DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and lrrc8a

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:XP_002935552.1 Gene:lrrc8a / 100492279 XenbaseID:XB-GENE-1012024 Length:809 Species:Xenopus tropicalis


Alignment Length:584 Identity:143/584 - (24%)
Similarity:228/584 - (39%) Gaps:151/584 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 TIIAVAACLLLLVADAHAQQQCNWQYGLTTM--DIRCSVRALESGTGTPLDLQVAEAAGRLDLQC 71
            |||.|...:::|         |...|.::::  |:.|.| .:||.||..:            .:|
 Frog   267 TIIKVIKFIIIL---------CYTVYYVSSIKFDVDCKV-DIESLTGYRM------------YRC 309

  Fly    72 SQELLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLEL 136
            :..|....::....:..|.                  .|.||:.:..|.       |...::|:.
 Frog   310 AHPLATLFKILASFYISLV------------------GFYGLVCVYTLW-------WMLRRSLKK 349

  Fly   137 HGQSFQGLKELSE--------------LHL-------------------GDNNIRQLPEGVWCSM 168
            :  ||:.::|.|.              |||                   .:|.:|||......::
 Frog   350 Y--SFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNHEWTL 412

  Fly   169 PSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAW---G 230
            ..|: ..:|:|.....|...|        .||.....|....||:.|     :|..:||..   .
 Frog   413 DKLR-QRITKNSQEKLELHLF--------MLSGIPDTVFDLVELEVL-----KLELIPDVTIPPS 463

  Fly   231 ASRLRRLQTLSLQHNNISTLAPNALAGL-SSLRVLNISYNHLVSLPSEAFAGNKELRELHLQG-- 292
            .::|..|:.|.|.|......|| |||.| .:|:.|:|.:..:..:|...:: .|.|.||||.|  
 Frog   464 IAQLTGLKELWLYHTAAKIEAP-ALAFLRENLKSLHIKFTDIKEIPLWIYS-LKNLEELHLTGNL 526

  Fly   293 ---NDLYELPKGLLHRLEQLLVLDLSGN-------------QLTSHHVDN--------STFAGLI 333
               |:.|.:..| |..|::|.||.|..|             .|....|:|        ::...::
 Frog   527 SAENNRYIVIDG-LRELKRLKVLRLKSNLTKLPQVVTDVGVHLQKLSVNNEGTKLMVLNSLKKMV 590

  Fly   334 RLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEE-GAFLPLYNLHTLNLAENRLHTLD 397
            .|..|.|....|.||....| .|:.||.:|:::|::..||| .:|..|:.|..|.|..|.:..:.
 Frog   591 NLTELELVRCDLERIPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIP 654

  Fly   398 NRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGEN 462
            .:|.| |..|.:|.||.|.:..:.:|.|. |..|:.||||.|.|:.:|..:..|..|:.|.:..|
 Frog   655 IQIGN-LASLERLYLNRNKIEKIPTQLFL-CRKLRHLDLSHNSLSSIPPEIGHLQSLQYLAVTAN 717

  Fly   463 QISEFKNNTF-----RNLNQLTG-LRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQ--SIERG 518
            .|.......|     |.||.... |:.:.:|:|.:|        .||.:.|..||::  .:|.|
 Frog   718 HIENLPAELFLCKKLRTLNLGNNVLQSLPSRVGELT--------NLSQVELRGNRLEYLPVELG 773

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 3/24 (13%)
leucine-rich repeat 92..115 CDD:275380 3/22 (14%)
LRR_8 115..181 CDD:404697 17/98 (17%)
leucine-rich repeat 116..146 CDD:275380 5/29 (17%)
leucine-rich repeat 147..170 CDD:275380 8/55 (15%)
leucine-rich repeat 171..201 CDD:275380 6/29 (21%)
LRR 210..592 CDD:443914 101/348 (29%)
leucine-rich repeat 212..236 CDD:275380 6/26 (23%)
leucine-rich repeat 237..260 CDD:275380 10/23 (43%)
leucine-rich repeat 261..284 CDD:275380 4/22 (18%)
leucine-rich repeat 285..308 CDD:275380 11/27 (41%)
leucine-rich repeat 309..334 CDD:275380 8/45 (18%)
leucine-rich repeat 335..358 CDD:275380 8/22 (36%)
leucine-rich repeat 359..382 CDD:275380 9/23 (39%)
leucine-rich repeat 383..406 CDD:275380 7/22 (32%)
leucine-rich repeat 407..430 CDD:275380 8/22 (36%)
leucine-rich repeat 431..451 CDD:275380 8/19 (42%)
leucine-rich repeat 454..477 CDD:275380 7/27 (26%)
leucine-rich repeat 478..499 CDD:275380 4/21 (19%)
leucine-rich repeat 502..525 CDD:275380 7/19 (37%)
leucine-rich repeat 526..548 CDD:275380
leucine-rich repeat 590..617 CDD:275380
leucine-rich repeat 618..641 CDD:275380
leucine-rich repeat 642..689 CDD:275380
LRRCT 679..736 CDD:214507
LRR <775..>920 CDD:443914
leucine-rich repeat 775..796 CDD:275380
leucine-rich repeat 797..817 CDD:275380
leucine-rich repeat 818..841 CDD:275380
leucine-rich repeat 842..865 CDD:275380
leucine-rich repeat 866..889 CDD:275380
leucine-rich repeat 890..911 CDD:275380
TIR 1045..1183 CDD:214587
lrrc8aXP_002935552.1 Pannexin_like 1..339 CDD:463622 20/111 (18%)
leucine-rich repeat 425..446 CDD:275380 5/28 (18%)
leucine-rich repeat 447..469 CDD:275380 6/26 (23%)
leucine-rich repeat 470..493 CDD:275380 10/23 (43%)
LRR 489..>807 CDD:443914 85/298 (29%)
leucine-rich repeat 494..516 CDD:275380 4/22 (18%)
leucine-rich repeat 517..544 CDD:275380 11/27 (41%)
leucine-rich repeat 592..614 CDD:275380 8/22 (36%)
leucine-rich repeat 615..639 CDD:275380 9/23 (39%)
leucine-rich repeat 640..662 CDD:275380 7/22 (32%)
leucine-rich repeat 663..685 CDD:275380 8/22 (36%)
leucine-rich repeat 686..708 CDD:275380 9/21 (43%)
leucine-rich repeat 709..731 CDD:275380 5/21 (24%)
leucine-rich repeat 732..754 CDD:275380 7/29 (24%)
leucine-rich repeat 755..775 CDD:275380 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

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