DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8654 and SLC22A14

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_006713479.2	Gene:	SLC22A14 / 9389	HGNCID:	8495	Length:	675	Species:	Homo sapiens

Alignment Length:	559	Identity:	135/559 - (24%)
Similarity:	226/559 - (40%)	Gaps:	97/559 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TKTGDP---IISQIGDFRRYQ--------------LFFFF---IVLLCK---FGTGWHTLGHIFL 59
            ||..|.   ::..:|:|..:|              .||.|   .|...:   ..|.|       :
Human   127 TKQDDKFANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSW-------I 184

  Fly    60 AAPTPLSCKTE--NVTDP---------C--------------------SDECSETEFDTSVFQST 93
            .|..|...|.|  |:|.|         |                    :|.|.:........:.:
Human   185 LAVGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDTCQDGWIYPDAKKRS 249

  Fly    94 IITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPY 158
            :|.|::|.|..:.....:|.:.|.|:..||::|.:..|:.||.||.|......:|.|........
Human   250 LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNS 314

  Fly   159 YWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRW 223
            :..|..|||.::.:..|...:|..|..|.:..:.|....||....|.:|...|...||.:..|:.
Human   315 FHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIAYSLPHWQL 379

  Fly   224 FQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNK--APTETIRPEIEAAYGA 286
            ......|..|.|:.|||::|||||||...||:.::.::|...|..||  .|:..: .|::
Human   380 LFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLL-DELQ----- 438

  Fly   287 LAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGI 351
             ..|:.|.:.:|:|..:...:...|:.|:..|..|...|:..:..:..||.::...:.:.:.:.:
Human   439 -LPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEV 502

  Fly   352 PGTCLCALMTKYLGRKKT---------------LLLSNGCSALGLILLACLSTQAEAVRVTCATI 401
            |....|..:.:.:|||.:               |.|..|...|.|....|.:|:.:::.:....:
Human   503 PARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLML 567

  Fly   402 GLFGASITFPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIF- 465
            ..|..:.|....:||..||.|||:|::|:||.|:....|:|::..|:.       ..|.:..||
Human   568 REFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILSLTIIS-------QTPSLLPIFL 625

  Fly   466 ----SILAMLGTIFLPETRGTPLPETLEDGETFGRKKKD 500
                :|:|...:..|||||..||.|:|........|.||
Human   626 CCVLAIVAFSLSSLLPETRDQPLSESLNHSSQIRNKVKD 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	108/423 (26%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	101/411 (25%)
SLC22A14	XP_006713479.2	2A0119	141..650	CDD:273328	127/529 (24%)
SLC22A14	XP_006713479.2	MFS	270..641	CDD:119392	96/384 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.980