Protein Alignment CG8654 and sv2ca

DIOPT Version :9

• Sequence 1: NP_001246441.1
• Gene: CG8654 / 37275
• FlyBaseID: FBgn0034479
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001121811.1
• Gene: sv2ca / 562345
• ZFINID: ZDB-GENE-060526-233
• Length: 745
• Species: Danio rerio
• Alignment Length: 662
• Identity: 124/662 - (18%)
• Similarity: 201/662 - (30%)
• Gaps: 261/662 - (39%)

  Fly    24 IISQIGDFR-RYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTENVTDPCSDECSETEFDT 87
            ||.:.|..| ::||||...:.|...|.....:|.:..:|.          ||.|..:.|
Zfish   143 IIQECGHGRFQWQLFFTLGLALMSDGVEVFVVGFVLPSAE----------TDMCVPDSS------ 191

  Fly    88 SVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLI 152
                    :.|            ..|||.||::.|:..:|..||:.|||...|.|   ..:.|..
Zfish   192 --------SGW------------LGSIVYLGMMVGAFFWGGMADKVGRRQCLLIC---MSLNGFF 233

  Fly   153 VCVSPY---YWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKRE----------MVAILYQ--- 201
            ..:|.:   |..:.|.|.:......|.:...|....|::..:||.          |:..:|.
Zfish   234 AFLSSFVQGYGLFLLCRMIAGFGIGGAVPIVFSYFAEVLAREKRGEHLSWLCMFWMIGEIYASAM 298

  Fly   202 ----IP------------FNIGHASLALF----AYFIREWRWFQFSITIFSIVFVIYIWLVPESP 246
                ||            .|..|.:...|    ||....||.|.....:..:..|:.:..:||||
Zfish   299 AWAIIPHYGQITTASSQFINYHHYTSWSFSMGSAYQFHSWRVFVVVCALPCVCAVVALTFMPESP 363

  Fly   247 RWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAAR-QPVKKGTV--------VD-- 300
            |:....||.|::..||::|...|                 :.|| ||.|..||        :|
Zfish   364 RFYLEVGKHDEAWMILKQIHDTN-----------------MRARGQPEKVFTVNRIKIPKQIDEF 411

  Fly   301 --------LFRTPYMRIK---------------------TIFMANNWLVVCMVYYG--------- 327
                    .|.....|||                     |:.:|..||.:...|||
Zfish   412 VEMHESGNFFSKAIFRIKTELHGIWLNFLKCFNYPVKESTVKLAIVWLTLSFGYYGLSVWFPDVI 476

  Fly   328 ----------------------------------------------------------------- 327
                                                                             
Zfish   477 KHLQNDEYASKGQRHNNERIEDFTFNFTLENQIHTNSLFINDRFINMKFKSVTFINSTFQSCFFE 541

  Fly   328 ----------TAQYVSALGGN-------------------------------------IFISNAI 345
                      ...::.|:..|                                     ::..|.:
Zfish   542 DVTSVGSFFRNCTFIEAVFYNTDIDDSKLKNTDVINSTFYHNKTGCQMTFEDDYSAYWVYFVNFL 606

  Fly   346 AAGVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASIT- 409
            .....:||..:.||:...:||...|..|...|.:....|...::::..:.:.|...||   ||:
Zfish   607 GTLAVLPGNIVSALLMDKIGRLSMLGFSMILSGISCFFLWFGTSESMMIGMLCLYNGL---SISA 668

  Fly   410 FPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTI 474
            :.::.:...||:||..|.:|.|.|:.:.::.:::..||.. :..|:..|..|....|:|...|.:
Zfish   669 WNSLDVVTTELYPTDRRGTGFGFCNALCKLAAVMGNLIFG-SLVGITKAIPILLASSVLVGGGLV 732

  Fly   475 --FLPETRGTPL 484
              .||:||...|
Zfish   733 GLRLPDTRSNVL 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	108/600 (18%)
		MFS	87..477	CDD:119392	103/589 (17%)
sv2ca	NP_001121811.1	synapt_SV2	3..745	CDD:130366	124/662 (19%)
		Spt5_N	73..>141	CDD:288770
		MFS	157..>360	CDD:119392	48/241 (20%)
		MFS	588..>711	CDD:119392	26/126 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940