DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a7

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_445989.2	Gene:	Slc22a7 / 89776	RGDID:	621699	Length:	535	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	149/533 - (27%)
Similarity:	249/533 - (46%)	Gaps:	56/533 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLA-----------APTPL---------- 65
            :.::.::|.|..:||....::.|.:.....|.|..:|:|           ||..|
  Rat     4 EDLLDKVGGFGPFQLRNLVLMALPRMLLPMHFLLPVFMAAVPAHHCALPGAPANLSHQDLWLEAH 68

  Fly    66 ----------SC-------KTENVT-------------DPCSDECSE-TEFDTSVFQSTIITEWN 99
                      ||       ...|||             :|.:..||: .|:|.|.|.|||.|||:
  Rat    69 LPRETDGSFSSCLRFAYPQTVPNVTLGTEVSNSGEPEGEPLTVPCSQGWEYDRSEFSSTIATEWD 133

  Fly   100 LTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCL 164
            |.|:.:.|..::.:...:|:|.|::::|..:||:|||...|......|:.||:...|..|..:.:
  Rat   134 LVCQQRGLNKITSTCFFIGVLVGAVVYGYLSDRFGRRRLLLVAYVSSLVLGLMSAASINYIMFVV 198

  Fly   165 FRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSIT 229
            .|.|...|.||.......|.:|.:..:.|.:..::..:.::.|...|||..|.||.|||...:.|
  Rat   199 TRTLTGSALAGFTIIVLPLELEWLDVEHRTVAGVISTVFWSGGVLLLALVGYLIRSWRWLLLAAT 263

  Fly   230 IFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPVK 294
            :..:..:|.||.||||.|||.|.|:::::.|.|...||.|..|........||....:...:.::
  Rat   264 LPCVPGIISIWWVPESARWLLTQGRVEEAKKYLLSCAKLNGRPVGEGSLSQEALNNVVTMERALQ 328

  Fly   295 KGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCAL 359
            :.:.:|||||..:|..::.....|..|...|||....||.||.|::.:..:...|.:|...:...
  Rat   329 RPSYLDLFRTSQLRHISLCCMMVWFGVNFSYYGLTLDVSGLGLNVYQTQLLFGAVELPSKIMVYF 393

  Fly   360 MTKYLGRKKTL--LLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFP 422
            :.:.|||:.|.  :|.......|..||..|.|::....:  ..:|...:...|...||:..||:|
  Rat   394 LVRRLGRRLTEAGMLLGAALTFGTSLLVSLETKSWITAL--VVVGKAFSEAAFTTAYLFTSELYP 456

  Fly   423 TVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPET 487
            ||:|.:|:||.:::||:|:.:|||...|....|.:..:.:|..:::|....:.||||:...||||
  Rat   457 TVLRQTGLGLTALMGRLGASLAPLAALLDGVWLLLPKVAYGGIALVAACTALLLPETKKAQLPET 521

  Fly   488 LEDGETFGRKKKD 500
            ::|.|....:::|
  Rat   522 IQDVERKSTQEED 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	123/403 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	116/391 (30%)
Slc22a7	NP_445989.2	2A0119	11..521	CDD:273328	144/511 (28%)
Slc22a7	NP_445989.2	MFS	144..511	CDD:119392	105/368 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910