Protein Alignment CG8654 and SLC22A4

DIOPT Version :9

• Sequence 1: NP_001246441.1
• Gene: CG8654 / 37275
• FlyBaseID: FBgn0034479
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 146/548 - (26%)
• Similarity: 246/548 - (44%)
• Gaps: 85/548 - (15%)

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKT----------------- 69
            |.:|:.:|::..:|...||::.......|::.:..:|||......|:.
Human     5 DEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPL 69

  Fly    70 -----ENVTDPCS----------------------------DECSE-TEFDTSVFQSTIITEWNL 100
                 ..|...||                            :.|.: .||...|:.||::|||||
Human    70 RLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWNL 134

  Fly   101 TCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGL----IVCVSPYYW- 160
            .||......|:.|:..:|:|.||.:.|..:||:||:........:|  ||.    |..:|   |
Human   135 VCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQ--TGFSFLQIFSIS---WE 194

  Fly   161 -FYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIP-FNIGHASLALFAYFIREWRW 223
             |..|| .:|.:........:|:|..||:|...|.:.:.|.... |.:|:..|.|||||||:||.
Human   195 MFTVLF-VIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRM 258

  Fly   224 FQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALA 288
            ...::|:..::.|...|.:|||||||.:..:..::..|::|.||.|......:      .:.::.
Human   259 LLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAV------IFDSVE 317

  Fly   289 ARQPVK--KGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGI 351
            ...|:|  |..::|||||..:.|.||.....|::..:.|:..:.....|.|:.:::..::|.:.|
Human   318 ELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEI 382

  Fly   352 PGTCLCALMTKYLGRK----KTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPN 412
            |......|:.:.|.|:    ..|....|.    |:.:..:......:.:....:|.||.:..|..
Human   383 PAYITAWLLLRTLPRRYIIAAVLFWGGGV----LLFIQLVPVDYYFLSIGLVMLGKFGITSAFSM 443

  Fly   413 VYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLP 477
            :|::..||:||:||:..||:.|...|:|||:||..|.|.||...:..::.|..::|..:.|:|.|
Human   444 LYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFP 508

  Fly   478 ETRGTPLPETLEDGETF-----GRKKKD 500
            |:.|..||||||..:..     |:|.:|
Human   509 ESLGMTLPETLEQMQKVKWFRSGKKTRD 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	123/414 (30%)
		MFS	87..477	CDD:119392	117/402 (29%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	137/521 (26%)
		MFS	123..508	CDD:119392	117/400 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.940