DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 18w and cd180

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	XP_031762487.1	Gene:	cd180 / 100489673	XenbaseID:	XB-GENE-489949	Length:	571	Species:	Xenopus tropicalis

Alignment Length:	474	Identity:	115/474 - (24%)
Similarity:	180/474 - (37%)	Gaps:	117/474 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 QELLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESH---------NAVW 128
            |..:.|:.|.||..  ..:|..:::|...:|      |..:..|:.|.: ||         |:::
Frog    67 QRAISAARLFPGPL--ALELINVKVDWAHVQ------FRSMKHLRPLPV-SHRQYCLVKEINSLF 122

  Fly   129 GPGKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKL 193
            .      |:..:|..||.:|.|.|...||..|.|.|:.:...|..|.|..|.|
Frog   123 A------LYHTTFMRLKCISPLDLTRCNINLLYEDVFQNNIHLNTLVLIGNPI------------ 169

  Fly   194 CAGSALSNANGAVSGGSELQTL---DVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNAL 255
                 |..|..|.:|...|:.|   .:....:..:|    ...|:.|:|||..:|.||:|.....
Frog   170 -----LYIAASAFNGPLALKHLFLQQIPLTNVTFIP----LEHLQHLETLSFGNNFISSLQLPHN 225

  Fly   256 AGLSSLRVLNISYN--HLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQ 318
            ..:.:||||:...|  .:::...|....:..| .|.|:|||:..:.......: .|..|||.||
Frog   226 FPIKNLRVLDFQSNCXKILAADVEILKQSNNL-SLILKGNDIEYIEPNSFDSV-NLYSLDLKGN- 287

  Fly   319 LTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNL 383
                           |..:.||       :.|..|..|..:|.||:...   |:|....|...||
Frog   288 ---------------RGDLANL-------LSSTAFSCLTTIQRLDLTGT---HVESLPLLKYLNL 327

  Fly   384 HTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCS----------------DLK 432
            ..:|:..:                     |.||:..:|||.|.|..                .|:
Frog   328 SRMNINAS---------------------NENLLKGLESQTFLNMERPPSIWELYNIFLQALHLE 371

  Fly   433 ELDLSSNQLTEVP-EAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMF 496
            .|.|.|..||.:. .|...|:.|:..||..|:|:.|.:|.||:|:.: .|....|.|.:|...:.
Frog   372 VLILLSCNLTAIEHRAFHKLAKLQYEDLRHNKITIFSSNAFRDLSHI-HLNFASNMISDIASHLL 435

  Fly   497 QDLPRLSVLNLAKNRIQSI 515
            .::...|.:||:.|.|..:
Frog   436 HNISGTSAINLSHNPIDCL 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380	5/17 (29%)
		leucine-rich repeat	92..115	CDD:275380	4/22 (18%)
		LRR_8	115..181	CDD:290566	21/74 (28%)
		leucine-rich repeat	116..146	CDD:275380	8/38 (21%)
		leucine-rich repeat	147..170	CDD:275380	8/22 (36%)
		leucine-rich repeat	171..201	CDD:275380	6/29 (21%)
		LRR_RI	210..464	CDD:238064	65/275 (24%)
		leucine-rich repeat	212..236	CDD:275380	4/26 (15%)
		LRR_8	235..295	CDD:290566	19/61 (31%)
		leucine-rich repeat	237..260	CDD:275380	8/22 (36%)
		leucine-rich repeat	261..284	CDD:275380	6/24 (25%)
		LRR_8	283..345	CDD:290566	15/61 (25%)
		leucine-rich repeat	285..308	CDD:275380	6/22 (27%)
		leucine-rich repeat	309..334	CDD:275380	6/24 (25%)
		LRR_8	334..393	CDD:290566	15/58 (26%)
		leucine-rich repeat	335..358	CDD:275380	5/22 (23%)
		leucine-rich repeat	359..382	CDD:275380	6/22 (27%)
		LRR_8	382..441	CDD:290566	15/74 (20%)
		leucine-rich repeat	383..406	CDD:275380	2/22 (9%)
		leucine-rich repeat	407..430	CDD:275380	8/38 (21%)
		LRR_8	431..488	CDD:290566	20/57 (35%)
		leucine-rich repeat	431..451	CDD:275380	7/20 (35%)
		leucine-rich repeat	454..477	CDD:275380	10/22 (45%)
		LRR_8	477..559	CDD:290566	9/39 (23%)
		leucine-rich repeat	478..499	CDD:275380	4/20 (20%)
		leucine-rich repeat	502..525	CDD:275380	5/14 (36%)
		leucine-rich repeat	526..548	CDD:275380
		leucine-rich repeat	590..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
cd180	XP_031762487.1	inl_like_NEAT_1	<71..>326	CDD:411101	76/318 (24%)
		leucine-rich repeat	138..158	CDD:275380	7/19 (37%)
		leucine-rich repeat	159..182	CDD:275380	9/39 (23%)
		leucine-rich repeat	183..206	CDD:275380	4/26 (15%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..256	CDD:275380	6/24 (25%)
		leucine-rich repeat	257..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..305	CDD:275380	12/48 (25%)
		leucine-rich repeat	322..345	CDD:275380	7/43 (16%)
		LRR_8	369..427	CDD:404697	20/58 (34%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	10/22 (45%)
		leucine-rich repeat	418..440	CDD:275380	4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010