DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and tlr8

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:XP_002933859.2 Gene:tlr8 / 100496108 XenbaseID:XB-GENE-485083 Length:1037 Species:Xenopus tropicalis


Alignment Length:1181 Identity:257/1181 - (21%)
Similarity:411/1181 - (34%) Gaps:380/1181 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   134 LELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPS-LQLLNLTQNRIRSAEFLGFSEKLCAGS 197
            ||:..::|..|.:|.||.:..|.:.::|:|:    || :|.|:|:.|.|.|.:....|..:....
 Frog   113 LEIGNETFSYLTKLEELFIDHNFLCKIPQGI----PSTVQTLSLSYNNIFSVKKQILSPLINLKK 173

  Fly   198 ALSNAN---------------GAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNI 247
            ...|.|               |..:|.:||..||:|||.:..:|....||    |:.|.|.:|||
 Frog   174 LFLNHNCYFGNECDHVVDIEEGTFAGLTELTVLDLSFNNMTRVPAKLPAS----LKELYLSNNNI 234

  Fly   248 STLAPNALAGLSSLRVL-----------------NISYNHLVSLPSEAFAGNKELRELHLQGNDL 295
            ..:..:.|..|.:|.||                 |:.....:::...||...|.|.||||....|
 Frog   235 QIIHSDDLQNLINLEVLFLNGNCPRCFNANYPCKNLCKQISITIDPLAFQNLKNLTELHLGSTSL 299

  Fly   296 YELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIG------SKTFK 354
            ..:|........||.:|:|..|.|.:..........|..|.||:||.|...|..      |..|.
 Frog   300 RTIPPIWFQNTTQLKILNLQLNYLVNEIASADFLLNLPFLEVLDLSFNYDLRSYANNINISNHFS 364

  Fly   355 ELYFLQILDMRNNSIGHIEEGAFLPLYN---LHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNN- 415
            :|..||.|.::.....||......||.|   |.|:||..|.:..:|..:|..:..|..:.|:.| 
 Frog   365 KLISLQELHIQGYVFKHIAAKNLSPLINLPKLATINLGINFIKQVDFEVFQNISGLKLIYLSENR 429

  Fly   416 ----------LVSIVESQAFR--------------------------NCSDL-KELDLSSNQLTE 443
                      |..:.:.|::|                          .||.. |.||||.|.:..
 Frog   430 ITPFSETNKQLFGVCKDQSYRISSPGVTFPTQSNFQMTKIFSHLVKPQCSSRGKTLDLSLNSIFF 494

  Fly   444 V-PEAVQDLSMLKTLDLGENQISEFKNNT-FRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLN 506
            : ||..:..|.:..|:|..|.|.:..|.| |..|..||.|.|..|::...::..||:||.|.||:
 Frog   495 IDPEEFRSFSDVSCLNLSFNSIGQDLNGTEFIYLKNLTYLDLSFNKLDFDSINAFQELPSLEVLD 559

  Fly   507 LAKNRIQSIERGA-----FDKNTE-IEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYA 565
            |:.|....|..|.     |.:|.: ::.:.|..|.::.:.....|..||..|..|.|.|      
 Frog   560 LSYNSHYFIVDGVTHRLKFIENLQYLKVLNLSWNKISTLTDFRLTSHSLKELQFSGNRL------ 618

  Fly   566 FIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRI---TEIGAMSVPNSIELLFINNNI 627
                ::.|.:....|.|...|.|.|      |.||.|:||:   ||:...::|.|:..|::|||.
 Frog   619 ----DVLWKNEDKRYQELFKNLYNL------TCLDISYNRLNKMTEVELSNLPLSLTELYLNNNK 673

  Fly   628 IGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQR 692
            :.............|..:||..|.|:.|                                     
 Frog   674 LDYFGWKALKAYKNLKHLDLSHNKLTMI------------------------------------- 701

  Fly   693 INNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEV 757
                          :||:..   |:.|                                      
 Frog   702 --------------MGNLSI---HTYS-------------------------------------- 711

  Fly   758 ICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALY 822
                                                :|.|.:..|::..|.|..|...|||..|.
 Frog   712 ------------------------------------LSSLIISYNSISSLPVAFLHKSRNLSELD 740

  Fly   823 LNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPL 887
            |:.::|.::                  |....|.|:|              |.||.:        
 Frog   741 LSFNHLKSI------------------NSSVFLSGSE--------------NYLTVL-------- 765

  Fly   888 VSLEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVS----DNAMVVRDAHD 948
                                   .|:|     |.:.|.|    |:..|:|    :|..:.|.|.|
 Frog   766 -----------------------GLKG-----NPFVCTC----EITDFISWIYANNVTIPRLATD 798

  Fly   949 IYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLII 1013
            :.|.....|:...:|           ..|....      ||.|...:....:|.:::.:.|:.|:
 Frog   799 VNCAAPENKKGSGII-----------FFDVHTC------DLDGAAMILYFFSVFLVMSITVLPIL 846

  Fly  1014 VFVFRESVRMWLFAHYGV------RVCEPRFEDAGKLYDAIILHSEKD-------YEFVCRNIAA 1065
            :.||  |..:|...|..|      :||:.:.     |||..|.:..||       :..:|:::. 
 Frog   847 INVF--SWDLWYVYHLCVAKLRWHKVCKSKC-----LYDVFITYDNKDPNVSDWIFNELCQHLE- 903

  Fly  1066 ELEHGRPPFRLCIQQRDLPPQASHL-QLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLR 1129
              :.|.....||:::||..|..:.: .|......|.|.:.|||:..:.:.    :|:.||:.:|:
 Frog   904 --DKGDKHMYLCLEERDWEPGKAIIDNLAHSINQSNKTLFVLTKKYVKSG----KFKTAFYLALQ 962

  Fly  1130 GLAQKLVIIEETSVSAEAEDVAELSPYLK--------SV---PSNRLLTCDRYFWEKLRYAIPIE 1183
            .|..:.:   :..|....|.|.:.|.||:        |:   |.|.  ....:||::::..:..:
 Frog   963 KLMDENM---DVIVIVLLEPVLQNSQYLRLRRKICKSSIMEWPKNP--NTKSFFWQRMKNVLLTD 1022

  Fly  1184 LSPRGNNYTLD 1194
            ...|.||:..|
 Frog  1023 NCNRYNNFYTD 1033

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566 16/47 (34%)
leucine-rich repeat 116..146 CDD:275380 4/11 (36%)
leucine-rich repeat 147..170 CDD:275380 6/22 (27%)
leucine-rich repeat 171..201 CDD:275380 7/29 (24%)
LRR_RI 210..464 CDD:238064 84/318 (26%)
leucine-rich repeat 212..236 CDD:275380 9/23 (39%)
LRR_8 235..295 CDD:290566 20/76 (26%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 6/39 (15%)
LRR_8 283..345 CDD:290566 21/61 (34%)
leucine-rich repeat 285..308 CDD:275380 7/22 (32%)
leucine-rich repeat 309..334 CDD:275380 6/24 (25%)
LRR_8 334..393 CDD:290566 23/67 (34%)
leucine-rich repeat 335..358 CDD:275380 10/28 (36%)
leucine-rich repeat 359..382 CDD:275380 7/22 (32%)
LRR_8 382..441 CDD:290566 22/99 (22%)
leucine-rich repeat 383..406 CDD:275380 7/22 (32%)
leucine-rich repeat 407..430 CDD:275380 7/59 (12%)
LRR_8 431..488 CDD:290566 22/59 (37%)
leucine-rich repeat 431..451 CDD:275380 8/21 (38%)
leucine-rich repeat 454..477 CDD:275380 8/23 (35%)
LRR_8 477..559 CDD:290566 26/87 (30%)
leucine-rich repeat 478..499 CDD:275380 7/20 (35%)
leucine-rich repeat 502..525 CDD:275380 9/27 (33%)
leucine-rich repeat 526..548 CDD:275380 3/21 (14%)
leucine-rich repeat 590..617 CDD:275380 10/29 (34%)
leucine-rich repeat 618..641 CDD:275380 4/22 (18%)
leucine-rich repeat 642..689 CDD:275380 6/46 (13%)
LRRCT 679..736 CDD:214507 4/56 (7%)
leucine-rich repeat 775..796 CDD:275380 0/20 (0%)
LRR_8 797..852 CDD:290566 12/54 (22%)
leucine-rich repeat 797..817 CDD:275380 5/19 (26%)
leucine-rich repeat 818..841 CDD:275380 4/22 (18%)
LRR_8 841..900 CDD:290566 7/58 (12%)
leucine-rich repeat 842..865 CDD:275380 4/22 (18%)
LRR_4 866..907 CDD:289563 3/40 (8%)
leucine-rich repeat 866..889 CDD:275380 3/22 (14%)
leucine-rich repeat 890..911 CDD:275380 0/20 (0%)
TIR 1045..1183 CDD:214587 34/156 (22%)
tlr8XP_002933859.2 leucine-rich repeat 45..64 CDD:275380
leucine-rich repeat 66..87 CDD:275380
leucine-rich repeat 88..125 CDD:275380 4/11 (36%)
leucine-rich repeat 126..145 CDD:275380 6/22 (27%)
PLN00113 132..>563 CDD:215061 118/438 (27%)
leucine-rich repeat 147..170 CDD:275380 7/22 (32%)
leucine-rich repeat 171..202 CDD:275380 4/30 (13%)
leucine-rich repeat 203..223 CDD:275380 7/19 (37%)
leucine-rich repeat 224..247 CDD:275380 8/22 (36%)
leucine-rich repeat 248..288 CDD:275380 6/39 (15%)
leucine-rich repeat 289..312 CDD:275380 7/22 (32%)
leucine-rich repeat 313..338 CDD:275380 6/24 (25%)
leucine-rich repeat 339..368 CDD:275380 10/28 (36%)
leucine-rich repeat 400..419 CDD:275380 5/18 (28%)
leucine-rich repeat 483..505 CDD:275380 8/21 (38%)
leucine-rich repeat 509..530 CDD:275380 8/20 (40%)
leucine-rich repeat 531..554 CDD:275380 8/22 (36%)
leucine-rich repeat 555..584 CDD:275380 9/28 (32%)
leucine-rich repeat 585..607 CDD:275380 3/21 (14%)
PPP1R42 588..772 CDD:411060 61/395 (15%)
leucine-rich repeat 608..638 CDD:275380 9/39 (23%)
leucine-rich repeat 639..663 CDD:275380 10/29 (34%)
leucine-rich repeat 664..687 CDD:275380 4/22 (18%)
leucine-rich repeat 688..711 CDD:275380 9/76 (12%)
leucine-rich repeat 712..735 CDD:275380 6/22 (27%)
leucine-rich repeat 736..754 CDD:275380 5/35 (14%)
TPKR_C2 770..>809 CDD:417692 12/42 (29%)
TIR_2 877..1014 CDD:419986 34/148 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm14092
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.920

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