DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and PHO84

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_013583.1	Gene:	PHO84 / 854916	SGDID:	S000004592	Length:	587	Species:	Saccharomyces cerevisiae

Alignment Length:	501	Identity:	115/501 - (22%)
Similarity:	182/501 - (36%)	Gaps:	135/501 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 SKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCV--------SPYYW 160
            |:.|..:|.|:   |.:.|...||..||..||:..:    .|:||. :|||.        ||...
Yeast   103 SQTLLKVSTSV---GTVIGQFGFGTLADIVGRKRIY----GMELII-MIVCTILQTTVAHSPAIN 159

  Fly   161 FYCL---FRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNI-------GHASLALFA 215
            |..:   :|.::.:...|....|.::..|....|.|.  ||:..:..|.       |..:|.|.|
Yeast   160 FVAVLTFYRIVMGIGIGGDYPLSSIITSEFATTKWRG--AIMGAVFANQAWGQISGGIIALILVA 222

  Fly   216 YFIRE---------------------WRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSI 259
            .:..|                     ||......|:..:..:.:...:|||||:     :||.:.
Yeast   223 AYKGELEYANSGAECDARCQKACDQMWRILIGLGTVLGLACLYFRLTIPESPRY-----QLDVNA 282

  Fly   260 KILEKIAKCNKAPTE----TIRPEIEAAYGALAARQPVK-------KGTVVDLFR----TPYMRI 309
            | ||..|...:...|    ....|..|..|...|...|:       |.:..|..|    ..|.:|
Yeast   283 K-LELAAAAQEQDGEKKIHDTSDEDMAINGLERASTAVESLDNHPPKASFKDFCRHFGQWKYGKI 346

  Fly   310 KTIFMANNWLVVCMVYYG----TAQYVSALG----------------GNIFISNAIAAGVGIPGT 354
             .:..|.:|..:.:.:||    :|..:..:|                ||:.:   |.|| .:||.
Yeast   347 -LLGTAGSWFTLDVAFYGLSLNSAVILQTIGYAGSKNVYKKLYDTAVGNLIL---ICAG-SLPGY 406

  Fly   355 CLCALMTKYLGRKKTLLLSNGCSALGLILLACL------------STQAEAVRVTCATIGLFGAS 407
            .:.......:|||...|       .|.|:|..|            .....|:.|.|.....||.:
Yeast   407 WVSVFTVDIIGRKPIQL-------AGFIILTALFCVIGFAYHKLGDHGLLALYVICQFFQNFGPN 464

  Fly   408 ITFPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIV----------DLAAYGLWVAPL-- 460
            .|   .::..||.|||..||:..|:.:..|::|:|:|...:          |......|:..:
Yeast   465 TT---TFIVPGECFPTRYRSTAHGISAASGKVGAIIAQTALGTLIDHNCARDGKPTNCWLPHVME 526

  Fly   461 IFGIFSILAMLGTIFLPETRGTPLPETLE------DGETFGRKKKD 500
            ||.:|.:|.:..|:.:|||:...|.|..|      |..|...:.|:
Yeast   527 IFALFMLLGIFTTLLIPETKRKTLEEINELYHDEIDPATLNFRNKN 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	110/480 (23%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	106/470 (23%)
PHO84	NP_013583.1	2A0109	49..554	CDD:129965	111/481 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
TreeFam	0	0.000	Not matched by this tool.
	3	2.940