DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and SLC22A13

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_004247.2	Gene:	SLC22A13 / 9390	HGNCID:	8494	Length:	551	Species:	Homo sapiens

Alignment Length:	516	Identity:	153/516 - (29%)
Similarity:	241/516 - (46%)	Gaps:	54/516 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSC-------KTENVT-------- 73
            ::::||||.|:|:....::.:..|.:.::...|:|:....|..|       .|.|::
Human     7 VLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLSAAEQLVLS 71

  Fly    74 ---------DPC----------------SDECSET-------EFDTSVFQSTIITEWNLTCESKQ 106
                     :||                |...:||       |:..:...| :..|:||.|:.|.
Human    72 VPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPS-LKNEFNLVCDRKH 135

  Fly   107 LASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAV 171
            |...:||:.|.|:|.|:::||...||.||:...|....:..:.||.....|.:..|...||.||.
Human   136 LKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVAT 200

  Fly   172 ATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFV 236
            |.||...::..||.|.|||..|....:|.|..|::|...||..||..|.||..|.:.|...::..
Human   201 AVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLF 265

  Fly   237 IYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPVKKGTVVDL 301
            .|.|.:|||.|||.|.|::|::|::::|.|..|:   ..:.||:   ...|...:....|..:||
Human   266 FYFWALPESARWLLTRGRMDEAIQLIQKAASVNR---RKLSPEL---MNQLVPEKTGPSGNALDL 324

  Fly   302 FRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGR 366
            ||.|.:|..|:.:...|.|..:.|||.:..|...|.:::::..|...|.:|..|....|.:..||
Human   325 FRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGR 389

  Fly   367 KKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVG 431
            |.:.|.:.....|..|::..:......|....|.:|....:..|...|:|..|||||::|.:|:|
Human   390 KWSQLGTLVLGGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMG 454

  Fly   432 LCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPETLEDGE 492
            |..:..|||.|:.||::.|..|...:..||:|...|:|.|....||||.|..|.:||:|.|
Human   455 LVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	130/401 (32%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	124/389 (32%)
SLC22A13	NP_004247.2	2A0119	12..510	CDD:273328	148/504 (29%)
		MFS	139..500	CDD:119392	117/366 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..551		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.910