DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and Toll-6

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:XP_320172.2 Gene:Toll-6 / 1280328 VectorBaseID:AGAMI1_008433 Length:1459 Species:Anopheles gambiae


Alignment Length:1303 Identity:495/1303 - (37%)
Similarity:731/1303 - (56%) Gaps:119/1303 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 MDIRCSVRALESG-TGTPLDLQVAEAAGRLDLQCSQELLHASELAPGLFRQLQKLSELRIDACKL 102
            :|:.|::|.:.|. ..|...:..||....|.:.|::.::..|:|.|..|..|.:|..|.::.||:
Mosquito    65 VDLACNLRTVNSEFDNTNFSVIPAEHTAALSILCNEAIMARSKLLPNSFVHLARLKALSLEFCKI 129

  Fly   103 QRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCS 167
            .:.......||..|:..||.:||..| |...||:...:|...:.|..|.|..|||..||:.::||
Mosquito   130 AKFSSTVLAGLGDLRNFTLRTHNIAW-PELNLEIEADAFGQTRNLEVLDLSTNNIWSLPDHLFCS 193

  Fly   168 MPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGS---------ELQTLDVSFNELR 223
            :..|:.||::.||::....|||.||.......|..:...|.||         :|:.||||.|...
Mosquito   194 LSGLRSLNISSNRLQDVNDLGFREKGVKDEVESEGHKTNSSGSVAPPVSCALDLEDLDVSRNHFV 258

  Fly   224 SLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAG-NKELRE 287
            .||.| |...|:||:.|.:..|.||.:...||:||..|::|::|.|.||:||::.|.. .:.::|
Mosquito   259 LLPAA-GFGMLKRLKMLKIHDNEISMVGDKALSGLKELQILDLSSNKLVALPTDLFRDPAQSIQE 322

  Fly   288 LHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKT 352
            ::||.|.:..|..||..:||||..||||.|||||..|:..||||||||::|||::|.:|::.|:.
Mosquito   323 IYLQNNSISVLSPGLFSKLEQLQALDLSQNQLTSAWVNRDTFAGLIRLVLLNLASNKITKLESEI 387

  Fly   353 FKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLV 417
            |.:||.||||::|:|.:..|....|.|:.|||||.|:.|:|..||....||||.|:.|:|:||.:
Mosquito   388 FSDLYTLQILNLRHNQLEIIAADTFSPMNNLHTLLLSHNKLKYLDAYSLNGLYALSLLSLDNNAL 452

  Fly   418 SIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLR 482
            :.|..:||||||.|::|:|:.|:||:||.|::|:.:|:|:|||||.||..:...||.:|.|.|||
Mosquito   453 TGVHPEAFRNCSSLQDLNLNGNELTQVPLALKDMRLLRTVDLGENSISVIEEPGFRGMNNLYGLR 517

  Fly   483 LIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLA 547
            ||.|.|.|||...|:|||.|.:||:|:|:|..||:|||:....::|||||.|.|:||:|:|.::.
Mosquito   518 LISNNIENITRKAFKDLPSLQILNVARNKISYIEKGAFEPAVSVQAIRLDGNLLSDIDGLFTSMP 582

  Fly   548 SLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAM 612
            :|:|||:|:|.|..|||:.||.:|:|||:|.|.:..|.|.|.|..::.:.|||||.||:|.:...
Mosquito   583 NLVWLNISDNKLEHFDYSHIPPHLQWLDLHRNELTELTNRYGLDNQLHLQTLDASFNRLTRVTPA 647

  Fly   613 SVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLG 677
            ::|||||.||:|:|:|..::.:.|..||.|.|||||||.|:.:.:.|||:.||..:|.:||||:|
Mosquito   648 TIPNSIEFLFLNDNLIVHVEPHCFTHKTNLTRVDLYANQLTSLDIKALRLQPVPEDKQIPEFYIG 712

  Fly   678 GNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCP 742
            ||||.|||:::|||:||::|:||:|.:.|:..:.|.:.::|.....||.......|:|.|.:||.
Mosquito   713 GNPFVCDCNIDWLQKINHVTSRQYPTINDIETVYCKLMYNRERSYIPLIEAEPKHFLCSYNTHCF 777

  Fly   743 PTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPEL 807
            ..|||||::.|:||:.||.||:|:||.:|:||||:|.......:||.||.|.:::|:||||:.||
Mosquito   778 ALCHCCEFDACDCEMTCPNNCACYHDNSWSTNIVECSAAGYTDIPNNIPMDTTEVYIDGNNLVEL 842

  Fly   808 EVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLH 872
            ......||:|||.||.|.||:..:.|.:...|..|.:||||||.:..|.|.||.:|..||||||.
Mosquito   843 SGHSFIGRKNLRVLYANHSNIEAIYNTTFIGLRRLTILHLENNAIRKLYGHEFSALESLRELYLQ 907

  Fly   873 NNMLTHISNATFEPLVSLEVLRLDNNRLSSLP--HLQYRHSLQGLTLGRNAWSCRCQQLRELAQF 935
            .|.:.:|.:.||..|..|||||||.||::|..  .|.....|..:.|..|.|:|.|..:.:|..:
Mosquito   908 GNRIAYIEDHTFAELRKLEVLRLDGNRITSFEVWQLSANPYLVEIALANNLWTCDCGFVNKLRSY 972

  Fly   936 VSDNAMVVRDAHDIYCL---DAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLP- 996
            :..||..:.||::|.|.   ...|.|:        ||..|:  .....|:|...|::..  .|| 
Mosquito   973 LQSNADKIVDANEISCSYNNATSILRD--------NGTKCT--FREGMSSIVHRQEIED--MLPL 1025

  Fly   997 LLAAVLVLIFLVVVLIIVFVFRESVRMWLFAHYGVRVCEPRF---EDAGKLYDAIILHSEKDYEF 1058
            ||.|....:....::..:|.:|:.:::|:  |.|:......|   .|..:||||.|.:|.:|..|
Mosquito  1026 LLVATCAFVGFFGLIFGIFCYRKELKVWV--HSGLCYKSGTFVNEYDKDRLYDAYITYSLQDEHF 1088

  Fly  1059 VCRNIAAELEH--GRPPFRLCIQQRDLPPQASHL--QLVEGARASRKIILVLTRNLLATEWNRIE 1119
            |.:.:.:.||:  |   ||||:..|||...| :|  .:||...:|::.||||:::.|..||.|.|
Mosquito  1089 VSQILTSTLENDIG---FRLCLHYRDLNANA-YLADTIVEAVESSKRAILVLSKSFLYNEWTRFE 1149

  Fly  1120 FRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYLKSVPSNRLLTC----DRYFWEKLRYAI 1180
            |:.|.||.|: ..:||:||....:.....| |::..||      |..||    |:.||:|||.|:
Mosquito  1150 FKGAIHEVLK-RRRKLIIILYGDLPQRDLD-ADMRLYL------RTNTCIEWDDKKFWQKLRIAL 1206

  Fly  1181 P-------------IEL-SPRGNNYTLDHHERFKQPVSPGMIFRQAPPPPAYYCTEEMEANYSSA 1231
            |             |.: :..||:|.           :||                       ..
Mosquito  1207 PHVKKSNCLNKRSAINIYATAGNDYN-----------TPG-----------------------RP 1237

  Fly  1232 TTATPSPRPTRPGGAARIVDSMPMPMRPPSEHIYHSIESEYSA-YDQHEALSMIPTGLMHQHQQQ 1295
            :|..||...||..|              |..|.|.:|...... .|.::.:|.........||..
Mosquito  1238 STLGPSVASTRLDG--------------PQHHSYATIGPNCPRNCDNYDTVSNCKYNTTQHHQTH 1288

  Fly  1296 QLR 1298
            ..|
Mosquito  1289 HER 1291

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 7/24 (29%)
leucine-rich repeat 92..115 CDD:275380 6/22 (27%)
LRR_8 115..181 CDD:404697 24/65 (37%)
leucine-rich repeat 116..146 CDD:275380 10/29 (34%)
leucine-rich repeat 147..170 CDD:275380 10/22 (45%)
leucine-rich repeat 171..201 CDD:275380 10/29 (34%)
LRR 210..592 CDD:443914 185/391 (47%)
leucine-rich repeat 212..236 CDD:275380 11/23 (48%)
leucine-rich repeat 237..260 CDD:275380 9/22 (41%)
leucine-rich repeat 261..284 CDD:275380 9/23 (39%)
leucine-rich repeat 285..308 CDD:275380 8/22 (36%)
leucine-rich repeat 309..334 CDD:275380 16/24 (67%)
leucine-rich repeat 335..358 CDD:275380 9/22 (41%)
leucine-rich repeat 359..382 CDD:275380 9/22 (41%)
leucine-rich repeat 383..406 CDD:275380 12/22 (55%)
leucine-rich repeat 407..430 CDD:275380 11/22 (50%)
leucine-rich repeat 431..451 CDD:275380 9/19 (47%)
leucine-rich repeat 454..477 CDD:275380 11/22 (50%)
leucine-rich repeat 478..499 CDD:275380 12/20 (60%)
leucine-rich repeat 502..525 CDD:275380 11/22 (50%)
leucine-rich repeat 526..548 CDD:275380 11/21 (52%)
leucine-rich repeat 590..617 CDD:275380 10/26 (38%)
leucine-rich repeat 618..641 CDD:275380 9/22 (41%)
leucine-rich repeat 642..689 CDD:275380 27/46 (59%)
LRRCT 679..736 CDD:214507 21/56 (38%)
LRR <775..>920 CDD:443914 63/146 (43%)
leucine-rich repeat 775..796 CDD:275380 8/20 (40%)
leucine-rich repeat 797..817 CDD:275380 9/19 (47%)
leucine-rich repeat 818..841 CDD:275380 9/22 (41%)
leucine-rich repeat 842..865 CDD:275380 12/22 (55%)
leucine-rich repeat 866..889 CDD:275380 11/22 (50%)
leucine-rich repeat 890..911 CDD:275380 11/22 (50%)
TIR 1045..1183 CDD:214587 56/158 (35%)
Toll-6XP_320172.2 PPP1R42 <115..>213 CDD:455733 32/98 (33%)
leucine-rich repeat 119..142 CDD:275380 6/22 (27%)
PLN00113 173..>617 CDD:215061 204/444 (46%)
leucine-rich repeat 173..196 CDD:275380 10/22 (45%)
leucine-rich repeat 247..270 CDD:275380 11/23 (48%)
leucine-rich repeat 271..294 CDD:275380 9/22 (41%)
leucine-rich repeat 295..319 CDD:275380 9/23 (39%)
leucine-rich repeat 320..343 CDD:275380 8/22 (36%)
leucine-rich repeat 344..369 CDD:275380 16/24 (67%)
leucine-rich repeat 370..393 CDD:275380 9/22 (41%)
leucine-rich repeat 394..417 CDD:275380 9/22 (41%)
leucine-rich repeat 418..441 CDD:275380 12/22 (55%)
leucine-rich repeat 442..465 CDD:275380 11/22 (50%)
leucine-rich repeat 466..488 CDD:275380 10/21 (48%)
leucine-rich repeat 489..512 CDD:275380 11/22 (50%)
leucine-rich repeat 513..534 CDD:275380 12/20 (60%)
leucine-rich repeat 537..560 CDD:275380 11/22 (50%)
leucine-rich repeat 561..583 CDD:275380 11/21 (52%)
PRK15370 <600..>690 CDD:185268 42/89 (47%)
leucine-rich repeat 631..676 CDD:275380 20/44 (45%)
LRR <819..>957 CDD:443914 60/137 (44%)
leucine-rich repeat 829..852 CDD:275380 9/22 (41%)
leucine-rich repeat 853..876 CDD:275380 9/22 (41%)
leucine-rich repeat 877..900 CDD:275380 12/22 (55%)
leucine-rich repeat 901..924 CDD:275380 11/22 (50%)
TIR 1075..1208 CDD:214587 55/144 (38%)

Return to query results.
Submit another query.