLPPTNFTRY-----------------SQLAILDAGFNSISKLEPEL--CQILPL 101

  Fly   237 LQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKG 301
            |:.|:||||.:|.::.......::|..|::..|.:..:.|..|...|.|.:|.|..|.|.....|
Mouse   102 LKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLG 166

  Fly   302 LLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRN 366
            ...:||.|..|.|:.|::.:...:...|.|...|..|:||:|.|.......|:.:..|..|.:.|
Mouse   167 TGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNN 231

  Fly   367 NSIG-HIEEGAFLPLYN--LHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNC 428
            ..:. |:.|.....|.|  :..|:||.|:|.......|:||                      ..
Mouse   232 AQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGL----------------------KW 274

  Fly   429 SDLKELDLSSNQLTEVPE-AVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRI---- 488
            ::|.:||||.|.|.:|.. :...|..|:.|.|..|.|......:|..|:.|..|.|  .|.    
Mouse   275 TNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSL--KRAFTKQ 337

  Fly   489 -------GNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFL---TDINGIF 543
                   .||....||.|..|..||:..|.|.|.:...|.....::.:.|.|.|.   |..|..|
Mouse   338 SVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLSKTFTSLQTLTNETF 402

  Fly   544 ATLA--SLLWLNLSENHL--------VWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQ-EEIRVT 597
            .:||  .||.|||::||:        .|.      ..|:.||:..|.||     .||. :|.|  
Mouse   403 VSLAHSPLLTLNLTKNHISKIANGTFSWL------GQLRILDLGLNEIE-----QKLSGQEWR-- 454

  Fly   598 TLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRV 662
                           .:.|..| ::::.|...|:..::|.....|.|:     :|.:::|..:.:
Mouse   455 ---------------GLRNIFE-IYLSYNKYLQLSTSSFALVPSLQRL-----MLRRVALKNVDI 498

  Fly   663 APVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLAS 727
            :|                                                       :|.|||.:
Mouse   499 SP-------------------------------------------------------SPFRPLRN 508

  Fly   728 LSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQ 792
            |:..|                                                            
Mouse   509 LTILD------------------------------------------------------------ 513

  Fly   793 DVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGS--------LAQLVNLRVLHLEN 849
                  |..||:..:....|.|..||..|....:||..|...:        |..|.:|.:|:||:
Mouse   514 ------LSNNNIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLES 572

  Fly   850 NKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSL------PHLQY 908
            |.|..:....|::|..|:.:.|..|.|..:....|:...||..|.|..|.::|:      |..| 
Mouse   573 NGLDEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDVFGPPFQ- 636

  Fly   909 RHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCS 973
              :|..|.:..|.:.|.|:.:.....:::.....:.:....|               |.|.|...
Mouse   637 --NLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHY---------------LCNTPHHY 684

  Fly   974 DLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMWLFAHY--------- 1029
            ........:.||.:|.|....|.:::..::|:|::|||:|      .:..|..:.|         
Mouse   685 YGFPLKLFDTSSCKDSAPFELLFIISTSMLLVFILVVLLI------HIEGWRISFYWNVSVHRIL 743

  Fly  1030 GVRVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHLQ-LV 1093
            |.:..:.:.|...  |.|.|:|:.||.::|..:. :.:|......:.|:::||.......|: :|
Mouse   744 GFKEIDTQAEQFE--YTAYIIHAHKDRDWVWEHF-SPMEEQDQSLKFCLEERDFEAGVLGLEAIV 805

  Fly  1094 EGARASRKIILVLTRNLLATE-WNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYL 1157
            ...:.|||||.|:|.:||... ..|.:..:|..:::......:::|                 :|
Mouse   806 NSIKRSRKIIFVITHHLLKDPLCRRFKVHHAVQQAIEQNLDSIILI-----------------FL 853

  Fly  1158 KSVPSNRL 1165
            :::|..:|
Mouse   854 QNIPDYKL 861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380 3/5 (60%)
LRR_8 115..181 CDD:404697 16/66 (24%)
leucine-rich repeat 116..146 CDD:275380 6/29 (21%)
leucine-rich repeat 147..170 CDD:275380 1/22 (5%)
leucine-rich repeat 171..201 CDD:275380 7/29 (24%)
LRR 210..592 CDD:443914 114/411 (28%)
leucine-rich repeat 212..236 CDD:275380 8/24 (33%)
leucine-rich repeat 237..260 CDD:275380 7/22 (32%)
leucine-rich repeat 261..284 CDD:275380 5/22 (23%)
leucine-rich repeat 285..308 CDD:275380 7/22 (32%)
leucine-rich repeat 309..334 CDD:275380 6/24 (25%)
leucine-rich repeat 335..358 CDD:275380 7/22 (32%)
leucine-rich repeat 359..382 CDD:275380 6/23 (26%)
leucine-rich repeat 383..406 CDD:275380 8/22 (36%)
leucine-rich repeat 407..430 CDD:275380 0/22 (0%)
leucine-rich repeat 431..451 CDD:275380 8/20 (40%)
leucine-rich repeat 454..477 CDD:275380 7/22 (32%)
leucine-rich repeat 478..499 CDD:275380 8/31 (26%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 8/26 (31%)
leucine-rich repeat 590..617 CDD:275380 3/27 (11%)
leucine-rich repeat 618..641 CDD:275380 4/22 (18%)
leucine-rich repeat 642..689 CDD:275380 5/46 (11%)
LRRCT 679..736 CDD:214507 6/56 (11%)
LRR <775..>920 CDD:443914 36/158 (23%)
leucine-rich repeat 775..796 CDD:275380 0/20 (0%)
leucine-rich repeat 797..817 CDD:275380 5/19 (26%)
leucine-rich repeat 818..841 CDD:275380 7/30 (23%)
leucine-rich repeat 842..865 CDD:275380 8/22 (36%)
leucine-rich repeat 866..889 CDD:275380 5/22 (23%)
leucine-rich repeat 890..911 CDD:275380 7/26 (27%)
TIR 1045..1183 CDD:214587 28/123 (23%)
Tlr3NP_569054.2 LRR 3 101..122 7/20 (35%)
leucine-rich repeat 102..125 CDD:275380 7/22 (32%)
LRR 4 125..146 5/20 (25%)
leucine-rich repeat 126..149 CDD:275380 5/22 (23%)
LRR 5 149..170 6/20 (30%)
leucine-rich repeat 150..199 CDD:275380 14/48 (29%)
LRR 6 173..196 5/22 (23%)
LRR 7 199..220 7/20 (35%)
leucine-rich repeat 200..250 CDD:275380 14/49 (29%)
LRR 8 250..271 6/20 (30%)
leucine-rich repeat 251..276 CDD:275380 8/46 (17%)
LRR 9 276..297 8/20 (40%)
leucine-rich repeat 277..300 CDD:275380 9/22 (41%)
LRR 10 300..321 6/20 (30%)
leucine-rich repeat 301..324 CDD:275380 7/22 (32%)
LRR 11 324..345 4/22 (18%)
leucine-rich repeat 325..381 CDD:275380 16/57 (28%)
LRR 12 357..378 7/20 (35%)
LRR 13 381..401 5/19 (26%)
leucine-rich repeat 382..433 CDD:275380 16/56 (29%)
LRR 14 409..430 7/20 (35%)
LRR 15 433..454 9/25 (36%)
leucine-rich repeat 434..458 CDD:275380 10/45 (22%)
LRR 16 458..479 5/21 (24%)
leucine-rich repeat 459..482 CDD:275380 4/23 (17%)
LRR 17 482..502 5/79 (6%)
leucine-rich repeat 483..508 CDD:275380 9/84 (11%)
PPP1R42 503..>649 CDD:455733 42/214 (20%)
LRR 18 508..529 6/86 (7%)
leucine-rich repeat 509..532 CDD:275380 7/88 (8%)
LRR 19 532..553 6/20 (30%)
leucine-rich repeat 533..564 CDD:275380 7/30 (23%)
LRR 20 564..585 7/20 (35%)
leucine-rich repeat 565..586 CDD:275380 7/20 (35%)
LRR 21 588..609 5/20 (25%)
leucine-rich repeat 589..610 CDD:275378 5/20 (25%)
LRR 22 612..633 6/20 (30%)
leucine-rich repeat 613..637 CDD:275380 7/26 (27%)
LRRCT 646..698 CDD:214507 9/66 (14%)
Tlr3_TMD 699..731 CDD:465595 10/37 (27%)
TIR 756..901 CDD:214587 28/126 (22%)
leucine-rich repeat 37..53 CDD:275380 4/30 (13%)
LRR 1 53..74 7/20 (35%)
leucine-rich repeat 54..77 CDD:275380 7/39 (18%)
PLN00113 70..>543 CDD:215061 141/670 (21%)
LRR 2 77..98 7/22 (32%)
leucine-rich repeat 78..101 CDD:275380 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

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