Protein Alignment 18w and tlr20.4

DIOPT Version :10

• Sequence 1: NP_476814.1
• Gene: 18w / 37277
• FlyBaseID: FBgn0287775
• Length: 1385
• Species: Drosophila melanogaster
• Sequence 2: XP_073768827.1
• Gene: tlr20.4 / 100005571
• ZFINID: ZDB-GENE-071002-1
• Length: 457
• Species: Danio rerio
• Alignment Length: 491
• Identity: 114/491 - (23%)
• Similarity: 179/491 - (36%)
• Gaps: 162/491 - (32%)

  Fly   790 IPQDVSDLYLDGNNMP-ELEVG-----------HLTGR-----------------RNLRALYLNA 825
            ||.::|::::.....| .|.:|           |:.|:                 ..::|.|:..
Zfish    15 IPSNLSNVFISSGLRPMHLVIGSNTTLNNGLNLHIKGQYVIVEDCNSLLLTSVVTLQIQAAYMIC 79

  Fly   826 SN---------LMTLQNGS-----------LAQLVNLRVLHLENNKLT--ALEGTEFRSLGLLRE 868
            .|         :::|:..|           :.|||:|:.|.|||..||  ...|..|.:|..|.:
Zfish    80 ENEFIGKYVPSVVSLEFQSMFADNIGDLSVINQLVHLKTLKLENIDLTNQPNTGIMFHNLTKLEK 144

  Fly   869 LYLHNNMLTHISNATFEPLVSL--------EVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAWSCR 925
            :.|.|..:..:..:..:.|.:|        |.:.:..|.:....||:|.| .|.|.|     .|.
Zfish   145 MILMNCKIFFLDKSVTKDLKALTSLVLIPKEAVNIIQNFMEQPTHLKYLH-FQCLDL-----YCS 203

  Fly   926 CQQLRELAQFVSDNAMVV-----RDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISS 985
            |.. ..|..::.||..|.     ....|:.||.......|..|.....  :||..||....:.||
Zfish   204 CDN-TWLVSWIRDNGKVEVVMSNPSMEDLRCLTDDEVDHLNFISYAKE--NCSIDLDFVFFSCSS 265

  Fly   986 SQDLAGGYRLPLLAAVLVLIFLVVVLIIVFV--------------FRESVRMWLFAHYGVRVCEP 1036
                           |.:.||:||||:..||              |||::||.....|
Zfish   266 ---------------VFLCIFIVVVLMYKFVGQYFKPFYHIASGWFREALRMKEKQQY------- 308

  Fly  1037 RFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPF-RLCIQQRDLPPQASHLQLVEGAR--- 1097
                   .|||.:.:|.||..:|...:...||...||| |||:..||.  |..| .:||...
Zfish   309 -------RYDAFVSYSGKDEHWVIEELLPNLEQRGPPFLRLCLHSRDF--QLGH-DIVENITDSI 363

  Fly  1098 -ASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYLKSVP 1161
             |||:.:.:::||.|.:.|..:|.:.|.:.                :..|..|:..| .:|:::|
Zfish   364 YASRRTLCLVSRNYLNSNWCSVEMQLATYR----------------LQVEHRDILIL-VFLETIP 411

  Fly  1162 SN---------RLLTCDRY------------FWEKL 1176
            |.         ||:....|            ||::|
Zfish   412 SRLLSSHHRLARLVKTRTYLDWPQEPEMHEAFWDRL 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:404697
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380
		LRR	210..592	CDD:443914
		leucine-rich repeat	212..236	CDD:275380
		leucine-rich repeat	237..260	CDD:275380
		leucine-rich repeat	261..284	CDD:275380
		leucine-rich repeat	285..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..358	CDD:275380
		leucine-rich repeat	359..382	CDD:275380
		leucine-rich repeat	383..406	CDD:275380
		leucine-rich repeat	407..430	CDD:275380
		leucine-rich repeat	431..451	CDD:275380
		leucine-rich repeat	454..477	CDD:275380
		leucine-rich repeat	478..499	CDD:275380
		leucine-rich repeat	502..525	CDD:275380
		leucine-rich repeat	526..548	CDD:275380
		leucine-rich repeat	590..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		LRR	<775..>920	CDD:443914	40/188 (21%)
		leucine-rich repeat	775..796	CDD:275380	2/5 (40%)
		leucine-rich repeat	797..817	CDD:275380	5/48 (10%)
		leucine-rich repeat	818..841	CDD:275380	7/42 (17%)
		leucine-rich repeat	842..865	CDD:275380	10/24 (42%)
		leucine-rich repeat	866..889	CDD:275380	4/22 (18%)
		leucine-rich repeat	890..911	CDD:275380	6/28 (21%)
		TIR	1045..1183	CDD:214587	42/158 (27%)
tlr20.4	XP_073768827.1	None