DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and si:dkey-182i3.11

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:XP_021322095.1 Gene:si:dkey-182i3.11 / 100334238 ZFINID:ZDB-GENE-121214-258 Length:710 Species:Danio rerio


Alignment Length:651 Identity:171/651 - (26%)
Similarity:275/651 - (42%) Gaps:138/651 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 KLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVW 165
            |:|.:|...|..|..|. ||....|.      :|..:.||.:|   |:.||||.|.:|.|....:
Zfish    93 KIQALPNETFHELRVLD-LTKNVFNL------SLNTNWQSVRG---LTHLHLGGNRLRALTPRQF 147

  Fly   166 CSMPSLQLLNLTQNRIRSAE--FLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSL--- 225
            ..:.:||:|:|:.|.|:|..  ||                   .|...||||:::.|::.||   
Zfish   148 EGLLNLQVLDLSNNAIKSLPQMFL-------------------YGLINLQTLNLNINQILSLSYG 193

  Fly   226 ----PDAWGASRLR----------------RLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNH 270
                |.|....:||                .|..|.|..|.:.::...:..|.:.|..|::..|.
Zfish   194 VLEGPLALTDLQLRDNMIDMIEMNVFENCTYLAKLYLSKNKLKSVGNGSFKGATGLNHLDLGLNG 258

  Fly   271 LVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRL 335
            |..:|:........|..|:||.||:..:|..:...:..|..||||.|.|.|  :.|.:|..|.:|
Zfish   259 LAGIPTIVLQETSNLTSLYLQKNDITSIPDNVFSEILSLKHLDLSYNGLVS--ISNGSFRSLSQL 321

  Fly   336 IVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRI 400
            :.|:||.|.|..:....|::|..|:.|::.:|.:..:....|..|..|..|.|..|.:..:...:
Zfish   322 VYLDLSFNQLQTLTQHVFEDLGKLENLNLYHNKLTSLPNNMFKNLTMLKELQLDSNNISVIPPDL 386

  Fly   401 FNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPE------------------- 446
            |:.|..|..|.|:||.:|.:.|..|:....||:||:|||.||::|.                   
Zfish   387 FHPLSALKDLQLDNNHISKLHSHTFKKLRQLKQLDISSNDLTKIPNHLFHKNLKELNLENNHISF 451

  Fly   447 ----AVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNL 507
                :.::|..|::|.|..|.:|:.......||.:|..|.|.:|:|..|.||.|:.|..|.||:|
Zfish   452 ISKFSFKNLHRLQSLKLSHNNLSKLYRELLTNLTRLRELLLNENQIETIPVGFFKGLENLRVLDL 516

  Fly   508 AKNRIQSIERGAFDKNTEIEAIRLDKNFLTDI-NGIFATLASLLWLNLSENHLVWFDYAFIPSNL 571
            :.|::..|...||:..:.::.:.|..|||.:: ..|||:|.:|..|:|..|.|     .::||.|
Zfish   517 SNNKMHFILPDAFNDLSALKDLDLSFNFLHNLPEDIFASLRNLTKLHLQNNKL-----RYLPSRL 576

  Fly   572 KWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTF 636
                                                    .|....:|.|.::.|.|.:|....|
Zfish   577 ----------------------------------------FSALVGLEELHLDRNYIQRIHPTQF 601

  Fly   637 VDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSM-----EWLQRINNL 696
            ....:|..:|:.:|.|..:....|  .|:   :.:...:|.|||::|...:     :|   .||.
Zfish   602 EGLVKLHELDMKSNQLRSMEDGTL--MPL---RKLKRIHLDGNPWDCSTVVILYISQW---FNNN 658

  Fly   697 T 697
            |
Zfish   659 T 659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380 5/13 (38%)
LRR_8 115..181 CDD:290566 21/65 (32%)
leucine-rich repeat 116..146 CDD:275380 8/29 (28%)
leucine-rich repeat 147..170 CDD:275380 8/22 (36%)
leucine-rich repeat 171..201 CDD:275380 9/31 (29%)
LRR_RI 210..464 CDD:238064 81/299 (27%)
leucine-rich repeat 212..236 CDD:275380 11/46 (24%)
LRR_8 235..295 CDD:290566 16/75 (21%)
leucine-rich repeat 237..260 CDD:275380 5/22 (23%)
leucine-rich repeat 261..284 CDD:275380 5/22 (23%)
LRR_8 283..345 CDD:290566 23/61 (38%)
leucine-rich repeat 285..308 CDD:275380 7/22 (32%)
leucine-rich repeat 309..334 CDD:275380 11/24 (46%)
LRR_8 334..393 CDD:290566 17/58 (29%)
leucine-rich repeat 335..358 CDD:275380 8/22 (36%)
leucine-rich repeat 359..382 CDD:275380 5/22 (23%)
LRR_8 382..441 CDD:290566 21/58 (36%)
leucine-rich repeat 383..406 CDD:275380 6/22 (27%)
leucine-rich repeat 407..430 CDD:275380 8/22 (36%)
LRR_8 431..488 CDD:290566 22/79 (28%)
leucine-rich repeat 431..451 CDD:275380 10/42 (24%)
leucine-rich repeat 454..477 CDD:275380 7/22 (32%)
LRR_8 477..559 CDD:290566 30/82 (37%)
leucine-rich repeat 478..499 CDD:275380 9/20 (45%)
leucine-rich repeat 502..525 CDD:275380 8/22 (36%)
leucine-rich repeat 526..548 CDD:275380 8/22 (36%)
leucine-rich repeat 590..617 CDD:275380 1/26 (4%)
leucine-rich repeat 618..641 CDD:275380 6/22 (27%)
leucine-rich repeat 642..689 CDD:275380 11/51 (22%)
LRRCT 679..736 CDD:214507 7/24 (29%)
leucine-rich repeat 775..796 CDD:275380
LRR_8 797..852 CDD:290566
leucine-rich repeat 797..817 CDD:275380
leucine-rich repeat 818..841 CDD:275380
LRR_8 841..900 CDD:290566
leucine-rich repeat 842..865 CDD:275380
LRR_4 866..907 CDD:289563
leucine-rich repeat 866..889 CDD:275380
leucine-rich repeat 890..911 CDD:275380
TIR 1045..1183 CDD:214587
si:dkey-182i3.11XP_021322095.1 PLN00113 97..>617 CDD:331614 157/595 (26%)
leucine-rich repeat 129..152 CDD:275380 8/22 (36%)
leucine-rich repeat 153..176 CDD:275380 10/41 (24%)
leucine-rich repeat 177..200 CDD:275380 8/22 (36%)
leucine-rich repeat 201..224 CDD:275380 2/22 (9%)
leucine-rich repeat 225..248 CDD:275380 5/22 (23%)
leucine-rich repeat 249..272 CDD:275380 5/22 (23%)
leucine-rich repeat 273..296 CDD:275380 7/22 (32%)
leucine-rich repeat 297..320 CDD:275380 11/24 (46%)
leucine-rich repeat 321..344 CDD:275380 8/22 (36%)
leucine-rich repeat 345..368 CDD:275380 5/22 (23%)
leucine-rich repeat 369..392 CDD:275380 6/22 (27%)
leucine-rich repeat 393..438 CDD:275380 18/44 (41%)
leucine-rich repeat 417..436 CDD:275380 10/18 (56%)
leucine-rich repeat 439..462 CDD:275380 1/22 (5%)
leucine-rich repeat 463..486 CDD:275380 7/22 (32%)
leucine-rich repeat 487..510 CDD:275380 10/22 (45%)
leucine-rich repeat 511..534 CDD:275380 8/22 (36%)
leucine-rich repeat 535..558 CDD:275380 8/22 (36%)
leucine-rich repeat 559..582 CDD:275380 9/67 (13%)
leucine-rich repeat 583..606 CDD:275380 6/22 (27%)
leucine-rich repeat 607..628 CDD:275380 5/22 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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