Protein Alignment 18w and LOC1270698

DIOPT Version :10

• Sequence 1: NP_476814.1
• Gene: 18w / 37277
• FlyBaseID: FBgn0287775
• Length: 1385
• Species: Drosophila melanogaster
• Sequence 2: XP_061512685.1
• Gene: LOC1270698 / 1270698
• VectorBaseID: AGAMI1_014276
• Length: 728
• Species: Anopheles gambiae
• Alignment Length: 596
• Identity: 143/596 - (23%)
• Similarity: 218/596 - (36%)
• Gaps: 183/596 - (30%)

  Fly   173 LLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRL 237
            ||:||.....|:    |...||...:..|...:....| |:.:.:..|     ||         :
Mosquito    27 LLSLTLLPTASS----FCPSLCTCESDRNLRTSCINAS-LEVVPIQLN-----PD---------V 72

  Fly   238 QTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGL 302
            :.|:|..|.| |.....||....|..|::|:|.|.:|.|:.|...
Mosquito    73 RYLNLTANQI-TNVHFTLAFYYQLESLDLSHNRLDTLGSKNFESQ-------------------- 116

  Fly   303 LHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNN 367
                |:||.|:|:.|.|.:...|  :|.||.||.:|.|.:|.|.::....|:.|..|:.|::.||
Mosquito   117 ----EKLLALNLTHNVLPALLKD--SFRGLRRLELLRLGDNQLEQVHPTAFQSLVSLRRLELPNN 175

  Fly   368 SIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNG----LYVLTKLTLNNNLVSIVESQAFRNC 428
            .:...|||...||.:|.||.||.|:|..:.   :.|    |..|..|.|:.||:..|.:.:|...
Mosquito   176 RLVSFEEGVLRPLVSLDTLLLANNQLLEVP---YGGNLEYLRSLRHLDLSGNLIEFVANDSFGTL 237

  Fly   429 SDLKELDLSSNQLTEVP-EAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNIT 492
            ..|..|.|:.|.|.|:. .....||.|:.|||.:|.::.........|..||.|.|..|....:.
Mosquito   238 HQLHTLRLAGNVLMELDWSGFSGLSALQLLDLADNNLTTIPTVQLAKLYNLTTLTLSGNSFVELP 302

  Fly   493 VGMFQDLPRLSVLNLAK-NRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSE 556
            ...||:|.:|..|:|.: :|::.|:..||..||.::.:.||.      |..|:||...|:
Mosquito   303 PVAFQNLFQLRELHLDRLDRLEHIDTRAFIDNTHLQVLTLDD------NPSFSTLPVRLF----- 356

  Fly   557 NHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELL 621
                                |||                                   |:.|::.
Mosquito   357 --------------------HGN-----------------------------------PHLIDIS 366

  Fly   622 FINNNIIGQIQANTF-VDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDC 685
            ...|.:: .:.|..| :|  ||.|:.                             |.|||..|:|
Mosquito   367 MRRNALL-TLDAVQFPLD--RLQRLK-----------------------------LAGNPLVCNC 399

  Fly   686 SMEWLQRI--------------------------NNLTTRQHPHVVDLGNIECLMPHSRSAPLRP 724
            ::.||.|:                          .|:||   ..::|...|.|.:........|.
Mosquito   400 TIRWLWRLVTGTLDDDDGDDPDGVAFLGKALADHTNITT---VLLIDKDEIGCDLNEDGLVTRRI 461

  Fly   725 LASLSASDFVC 735
            |.::|..|..|
Mosquito   462 LRNMSEGDINC 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:404697	4/7 (57%)
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380	8/27 (30%)
		LRR	210..592	CDD:443914	105/387 (27%)
		leucine-rich repeat	212..236	CDD:275380	4/23 (17%)
		leucine-rich repeat	237..260	CDD:275380	7/22 (32%)
		leucine-rich repeat	261..284	CDD:275380	8/22 (36%)
		leucine-rich repeat	285..308	CDD:275380	0/22 (0%)
		leucine-rich repeat	309..334	CDD:275380	10/24 (42%)
		leucine-rich repeat	335..358	CDD:275380	7/22 (32%)
		leucine-rich repeat	359..382	CDD:275380	9/22 (41%)
		leucine-rich repeat	383..406	CDD:275380	9/26 (35%)
		leucine-rich repeat	407..430	CDD:275380	7/22 (32%)
		leucine-rich repeat	431..451	CDD:275380	6/20 (30%)
		leucine-rich repeat	454..477	CDD:275380	6/22 (27%)
		leucine-rich repeat	478..499	CDD:275380	7/20 (35%)
		leucine-rich repeat	502..525	CDD:275380	8/23 (35%)
		leucine-rich repeat	526..548	CDD:275380	6/21 (29%)
		leucine-rich repeat	590..617	CDD:275380	1/26 (4%)
		leucine-rich repeat	618..641	CDD:275380	5/23 (22%)
		leucine-rich repeat	642..689	CDD:275380	8/46 (17%)
		LRRCT	679..736	CDD:214507	18/83 (22%)
		LRR	<775..>920	CDD:443914
		leucine-rich repeat	775..796	CDD:275380
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		leucine-rich repeat	842..865	CDD:275380
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
LOC1270698	XP_061512685.1	None