DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and LOC103911657

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	XP_009303036.2	Gene:	LOC103911657 / 103911657	-ID:	-	Length:	951	Species:	Danio rerio

Alignment Length:	1246	Identity:	259/1246 - (20%)
Similarity:	431/1246 - (34%)	Gaps:	429/1246 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CNWQYGLTTMDIRCSVRALESGTGTPLDLQVAEAAGRLDLQCSQELLHASE-------------- 80
            |:|      ::.:|  |....|...|:.   |.:|.:|::...:.:....|
Zfish    26 CSW------LNEKC--RVYSDGEEFPVK---ASSASKLNITVCRSVTDIKEDLQGLPANLLNLFV 79

  Fly    81 ---------LAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLEL 136
                     |||..|.....|.:|.|..| ...:||.||.||.::..||: |:|......|.
Zfish    80 HMDGGCHGVLAPNSFSSFASLEQLTISGC-FSEIPPEAFNGLTNVTSLTI-SYNFSENCSKV--- 139

  Fly   137 HGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGS---- 197
             ...|..|..|:.|.:.|.::..|...|:.::|.||.|.|....:|.     .||.||..|
Zfish   140 -ALDFSHLPSLTSLSISDYSLSLLASNVFETIPLLQNLILANVCLRD-----MSEVLCRLSKVKT 198

  Fly   198 ------------ALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTL 250
                        .|...|.:|...|::.|   .||                ::.::|....:..:
Zfish   199 LKHFTLKEFLLKRLQYPNCSVFNTSDIST---EFN----------------IEEVNLHFATVEHV 244

  Fly   251 APNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLS 315
            ...|      |:|.......:.|:.|..|     ||:|.|.|          :|:::.|
Zfish   245 DEGA------LKVFGKLSRFVFSVSSTDF-----LRDLSLIG----------VHKIKTL------ 282

  Fly   316 GNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPL 380
                 ...||           :||:::..       |..:||.:..:.::..:..      |.|
Zfish   283 -----DFKVD-----------LLNVADLC-------TAAKLYGINSIQVKYKTTN------FWP- 317

  Fly   381 YNLHT------LNLAENRLHT-------LD-NRIFNGLYVLTKLTLNNNLVSIVESQAFRN-CSD 430
              .||      .|:.:..|.|       || |.:|.   :.:.||:.:....::.|..|:. |:.
Zfish   318 --THTNISGGCKNIKDVMLDTILYPANLLDVNCVFQ---IFSNLTIISIYKHVLRSDDFQTLCAS 377

  Fly   431 LKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGM 495
            .             |:.|:.||   .:||...::....::.|.....|..|....::|..|....
Zfish   378 F-------------PQTVKHLS---AMDLRLKKVDTIVSHQFMCFPNLETLIFTSSKIVVIEDFA 426

  Fly   496 FQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDIN----GIFATLASLLWLNLSE 556
            |..|.:|..|||.||:|.||.|..|....|:..:.|.:|.:..|.    |.|..|:|||..:|:
Zfish   427 FIGLNKLKELNLRKNKISSIHRHTFSGLHELLVLDLQENPIIYIEPKSFGHFTNLSSLLLGDLN- 490

  Fly   557 NHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELL 621
                      .|.|:..:.:|                            :::|.. .:|:::..:
Zfish   491 ----------FPPNMSLIKLH----------------------------LSDIFG-GIPSNLSNV 516

  Fly   622 FINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCS 686
            ||::.:             |...:.:.:|......||    ..:..:..:.|          ||
Zfish   517 FISSGL-------------RPMHLMIGSNTTLNNGLN----LHIKGQYVIVE----------DC- 553

  Fly   687 MEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSA-SDFVCKYESHCPPTCHCCEY 750
                   |:|.         |.::..|..|:        |.:|. :||:.||    .|:....|:
Zfish   554 -------NSLL---------LTSVVKLQIHA--------AYMSCENDFIGKY----VPSVVSLEF 590

  Fly   751 EQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGR 815
            :            |.|.|     ||     .||:.: |::      .:|....:..:|   .|.:
Zfish   591 Q------------SMFSD-----NI-----GDLSVI-NQL------FHLKTLKLRNIE---FTNQ 623

  Fly   816 RNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHIS 880
            .|...::.|              |..|..|.|.|.::..|:|:..:.|..|.:|.|......:|.
Zfish   624 PNTGIMFHN--------------LTKLETLILSNCRIFFLDGSLTKDLKALTKLLLSAKHTVNIL 674

  Fly   881 NATFEPLVSLEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRD 945
            .:..|.||.||.:.:|              |:.......|||         |..:|.||..|
Zfish   675 QSFVEHLVHLEYIHID--------------SIDLYCSCDNAW---------LFSWVKDNRKV--- 713

  Fly   946 AHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVV 1010
              ::...:..::.....|||     :...|...|....:...||  .:.|....:|.:.||:|||
Zfish   714 --EVVVSNPSMQNLQCFIGN-----EFDQLNFVSYVKENCLFDL--DFVLFTSTSVFLCIFIVVV 769

  Fly  1011 LIIVFV--------------FRESVRMWLFAHYGVRVCEPRFEDAGKLYDAIILHSEKDYEFVCR 1061
            |:..||              |||::||.....|              .|||.:.:|.||..:|..
Zfish   770 LMYNFVGQYLKPFYHIANGWFREALRMKEKQQY--------------RYDAFVSYSGKDEHWVIE 820

  Fly  1062 NIAAELEHGRPPF-RLCIQQRDLPPQASHLQLVEGAR----ASRKIILVLTRNLLATEWNRIEFR 1121
            .:...||...||| |||:..||.  |..| .:||...    |||:.:.:::||.|.:.|..:|.:
Zfish   821 ELLPNLEQRGPPFLRLCLHSRDF--QLGH-DIVENITDSIYASRRTLCLVSRNYLNSNWCSLEMQ 882

  Fly  1122 NAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYLKSVPS------NRL---------LTCDR- 1170
            .|.:.                :..|..|:..| .:|:::||      :||         |.|.:
Zfish   883 LATYR----------------LQVEHRDILIL-VFLETIPSCLLSSHHRLARLVKTRTYLDCPQE 930

  Fly  1171 -----YFWEKL 1176
                 .||::|
Zfish   931 PEMHDAFWDRL 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380	6/47 (13%)
		leucine-rich repeat	92..115	CDD:275380	10/22 (45%)
		LRR_8	115..181	CDD:290566	17/65 (26%)
		leucine-rich repeat	116..146	CDD:275380	7/29 (24%)
		leucine-rich repeat	147..170	CDD:275380	5/22 (23%)
		leucine-rich repeat	171..201	CDD:275380	11/45 (24%)
		LRR_RI	210..464	CDD:238064	47/268 (18%)
		leucine-rich repeat	212..236	CDD:275380	3/23 (13%)
		LRR_8	235..295	CDD:290566	12/59 (20%)
		leucine-rich repeat	237..260	CDD:275380	2/22 (9%)
		leucine-rich repeat	261..284	CDD:275380	5/22 (23%)
		LRR_8	283..345	CDD:290566	11/61 (18%)
		leucine-rich repeat	285..308	CDD:275380	6/22 (27%)
		leucine-rich repeat	309..334	CDD:275380	3/24 (13%)
		LRR_8	334..393	CDD:290566	10/64 (16%)
		leucine-rich repeat	335..358	CDD:275380	4/22 (18%)
		leucine-rich repeat	359..382	CDD:275380	2/22 (9%)
		LRR_8	382..441	CDD:290566	14/73 (19%)
		leucine-rich repeat	383..406	CDD:275380	9/36 (25%)
		leucine-rich repeat	407..430	CDD:275380	5/23 (22%)
		LRR_8	431..488	CDD:290566	9/56 (16%)
		leucine-rich repeat	431..451	CDD:275380	2/19 (11%)
		leucine-rich repeat	454..477	CDD:275380	3/22 (14%)
		LRR_8	477..559	CDD:290566	28/85 (33%)
		leucine-rich repeat	478..499	CDD:275380	5/20 (25%)
		leucine-rich repeat	502..525	CDD:275380	11/22 (50%)
		leucine-rich repeat	526..548	CDD:275380	6/25 (24%)
		leucine-rich repeat	590..617	CDD:275380	2/26 (8%)
		leucine-rich repeat	618..641	CDD:275380	2/22 (9%)
		leucine-rich repeat	642..689	CDD:275380	6/46 (13%)
		LRRCT	679..736	CDD:214507	11/57 (19%)
		leucine-rich repeat	775..796	CDD:275380	4/20 (20%)
		LRR_8	797..852	CDD:290566	10/54 (19%)
		leucine-rich repeat	797..817	CDD:275380	3/19 (16%)
		leucine-rich repeat	818..841	CDD:275380	2/22 (9%)
		LRR_8	841..900	CDD:290566	17/58 (29%)
		leucine-rich repeat	842..865	CDD:275380	7/22 (32%)
		LRR_4	866..907	CDD:289563	10/40 (25%)
		leucine-rich repeat	866..889	CDD:275380	6/22 (27%)
		leucine-rich repeat	890..911	CDD:275380	3/20 (15%)
		TIR	1045..1183	CDD:214587	43/158 (27%)
LOC103911657	XP_009303036.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920