Protein Alignment CG8654 and SLC22A3

DIOPT Version :9

• Sequence 1: NP_001246441.1
• Gene: CG8654 / 37275
• FlyBaseID: FBgn0034479
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 180/552 - (32%)
• Similarity: 267/552 - (48%)
• Gaps: 82/552 - (14%)

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTL--GHIFLAA-PTPLSCKTE------------- 70
            |..:.::|:|.|:|...|  :|||..|..:..|  |.:||.. |....|:..
Human     5 DEALQRVGEFGRFQRRVF--LLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSP 67

  Fly    71 ----NVTDPCS-----------------DECSETEFDTSVF------------------------ 90
                |.|.|.|                 :..:::...||..
Human    68 EEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGGWR 132

  Fly    91 ----QSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGL 151
                .|||::|::|.|.:..:..|:|:|:.||.|.|:...|..||||||...:|..|....:||:
Human   133 YAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGV 197

  Fly   152 IVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAY 216
            :|..:|.:..:.:||||..|...||..|.:|::.||||.|:|.:|.|:.|:.|.:|...|...||
Human   198 VVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAY 262

  Fly   217 FIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIE 281
            ||..|:..|.:||:.|.:|::|.|:||||||||.|..|.||:::||.:|||||.....:...||
Human   263 FIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEI- 326

  Fly   282 AAYGALAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIA 346
                 ....:.|...:.:||.|||.||..|:.:...|....:||.|....:..:|||::|...|:
Human   327 -----TVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFIS 386

  Fly   347 AGVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFP 411
            ..|.:||..|..|..:.|||:.....||..:.:..::.|.|......:|.|.||:|..|.::.|.
Human   387 GVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFE 451

  Fly   412 NVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAP-LIVDLAAYGLWVAPLIFGIFSILAMLGTIF 475
            .|||...||:||.:|:.||.|||.:...|.|:|| |:..|||..|.:..:||||.:.:.....:.
Human   452 IVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVML 516

  Fly   476 LPETRGTPLPETLEDGETF--------GRKKK 499
            ||||:|..||||::|.|..        ||.||
Human   517 LPETKGIALPETVDDVEKLGSPHSCKCGRNKK 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	152/430 (35%)
		MFS	87..477	CDD:119392	145/418 (35%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	171/523 (33%)
		MFS	149..518	CDD:119392	137/374 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920