DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and tlr7

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001120883.1 Gene:tlr7 / 100151703 XenbaseID:XB-GENE-486605 Length:1054 Species:Xenopus tropicalis


Alignment Length:1157 Identity:270/1157 - (23%)
Similarity:442/1157 - (38%) Gaps:312/1157 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   201 NANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLN 265
            ||.|.|.      .:|.|...|.|:|  ||..  ..:..|:|..|:|..::.::.|..::|..|:
 Frog    47 NAKGNVI------VVDCSDRHLTSIP--WGIP--TNVTNLTLTINHIPRISVDSFAEFTNLVELD 101

  Fly   266 ISYN----------HL----VSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLL------ 310
            ...|          |:    :.:...:||....||.|:|.||.|.|.||||...| |||      
 Frog   102 FRCNCVPAKVGPKDHVCTKRLDVEDRSFASLYNLRSLYLDGNQLIEFPKGLPPNL-QLLSLEINN 165

  Fly   311 VLDLSGNQLT----------------------SHHVDNSTFAGLIRLIVLNLSNNALTRIG---S 350
            ::.:|.|.|:                      |..::...|..|..|.:|::.:|.|:.:.   |
 Frog   166 IISISRNNLSELSNIQMLYLGQNCYHRNPCSDSFKIEKDAFKDLKNLSILSMKSNNLSFVPGGLS 230

  Fly   351 KTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAEN--------------------RLHT 395
            .:.||||      :.||:|.:|||.....|.||..|:|:.|                    ::|.
 Frog   231 DSLKELY------LYNNAIQYIEEHDLENLINLEILDLSGNCPRCYNSPFPCTPCPNNAPIQIHP 289

  Fly   396 LDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQL-TEVPEA--VQDLSMLKTL 457
               :.|:.|..|..|.|::|.:..:..|.|:|..:|:.||||.|.| :|:..|  ::.:..||:|
 Frog   290 ---KAFSSLKNLQVLRLHSNSLRSIPEQWFKNNRNLQVLDLSENFLASEISTANFLKYIPSLKSL 351

  Fly   458 DLGEN---QI--SEFK-NNTFRNLNQLTGLRLIDNRIGNITVGMFQ---DLPRLSVLNLAKNRIQ 513
            ||..|   |:  |:.| ::.|.:|..|..||:......|:......   .||.|::|:|:.|.|:
 Frog   352 DLSFNFELQVYPSDLKLSSIFSSLASLETLRIRGYVFQNLKKNNLMPLVHLPNLTLLDLSTNFIK 416

  Fly   514 SIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLV--------WFDY------ 564
            ..:...|.|...::.|.|..|.::..:.  |.:.|.....:|..|.:        :|:|      
 Frog   417 VADFSLFPKFKSLQTIILSNNKISPSSE--ANIDSCSASQVSSGHYIGRTFQEVHYFEYDENARK 479

  Fly   565 --AFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPN--SIELLFINN 625
              |....|..:........:|.|.           :||.|.|.|..:.|....|  .::.|.::.
 Frog   480 CKAKDKENFTFKLFLNESCQAYGQ-----------SLDLSQNNIFFVKATDFTNLSFLKCLNLSG 533

  Fly   626 NIIGQ-IQANTFVDKTRLARVD--------LYANVLSKISLNALRVAPVSAEKPVPEFYLG---G 678
            |.|.| :..:.|.:..||..:|        ||:....:  |..|.|..:|..   ..::|.   .
 Frog   534 NAISQTLNGSEFRNLNRLKYLDFSNNRIDLLYSTAFQE--LTELEVLDISNN---DHYFLAEGIT 593

  Fly   679 NPFECDCSMEWLQRI----NNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYES 739
            :.|....::|.|.::    |.::|..:.|:|             |..||.|              
 Frog   594 HVFNFTKNLEKLTKLMMNNNQISTSTNRHLV-------------SQSLRIL-------------- 631

  Fly   740 HCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLY---LDG 801
                     |::         ||   :.:..|.    |...:.|....|     ::.||   :..
 Frog   632 ---------EFK---------GN---YLNILWK----DGDTRYLNFFKN-----LNKLYKLDISE 666

  Fly   802 NNMPELEVGHLTGR-RNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGL 865
            |::..:..|...|. .:|..|||..:.|.|.....|..|..|.||.|.||.||.:..........
 Frog   667 NSLTFVPPGVFEGMPPDLLELYLARNKLKTFSWDKLHLLEKLSVLDLSNNYLTTVPRELSNCTSS 731

  Fly   866 LRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQYRH----SLQGLTLGRNAWSCRC 926
            :::|.|.||.:..::.......|||:.|.|.:|.:.::.|..:..    :|..|.|..|.:.|.|
 Frog   732 IKKLILSNNKIKKLTPFFLRGSVSLKYLDLSDNLIQNIGHSSFPEDVLDNLTELLLQGNPFKCNC 796

  Fly   927 QQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSD----------LLDASAS 981
                                 ::..|.:.|.:....|.||..|..||.          |||....
 Frog   797 ---------------------NLVWLVSWINQTKVYIPNLVTGVTCSGPGAHRGQSLVLLDLYTC 840

  Fly   982 NISSSQDLAGGYRLPLLAAVLVLIFLVVVLII-----VFVFRESVRMWLFAH------YGVRVCE 1035
            .         .|.|.|:...|...|::.::::     :|.:    ..|...|      :|.:   
 Frog   841 E---------QYHLNLILQALSASFIICLMVVSVSSHLFYW----DFWFIYHLFKAKIHGYK--- 889

  Fly  1036 PRFEDAGKLYDAIILHSEKD---YEFVCRNIAAELE-HGRPPFRLCIQQRD-LPPQASHLQLVEG 1095
             ||...  .|||:|::..||   .::|..::...|| .|.....||:::|| |..|.....|.|.
 Frog   890 -RFPKC--CYDALIMYDTKDSAVSDWVFNDLVNILEKQGNKMLNLCLEERDFLAGQPFLDNLSES 951

  Fly  1096 ARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQK------LVIIEETSVSAEAEDVAELS 1154
            .:.|||.:.||||..:    .:..|:.||:.:.:.|.::      |:::|:|         .:.|
 Frog   952 IQISRKTVFVLTRKYV----KKGHFKTAFYMAHQRLIEEKVDVIILILLEKT---------LQRS 1003

  Fly  1155 PYLK--------SV---PSNRLLTCDRYFWEKLRYAIPIELSPRGNNYTLDH 1195
            .||:        ||   |||.  ....|||..|:.||..|.....:....||
 Frog  1004 RYLRLRKRLCANSVLYWPSNP--NSQSYFWHCLKSAIATENQMAYDKLFKDH 1053

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380 270/1157 (23%)
LRR_RI 210..464 CDD:238064 86/324 (27%)
leucine-rich repeat 212..236 CDD:275380 7/23 (30%)
LRR_8 235..295 CDD:290566 17/73 (23%)
leucine-rich repeat 237..260 CDD:275380 5/22 (23%)
leucine-rich repeat 261..284 CDD:275380 6/36 (17%)
LRR_8 283..345 CDD:290566 25/89 (28%)
leucine-rich repeat 285..308 CDD:275380 13/22 (59%)
leucine-rich repeat 309..334 CDD:275380 8/52 (15%)
LRR_8 334..393 CDD:290566 21/81 (26%)
leucine-rich repeat 335..358 CDD:275380 8/25 (32%)
leucine-rich repeat 359..382 CDD:275380 7/22 (32%)
LRR_8 382..441 CDD:290566 21/78 (27%)
leucine-rich repeat 383..406 CDD:275380 7/42 (17%)
leucine-rich repeat 407..430 CDD:275380 7/22 (32%)
LRR_8 431..488 CDD:290566 23/65 (35%)
leucine-rich repeat 431..451 CDD:275380 9/22 (41%)
leucine-rich repeat 454..477 CDD:275380 11/28 (39%)
LRR_8 477..559 CDD:290566 19/84 (23%)
leucine-rich repeat 478..499 CDD:275380 4/23 (17%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 4/21 (19%)
leucine-rich repeat 590..617 CDD:275380 7/28 (25%)
leucine-rich repeat 618..641 CDD:275380 5/23 (22%)
leucine-rich repeat 642..689 CDD:275380 10/57 (18%)
LRRCT 679..736 CDD:214507 11/60 (18%)
leucine-rich repeat 775..796 CDD:275380 3/20 (15%)
LRR_8 797..852 CDD:290566 19/58 (33%)
leucine-rich repeat 797..817 CDD:275380 5/23 (22%)
leucine-rich repeat 818..841 CDD:275380 8/22 (36%)
LRR_8 841..900 CDD:290566 18/58 (31%)
leucine-rich repeat 842..865 CDD:275380 8/22 (36%)
LRR_4 866..907 CDD:289563 11/40 (28%)
leucine-rich repeat 866..889 CDD:275380 4/22 (18%)
leucine-rich repeat 890..911 CDD:275380 5/24 (21%)
TIR 1045..1183 CDD:214587 46/159 (29%)
tlr7NP_001120883.1 PRK15370 <36..>183 CDD:185268 41/146 (28%)
leucine-rich repeat 54..75 CDD:275380 7/24 (29%)
leucine-rich repeat 76..96 CDD:275380 5/19 (26%)
leucine-rich repeat 97..134 CDD:275380 6/36 (17%)
PLN00113 129..>583 CDD:215061 122/478 (26%)
leucine-rich repeat 135..155 CDD:275380 12/19 (63%)
leucine-rich repeat 156..179 CDD:275380 7/23 (30%)
leucine-rich repeat 180..211 CDD:275380 3/30 (10%)
leucine-rich repeat 212..256 CDD:275380 16/49 (33%)
leucine-rich repeat 213..232 CDD:275380 4/18 (22%)
leucine-rich repeat 257..297 CDD:275380 7/42 (17%)
leucine-rich repeat 298..321 CDD:275380 7/22 (32%)
leucine-rich repeat 348..377 CDD:275380 11/28 (39%)
leucine-rich repeat 405..428 CDD:275380 7/22 (32%)
LRR <490..748 CDD:227223 67/330 (20%)
leucine-rich repeat 503..525 CDD:275380 7/32 (22%)
leucine-rich repeat 526..550 CDD:275380 5/23 (22%)
leucine-rich repeat 551..574 CDD:275380 5/24 (21%)
leucine-rich repeat 575..604 CDD:275380 5/31 (16%)
leucine-rich repeat 605..658 CDD:275380 16/109 (15%)
leucine-rich repeat 628..650 CDD:275380 8/60 (13%)
leucine-rich repeat 659..683 CDD:275380 5/23 (22%)
leucine-rich repeat 684..707 CDD:275380 8/22 (36%)
leucine-rich repeat 708..731 CDD:275380 8/22 (36%)
leucine-rich repeat 732..755 CDD:275380 4/22 (18%)
leucine-rich repeat 756..774 CDD:275380 5/17 (29%)
PCC 760..>843 CDD:188093 20/112 (18%)
TIR_2 895..>998 CDD:390066 30/106 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm14092
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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