DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and cd180

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001297419.1 Gene:cd180 / 101885327 ZFINID:ZDB-GENE-070705-323 Length:665 Species:Danio rerio


Alignment Length:736 Identity:173/736 - (23%)
Similarity:266/736 - (36%) Gaps:226/736 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 SELAPGLFRQLQKLSE-LRIDACKLQRVP---PNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQ 139
            :|..|...|..|:::: ...:...||.:|   ||:.:.|..       |.|.:  |.    |:..
Zfish    22 NEATPWARRHCQQITKGYDCNDMDLQSIPDEIPNSVQILQF-------SFNYL--PA----LYNS 73

  Fly   140 SFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANG 204
            :||.||.|..|.:...:|..:.|.|:...|.|::|.||.|.:   .|:              |:.
Zfish    74 TFQRLKSLRSLDVTRCSITFIYEDVFTYQPHLEVLLLTGNPL---VFI--------------AST 121

  Fly   205 AVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLN---- 265
            |.||...|:.|.:..::::.|.|. .:..|..|:.|.|:.:||     .:|.|||:.|..|    
Zfish   122 AFSGPLALKYLSLVQSKIKQLSDI-PSENLAYLEVLDLRGSNI-----RSLNGLSNFRWQNLKSL 180

  Fly   266 ---------ISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSG--NQL 319
                     ||:|.|  .|....||    ..:..:|||...:..|..|.| .|..||.||  |::
Zfish   181 QLDLNFIDRISFNDL--QPFSNLAG----VSISFKGNDFIYIEPGAFHSL-NLSSLDFSGCLNKM 238

  Fly   320 TSHHVDNSTFAGL--IRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYN 382
            ..    :|...||  |:...|||.              ||       ..:|..:|...|.....|
Zfish   239 NI----SSLLKGLEGIKTNRLNLG--------------LY-------ETDSNVYIASAALQSFCN 278

  Fly   383 LHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEA 447
            :...:|.....|.||              |||:....:|.        ||:|||:...|..:|..
Zfish   279 IFVSDLDFQLQHFLD--------------LNNSTFHCLEG--------LKKLDLTRAHLNALPLN 321

  Fly   448 VQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNI-----------TVGMFQDL-- 499
            ...||.|..|.|.|||..:...:..||...||.|.:    .||:           ::|:.::|  
Zfish   322 TTGLSTLSHLILDENQFKDVCQSNTRNFPMLTHLSI----SGNLKKLTFSNRCLDSLGLLEELDL 382

  Fly   500 ------PR-------------LSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDIN--GIF 543
                  ||             |.:|||:...........|:...::|.:....:..|.:|  ..|
Zfish   383 SVSLVNPREPCCNNQLFGLGELKLLNLSYGSPMFWSSKPFNVTPKLEHLDFSHSVYTLLNDSSPF 447

  Fly   544 ATLASLLWLNLSENHLVWFD------YAFIP-SNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDA 601
            :.|.||..||||     |.:      :.|:. ..|:.|::.||.|         |.|:       
Zfish   448 SNLQSLRTLNLS-----WSNTDLTNVHLFVGLKALQHLNLRGNAI---------QGEV------- 491

  Fly   602 SHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKIS---------- 656
                :|:.........:|.|.::...|.....|.|.....|..:||..|...|:|          
Zfish   492 ----LTQTELFKCVPLLETLVLSACKITSFDENLFKGLRHLNHIDLSENKFVKLSTSGFYSLDFL 552

  Fly   657 -LNALR----------VAPVSAEKPVPEFYLGGNPFECDCS----MEWLQR------------IN 694
             ||..|          ||.:..|..|...|   ||..|:||    :.|:::            .|
Zfish   553 KLNFARNDITTVDVASVADLGEEGSVDLSY---NPLVCNCSNFEFIHWVKKNKVKVKHLMETFCN 614

  Fly   695 NLTTRQHPHVVDLGNIECLMP 715
            ...||    ::| ..::|.:|
Zfish   615 GTGTR----IID-AKLQCDLP 630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 3/11 (27%)
leucine-rich repeat 92..115 CDD:275380 6/26 (23%)
LRR_8 115..181 CDD:290566 19/65 (29%)
leucine-rich repeat 116..146 CDD:275380 7/29 (24%)
leucine-rich repeat 147..170 CDD:275380 5/22 (23%)
leucine-rich repeat 171..201 CDD:275380 6/29 (21%)
LRR_RI 210..464 CDD:238064 70/270 (26%)
leucine-rich repeat 212..236 CDD:275380 5/23 (22%)
LRR_8 235..295 CDD:290566 20/72 (28%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 9/35 (26%)
LRR_8 283..345 CDD:290566 19/65 (29%)
leucine-rich repeat 285..308 CDD:275380 6/22 (27%)
leucine-rich repeat 309..334 CDD:275380 9/28 (32%)
LRR_8 334..393 CDD:290566 10/58 (17%)
leucine-rich repeat 335..358 CDD:275380 4/22 (18%)
leucine-rich repeat 359..382 CDD:275380 3/22 (14%)
LRR_8 382..441 CDD:290566 14/58 (24%)
leucine-rich repeat 383..406 CDD:275380 4/22 (18%)
leucine-rich repeat 407..430 CDD:275380 4/22 (18%)
LRR_8 431..488 CDD:290566 20/56 (36%)
leucine-rich repeat 431..451 CDD:275380 7/19 (37%)
leucine-rich repeat 454..477 CDD:275380 8/22 (36%)
LRR_8 477..559 CDD:290566 25/115 (22%)
leucine-rich repeat 478..499 CDD:275380 6/31 (19%)
leucine-rich repeat 502..525 CDD:275380 5/22 (23%)
leucine-rich repeat 526..548 CDD:275380 5/23 (22%)
leucine-rich repeat 590..617 CDD:275380 3/26 (12%)
leucine-rich repeat 618..641 CDD:275380 5/22 (23%)
leucine-rich repeat 642..689 CDD:275380 19/71 (27%)
LRRCT 679..736 CDD:214507 12/53 (23%)
leucine-rich repeat 775..796 CDD:275380
LRR_8 797..852 CDD:290566
leucine-rich repeat 797..817 CDD:275380
leucine-rich repeat 818..841 CDD:275380
LRR_8 841..900 CDD:290566
leucine-rich repeat 842..865 CDD:275380
LRR_4 866..907 CDD:289563
leucine-rich repeat 866..889 CDD:275380
leucine-rich repeat 890..911 CDD:275380
TIR 1045..1183 CDD:214587
cd180NP_001297419.1 leucine-rich repeat 40..56 CDD:275380 4/15 (27%)
LRR_8 56..115 CDD:316378 20/71 (28%)
leucine-rich repeat 57..80 CDD:275380 8/35 (23%)
leucine-rich repeat 81..104 CDD:275380 5/22 (23%)
LRR_8 103..163 CDD:316378 19/77 (25%)
leucine-rich repeat 105..128 CDD:275380 10/39 (26%)
leucine-rich repeat 153..176 CDD:275380 10/27 (37%)
leucine-rich repeat 177..200 CDD:275380 5/24 (21%)
leucine-rich repeat 201..225 CDD:275380 8/28 (29%)
leucine-rich repeat 226..247 CDD:275380 7/24 (29%)
leucine-rich repeat 284..304 CDD:275378 7/33 (21%)
leucine-rich repeat 305..327 CDD:275380 8/21 (38%)
leucine-rich repeat 328..351 CDD:275380 8/22 (36%)
leucine-rich repeat 352..376 CDD:275380 5/27 (19%)
leucine-rich repeat 404..427 CDD:275380 5/22 (23%)
LRR_8 426..487 CDD:316378 17/65 (26%)
leucine-rich repeat 428..452 CDD:275380 5/23 (22%)
leucine-rich repeat 453..476 CDD:275380 7/27 (26%)
leucine-rich repeat 477..503 CDD:275380 8/45 (18%)
LRR_8 502..561 CDD:316378 14/58 (24%)
leucine-rich repeat 504..527 CDD:275380 5/22 (23%)
leucine-rich repeat 528..549 CDD:275380 6/20 (30%)
leucine-rich repeat 552..574 CDD:275380 5/21 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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