DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	155/525 - (29%)
Similarity:	235/525 - (44%)	Gaps:	74/525 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TGDPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCK---------------- 68
            |...|:.::|....:|.....::.|...|...|.|..||.|......|:
  Rat     2 TFSEILDRVGSMGPFQYLHVTLLALPVLGIANHNLLQIFTATTPVHHCRPPPNASIGPWVLPLDP 66

  Fly    69 ---------------------TENVTDPCSDECSETEFDTSVFQS---TIITEWNLTCESKQLAS 109
                                 |:..|:||        .|..::.|   ||:.||:|.|.|.:|..
  Rat    67 NGKPEKCLRFVHLPNASLPNDTQRATEPC--------LDGWIYNSTRDTIVIEWDLVCSSNKLKE 123

  Fly   110 LSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATA 174
            ::|||.|.|||.|..:.|..:||:||:|.......|...:|.....||....|.:||||...:.:
  Rat   124 MAQSIFMAGILVGGPVIGELSDRFGRKPILTWSYLMLAASGSGAAFSPSLPVYMIFRFLCGCSIS 188

  Fly   175 GTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYI 239
            |...::.:|.:|.|....|.:.:......:.||...|:..||.|.:|||.|.:.:....:|.:..
  Rat   189 GISLSTVILNVEWVPTSMRAISSTSIGYCYTIGQFILSGLAYAIPQWRWLQLTSSAPFFIFSLLS 253

  Fly   240 WLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTE-----------TIRPEIEAAYGALAARQPV 293
            |.||||.|||..:||..|::|.|:::|..|....|           .::.:|.:|        .|
  Rat   254 WWVPESIRWLVLSGKYSKALKTLQRVATFNGKKEEGKKLTIEELKFNLQKDITSA--------KV 310

  Fly   294 KKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCA 358
            |.| :.||||...:|..|..::..|......||..|..|...|.||:|...|..||.||...:..
  Rat   311 KYG-LSDLFRVSILRRVTFCLSLAWFSTGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITI 374

  Fly   359 LMTKYLGRKKT---LLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGEL 420
            |...||||:.|   |||..|.:.|.||.   :.::.:.:|...|..|....|.:|..::||..||
  Rat   375 LSLSYLGRRITQSFLLLLAGGAILALIF---VPSEMQLLRTALAVFGKGCLSGSFSCLFLYTSEL 436

  Fly   421 FPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLP 485
            :|||:|.:|:|:.::..|:||::|||:........::..:|||..::|......||.||...|||
  Rat   437 YPTVLRQTGMGISNVWARVGSMIAPLVKITGELQPFIPNVIFGTTALLGGSAAFFLLETLNRPLP 501

  Fly   486 ETLED 490
            ||:||
  Rat   502 ETIED 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	135/418 (32%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	128/406 (32%)
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	149/511 (29%)
		MFS	124..492	CDD:119392	118/379 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020