Protein Alignment CG8654 and SLC22A5

DIOPT Version :10

• Sequence 1: NP_611451.1
• Gene: CG8654 / 37275
• FlyBaseID: FBgn0034479
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001295051.1
• Gene: SLC22A5 / 6584
• HGNCID: 10969
• Length: 581
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 154/552 - (27%)
• Similarity: 251/552 - (45%)
• Gaps: 94/552 - (17%)

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTP-----------LSCKTENVTDP 75
            |.:.:.:|::..:|...||::.......|:..|..:||.| ||           ||....|.|.|
Human     5 DEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIA-TPEHRCRVPDAANLSSAWRNHTVP 68

  Fly    76 ------------C----------------------------SDECSE-TEFDTSVFQSTIITE-- 97
                        |                            .:.|.: .||...|:.|||:||
Human    69 LRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEQD 133

  Fly    98 ----------------------WNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFL 140
                                  |||.||....|.|:.|:..:|:|.||.:.|..:||:||:....
Human   134 SGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLF 198

  Fly   141 TCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREM-----VAILY 200
            ....||.....:...|..:..:.:...||.:........:|||..||:|...|.:     |.|.|
Human   199 VTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFY 263

  Fly   201 QIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKI 265
            .    .|:..|.|||||||:||....::|:..::.|...|.:|||||||.:.|:.:::..|:.|.
Human   264 A----FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKA 324

  Fly   266 AKCN--KAPTETIRP-EIEAAYGALAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYG 327
            ||.|  ..|:....| |::    .|::::. :...::||.||..:|:.||.....|:.:.:.|:|
Human   325 AKANGIVVPSTIFDPSELQ----DLSSKKQ-QSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG 384

  Fly   328 TAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAE 392
            .:.....|.|:||::..::|.|.:|...|..|:.:||.|:.::..:.......|:.:..:.....
Human   385 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLY 449

  Fly   393 AVRVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWV 457
            .:......:|.||.:..|..||:|..||:|||||:.|||:.|...|:|||::|..|.|.||..::
Human   450 YLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFL 514

  Fly   458 APLIFGIFSILAMLGTIFLPETRGTPLPETLE 489
            ..::.|..:||..:.|:||||:.|||||:|::
Human   515 PYILMGSLTILTAILTLFLPESFGTPLPDTID 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_611451.1	MFS_SLC22	82..477	CDD:340875	126/427 (30%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	152/541 (28%)