DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and tlr12

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:XP_002941870.2 Gene:tlr12 / 100498493 XenbaseID:XB-GENE-5824069 Length:936 Species:Xenopus tropicalis


Alignment Length:1088 Identity:240/1088 - (22%)
Similarity:395/1088 - (36%) Gaps:343/1088 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   193 LCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAG 257
            ||    ||.:|..:.||:                    .:..:|::.|.:: ..:..:.|||..|
 Frog    86 LC----LSGSNTFIPGGT--------------------FANFKRIKYLFMK-MPLVRIYPNAFKG 125

  Fly   258 LSSLRVLNISY------NHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRL---EQLLVLD 313
            |.||..|.||:      |:| |:|::||:....||:|.::|   ::|.|.:|..|   ..|..|.
 Frog   126 LESLESLAISFLGHSKCNNL-SIPTDAFSNLYYLRDLSIEG---FKLVKSMLIHLPFSTSLYSLS 186

  Fly   314 LSGNQLTS-HHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQI--LDMRNNSIGHIEEG 375
            |..|.:|. .||.: .|..||.:..|::.:|.:.|:..:....:....|  |.:..|.:..|::.
 Frog   187 LPTNCITDLFHVFH-IFQNLIFIHNLDVGSNKIERVSLQHDLNISLPNITELVLEKNPLILIQQN 250

  Fly   376 AFLPLYNLHTLNL-----------------------------AENRLHTL--------------- 396
            | |..:.:|.|||                             |.|:.|||               
 Frog   251 A-LARFGIHLLNLGFTKLNLEDILNAGVENLKSLSLTSACRRAINKTHTLCSIAQRFQLKSLSAP 314

  Fly   397 DNRIFNGLYV--------LTKLTLNNNLVSIVESQAFRNCSDLKELDLSSN--QLTEVPEAVQD- 450
            .|| |:|:|.        |..|.||:|.:.||:.........||||.||.:  .:...|.:.|| 
 Frog   315 VNR-FSGIYTKDFLGCSSLEFLNLNHNHIHIVDPDLLYTLPKLKELHLSYSLLHMNLCPLSYQDN 378

  Fly   451 -LSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQS 514
             .|.::.|....|:|:..||..|..:.:||.|.|..|.|.:|....|..|..|.||:|..||:.|
 Frog   379 FTSSVEALYFIGNRITVLKNKQFFCMTKLTDLLLARNGIEHIEESAFWGLNDLRVLDLRNNRLTS 443

  Fly   515 IERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGN 579
            ::                   ::.::|:                          |||..|.:..|
 Frog   444 LQ-------------------ISSLSGL--------------------------SNLMELYLQNN 463

  Fly   580 YIEALGNY-YKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLA 643
            .:|::..| .|.|.::          |:.:||.:||..|.| ||.|...: .||       |...
 Frog   464 VMESMQRYSLKWQTKL----------RLVKIGFVSVSVSFE-LFPNTETL-DIQ-------TTGK 509

  Fly   644 RVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLG 708
            .:.::.|..:..||.:|.|              .|:..|.|                        
 Frog   510 YITVFMNETAASSLKSLSV--------------NGSHVELD------------------------ 536

  Fly   709 NIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWAT 773
             |:|  .|...:.||.|..::.:                             |..||.|      
 Frog   537 -IKC--GHQFFSTLRELKVINNN-----------------------------GLISCSH------ 563

  Fly   774 NIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQ 838
                                    |  |..:...|        ||..:..:.|.....:|.:.:.
 Frog   564 ------------------------Y--GYQLEHFE--------NLENIQYHFSGAPLTRNVNFSN 594

  Fly   839 LVNLRVLHLENNKLTALE-----GTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNN 898
            :.|||.|.:| |..|||:     ...|..|..|..|.|.|....:::.|..:.:.||.||.:.|.
 Frog   595 IANLRSLEVE-NLATALDPNVPPNDLFHKLHKLEVLKLFNCGFKYMTTALLKDMRSLRVLVMKNQ 658

  Fly   899 RLSSL-PHLQYRHS-LQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELE 961
            .:.:: |.||...| |:.:......:.|.|.....:...:.|....|.....::||      :|.
 Frog   659 MILAVDPGLQNTLSPLEFIYFIDVTFQCDCDNSWFVTWALEDKHTFVSGICSLFCL------QLN 717

  Fly   962 LIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLI----------IVFV 1016
            ...||.|           .|..|..|::  .:.|.::....:|:|:|:.::          :.:|
 Frog   718 KKFNLVN-----------FSESSCRQEI--DFMLFVITFTSLLLFIVLTMLCNIFNSDIIQLFYV 769

  Fly  1017 FRESVRMWLFAHYGVRVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEH-GRPPFRLCIQQ 1080
            |    ::||....|.......:|     |||.:.:..:|..:|...:...||. ||...:||:..
 Frog   770 F----QIWLKKLRGKTNNPIAYE-----YDAFVSYCSRDQGWVVNYLVPNLEEKGRNTIKLCLHN 825

  Fly  1081 RD-LPPQASHLQLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVS 1144
            || |..:.....:::....|||.|.:::.|.|.::|..:|.|.|.::.|......|:::...|:|
 Frog   826 RDFLVGKDIVDNIMDSIYKSRKTICLISYNYLQSDWCSLEMRMATYKLLAEKNDDLILVFLESIS 890

  Fly  1145 AEAEDVAELSPYLKSVPSNRLLTCDRY------------FWEKLRYAI 1180
            .     ..||.|.:..   |::....|            |||:||..:
 Frog   891 G-----YHLSAYHRLA---RIVRKKTYIDWPQEENEQAEFWERLRMTV 930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:404697
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380 3/7 (43%)
LRR 210..592 CDD:443914 107/450 (24%)
leucine-rich repeat 212..236 CDD:275380 0/23 (0%)
leucine-rich repeat 237..260 CDD:275380 6/22 (27%)
leucine-rich repeat 261..284 CDD:275380 10/28 (36%)
leucine-rich repeat 285..308 CDD:275380 8/25 (32%)
leucine-rich repeat 309..334 CDD:275380 9/25 (36%)
leucine-rich repeat 335..358 CDD:275380 3/22 (14%)
leucine-rich repeat 359..382 CDD:275380 6/24 (25%)
leucine-rich repeat 383..406 CDD:275380 13/66 (20%)
leucine-rich repeat 407..430 CDD:275380 7/22 (32%)
leucine-rich repeat 431..451 CDD:275380 9/23 (39%)
leucine-rich repeat 454..477 CDD:275380 6/22 (27%)
leucine-rich repeat 478..499 CDD:275380 8/20 (40%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 1/21 (5%)
leucine-rich repeat 590..617 CDD:275380 6/26 (23%)
leucine-rich repeat 618..641 CDD:275380 6/22 (27%)
leucine-rich repeat 642..689 CDD:275380 8/46 (17%)
LRRCT 679..736 CDD:214507 8/56 (14%)
LRR <775..>920 CDD:443914 33/151 (22%)
leucine-rich repeat 775..796 CDD:275380 0/20 (0%)
leucine-rich repeat 797..817 CDD:275380 3/19 (16%)
leucine-rich repeat 818..841 CDD:275380 3/22 (14%)
leucine-rich repeat 842..865 CDD:275380 10/27 (37%)
leucine-rich repeat 866..889 CDD:275380 5/22 (23%)
leucine-rich repeat 890..911 CDD:275380 7/21 (33%)
TIR 1045..1183 CDD:214587 38/150 (25%)
tlr12XP_002941870.2 leucine-rich repeat 60..82 CDD:275380
leucine-rich repeat 83..105 CDD:275380 7/42 (17%)
leucine-rich repeat 106..128 CDD:275380 6/22 (27%)
leucine-rich repeat 182..207 CDD:275380 9/25 (36%)
leucine-rich repeat 208..233 CDD:275380 3/24 (13%)
LRR 226..633 CDD:443914 121/583 (21%)
leucine-rich repeat 234..279 CDD:275380 10/45 (22%)
leucine-rich repeat 308..331 CDD:275380 5/23 (22%)
leucine-rich repeat 332..355 CDD:275380 7/22 (32%)
leucine-rich repeat 356..382 CDD:275380 9/25 (36%)
leucine-rich repeat 383..406 CDD:275380 6/22 (27%)
leucine-rich repeat 407..430 CDD:275380 9/22 (41%)
leucine-rich repeat 431..454 CDD:275380 8/67 (12%)
leucine-rich repeat 455..478 CDD:275380 7/22 (32%)
TIR 788..930 CDD:214587 39/154 (25%)
Blue background indicates that the domain is not in the aligned region.

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