DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and SLC22A1

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_005267159.1	Gene:	SLC22A1 / 6580	HGNCID:	10963	Length:	610	Species:	Homo sapiens

Alignment Length:	504	Identity:	140/504 - (27%)
Similarity:	229/504 - (45%)	Gaps:	71/504 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TGDPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTENVTD---------- 74
            |.|.|:.|:|:...:|...|.|:.|.........:|.:||.......|::..|.:
Human     3 TVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWSPA 67

  Fly    75 -----------PCSD----ECSETEFDTS-----------------------------VFQ---S 92
                       |..:    :|...|.|.:                             |:.   |
Human    68 EELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTPGS 132

  Fly    93 TIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSP 157
            :|:||:||.|.......|.||.:..|.||||:..|.||||:||:...|....:..::|:::..||
Human   133 SIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSP 197

  Fly   158 YYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWR 222
            .|....|||.|..:.:.|.....:.|:.|.||...|..|||:||:.|.:|..:|...||.:..||
Human   198 NYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWR 262

  Fly   223 WFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCN-KAPTETIRPEIEAAYGA 286
            |.|.::::.:.:|::|.|.||||||||.:..:..::|||::.||:.| |.|...::        .
Human   263 WLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLK--------M 319

  Fly   287 LAARQPVKK---GTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAG 348
            |:..:.|.:   .:..||||||.:|.:|..:...|....::|.|...::.|..||:::....:|.
Human   320 LSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSAL 384

  Fly   349 VGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNV 413
            |.|||..:..:....:||...:.:||..:....:::..:|.....:.:....:|..|.:|....:
Human   385 VEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMI 449

  Fly   414 YLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVA-PLI 461
            .|...||:||.||:.||.:||.:..||.|:.|.|| .....:|.| |||
Human   450 CLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIV-FRLREVWQALPLI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	123/414 (30%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	122/412 (30%)
SLC22A1	XP_005267159.1	2A0119	12..499	CDD:273328	136/495 (27%)
SLC22A1	XP_005267159.1	MFS	118..484	CDD:119392	115/373 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020