DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and tlr3

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:XP_002934448.3 Gene:tlr3 / 100486223 XenbaseID:XB-GENE-491049 Length:897 Species:Xenopus tropicalis


Alignment Length:1013 Identity:229/1013 - (22%)
Similarity:383/1013 - (37%) Gaps:271/1013 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 LQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPS 276
            ::.||:|.|:|:.||.| ..|...:|:.|....|.:....|.....|..|:.||:.:|....:..
 Frog    51 IKALDLSHNQLKKLPAA-NLSVYDQLERLDAGFNTLHQFEPALCKQLLMLKTLNLEHNEFTKISE 114

  Fly   277 EAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLS 341
            ..|.....|.||||..|.:..:......:||.||.||:|.|::.|..:.|.  ..|..|..|.|:
 Frog   115 NDFTFCVHLSELHLASNGISNIDGNPFEKLENLLFLDMSHNKMISTALGNK--QQLNNLKELYLN 177

  Fly   342 NNALTRIGSKTFKEL--YFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRL----------- 393
            :|.::::..:.|:.|  ..||.||:.:|.:..|..|.|..:.:...|.:...:|           
 Frog   178 SNKISKLNKEAFEFLANTSLQKLDLSSNPLTEINPGCFQAIGSFAALVIQNTQLDPQRTEQVCSE 242

  Fly   394 --HTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSD--LKELDLSSNQLTEVP-EAVQDLSM 453
              ||          .:..|||||..:|.:.:..|:..:|  |..||||.|.|:::. ::...|..
 Frog   243 LAHT----------GVRNLTLNNIRLSKIRNTTFKGLADTNLTVLDLSGNSLSQIDNDSFVSLGA 297

  Fly   454 LKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVG--MFQDLPRLSVLNLAKNRIQSIE 516
            |:.|:|..|.||.....||..|:::..|.|..:...|:.:.  .||.|..:..||:..|:|.||.
 Frog   298 LEILNLENNDISHVNPKTFNGLSKVRVLNLRKSLSSNLKLDDLSFQSLHNVQYLNMEANKIISIT 362

  Fly   517 RGAFDKNTEIEAIRLDKNFL---TDINGIFATLAS--LLWLNLSENHLVWFDY-AFI-PSNLKWL 574
            ...|...|.:..:.|..:.|   |..|..|.:|:.  |..|||::..|...:. ||: ..:|:.|
 Frog   363 EHTFIGLTSLTNLSLSDSTLQQHTLTNRTFLSLSKSPLYHLNLTKTGLTKIENGAFLCLKHLQLL 427

  Fly   575 D---------IHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQ 630
            |         :.||.:|.|.|                               ||:::::.|....
 Frog   428 DMGLNQIDQEVSGNELEGLAN-------------------------------IEMIYLSYNRRIT 461

  Fly   631 IQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINN 695
            :.:|:|:....|:::.|....|:...||.                   :||:.         :.|
 Frog   462 LTSNSFIFAPSLSKLYLRKTALTFRDLNP-------------------SPFKV---------LQN 498

  Fly   696 LTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICP 760
            ||      |:||.|                                                   
 Frog   499 LT------VLDLSN--------------------------------------------------- 506

  Fly   761 GNCSCFHDATWATNIVDCGRQDLAALPN-RIPQDVSDLYLDGNNMPEL--------EVGHLTGRR 816
                        .||.:.......:|.| ||      |..:.||:..|        .|..|.|.:
 Frog   507 ------------NNIANIQEDVFESLSNLRI------LSFEHNNLARLWKEANPGGPVLFLKGLK 553

  Fly   817 NLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISN 881
            ||..|.|.::....:...:...|..|:||.:..|.:..|..:.|.....|..|.||.|::|.:..
 Frog   554 NLEKLSLLSNGFDEIPANAFKGLCKLKVLDIGENNVYILPPSVFDDQHSLTLLDLHKNLITSVEQ 618

  Fly   882 ATFEPLVSLEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDA 946
            ..|:.:.|                     ||:.|.:|.|.:.|.|:.:...|.:::.....|..|
 Frog   619 DLFKNVFS---------------------SLKYLNMGGNPYDCTCESIAWFASWLNTTNTSVPLA 662

  Fly   947 HDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVL 1011
            |..|..:...:.....:.|..:.| |.:|               ..:||.:....|:|:|::.||
 Frog   663 HSQYICNTPARYHGNPVDNFDSSP-CKEL---------------APFRLFVSTFSLMLVFILSVL 711

  Fly  1012 IIVFVFRESVRMWLFAHY---------GVRVCEPR---FEDAGKLYDAIILHSEKDYEFVCRNIA 1064
            :|.|      :.|....|         |.:..:||   |:     |||.|:|::.|..:|..::.
 Frog   712 LIQF------QGWRIHFYWTVSINRILGFKEIDPRKRNFD-----YDAYIIHAQNDVSWVENHLI 765

  Fly  1065 AELEHGRPPFRLCIQQRDLPPQASHLQ-LVEGARASRKIILVLTRNLLATEW-NRIEFRNAFHES 1127
            ...::.....:.|.::|||....|.|. .|:....|||||.|:|||||...| .|.:.::||.::
 Frog   766 PLEKNAGSKLQFCFEERDLEAGTSTLSAFVDCINRSRKIIFVVTRNLLNDSWCRRFKVQHAFQQA 830

  Fly  1128 LRGLAQKLVIIEETSVSAEAEDVAELSPYLKSVPSNRL 1165
            :......:::|                 :|:.:|..:|
 Frog   831 IEQNRDSIILI-----------------FLEDIPDYKL 851

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR_RI 210..464 CDD:238064 74/269 (28%)
leucine-rich repeat 212..236 CDD:275380 9/23 (39%)
LRR_8 235..295 CDD:290566 16/59 (27%)
leucine-rich repeat 237..260 CDD:275380 5/22 (23%)
leucine-rich repeat 261..284 CDD:275380 5/22 (23%)
LRR_8 283..345 CDD:290566 21/61 (34%)
leucine-rich repeat 285..308 CDD:275380 7/22 (32%)
leucine-rich repeat 309..334 CDD:275380 9/24 (38%)
LRR_8 334..393 CDD:290566 15/60 (25%)
leucine-rich repeat 335..358 CDD:275380 6/24 (25%)
leucine-rich repeat 359..382 CDD:275380 8/22 (36%)
LRR_8 382..441 CDD:290566 18/73 (25%)
leucine-rich repeat 383..406 CDD:275380 4/35 (11%)
leucine-rich repeat 407..430 CDD:275380 7/22 (32%)
LRR_8 431..488 CDD:290566 19/57 (33%)
leucine-rich repeat 431..451 CDD:275380 7/20 (35%)
leucine-rich repeat 454..477 CDD:275380 9/22 (41%)
LRR_8 477..559 CDD:290566 24/88 (27%)
leucine-rich repeat 478..499 CDD:275380 5/22 (23%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 6/24 (25%)
leucine-rich repeat 590..617 CDD:275380 0/26 (0%)
leucine-rich repeat 618..641 CDD:275380 5/22 (23%)
leucine-rich repeat 642..689 CDD:275380 7/46 (15%)
LRRCT 679..736 CDD:214507 9/56 (16%)
leucine-rich repeat 775..796 CDD:275380 5/21 (24%)
LRR_8 797..852 CDD:290566 16/62 (26%)
leucine-rich repeat 797..817 CDD:275380 7/27 (26%)
leucine-rich repeat 818..841 CDD:275380 4/22 (18%)
LRR_8 841..900 CDD:290566 14/58 (24%)
leucine-rich repeat 842..865 CDD:275380 6/22 (27%)
LRR_4 866..907 CDD:289563 8/40 (20%)
leucine-rich repeat 866..889 CDD:275380 7/22 (32%)
leucine-rich repeat 890..911 CDD:275380 0/20 (0%)
TIR 1045..1183 CDD:214587 33/123 (27%)
tlr3XP_002934448.3 PLN00113 26..>507 CDD:215061 133/596 (22%)
leucine-rich repeat 54..74 CDD:275380 9/20 (45%)
leucine-rich repeat 75..98 CDD:275380 5/22 (23%)
leucine-rich repeat 99..122 CDD:275380 5/22 (23%)
leucine-rich repeat 123..146 CDD:275380 7/22 (32%)
leucine-rich repeat 147..170 CDD:275380 9/24 (38%)
leucine-rich repeat 171..196 CDD:275380 6/24 (25%)
leucine-rich repeat 197..230 CDD:275380 9/32 (28%)
leucine-rich repeat 231..273 CDD:275380 11/51 (22%)
leucine-rich repeat 274..297 CDD:275380 8/22 (36%)
leucine-rich repeat 298..319 CDD:275380 8/20 (40%)
leucine-rich repeat 322..347 CDD:275380 6/24 (25%)
leucine-rich repeat 348..371 CDD:275380 7/22 (32%)
leucine-rich repeat 424..448 CDD:275380 7/23 (30%)
PPP1R42 446..637 CDD:411060 57/345 (17%)
leucine-rich repeat 449..472 CDD:275380 5/22 (23%)
leucine-rich repeat 473..498 CDD:275380 7/52 (13%)
leucine-rich repeat 499..522 CDD:275380 9/91 (10%)
leucine-rich repeat 523..554 CDD:275380 9/36 (25%)
leucine-rich repeat 555..578 CDD:275380 4/22 (18%)
leucine-rich repeat 579..602 CDD:275380 6/22 (27%)
leucine-rich repeat 603..623 CDD:275380 7/19 (37%)
PCC 607..>689 CDD:188093 21/103 (20%)
Tlr3_TMD 691..720 CDD:407816 10/34 (29%)
TIR 746..890 CDD:214587 33/123 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm14092
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.920

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