Protein Alignment CG8654 and SLC22A2

DIOPT Version :10

• Sequence 1: NP_611451.1
• Gene: CG8654 / 37275
• FlyBaseID: FBgn0034479
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 148/545 - (27%)
• Similarity: 253/545 - (46%)
• Gaps: 72/545 - (13%)

  Fly    20 TGDPIISQIGDFRRYQLFFFFIVLL----------------------CK--------FGTGWHTL 54
            |.|.::...|:|..:|...||::.|                      |:        ...||...
Human     4 TVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSPA 68

  Fly    55 GHIFLAAP--------TPLSCKTENV-----TDPCSDECSETEFDTS-----------VFQ---S 92
            ..:....|        :|..|:...|     |..|.|..:..:.:.|           |::   |
Human    69 EELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETPGS 133

  Fly    93 TIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSP 157
            :|:||:||.|.:..:..|.||.|.:|...||:..|..|||:||:...||...:....|:::.:||
Human   134 SIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISP 198

  Fly   158 YYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWR 222
            .|.:..:||.:..:.:.......::|:.|.||.:.|..|.|.||:.:.:|...||..||.:..||
Human   199 TYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWR 263

  Fly   223 WFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCN--KAPTETIRPEIEAAYG 285
            |.||::::.:..|::|.|.:|||||||.:..|..::::|::.|||.|  ..|....|..:|...|
Human   264 WLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLRLEEETG 328

  Fly   286 ALAARQPVKK--GTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAG 348
                    ||  .:.:||.|||.:|..|:.:..||....::|.|...::...|.||::....:|.
Human   329 --------KKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSAL 385

  Fly   349 VGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNV 413
            |..|...:..|....:||:.....||..:....:....:....:.:::..:.:|..|.::.:..|
Human   386 VEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIV 450

  Fly   414 YLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWV-APL-IFGIFSILAMLGTIFL 476
            .|...||:||.:|:.||.:||.:..||.|:.|.:| .....:|: .|| :||:..::|....:.|
Human   451 CLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLV-YRLTNIWLELPLMVFGVLGLVAGGLVLLL 514

  Fly   477 PETRGTPLPETLEDGETFGRKKKDQ 501
            |||:|..||||:|:.|...|.:|::
Human   515 PETKGKALPETIEEAENMQRPRKNK 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_611451.1	MFS_SLC22	82..477	CDD:340875	117/414 (28%)
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	140/520 (27%)
		Proline-rich sequence. /evidence=ECO:0000269|PubMed:26979622	284..288		3/3 (100%)