DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Orct2

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	178/543 - (32%)
Similarity:	277/543 - (51%)	Gaps:	79/543 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTE--------------NV 72
            |..|..:|||.|||...:|::.|......:|.|..:||.|.....|...              |:
  Fly     4 DEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHLWNL 68

  Fly    73 TDPCSDECS--------------------ETE------FDTSVFQSTIITEWNLTCESKQLASLS 111
            :.|.::.||                    ||:      :|.|.:.::.:|||||.|....:|:.|
  Fly    69 SYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCGRDFMAATS 133

  Fly   112 QSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGT 176
            .|:.|||:|.|||:||..:|:|||:|.......:|::.|::..|:|.|:.|...|.:|...|:|.
  Fly   134 DSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVGATTSGV 198

  Fly   177 MTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWL 241
            ...::|:.||:|||.||....|...:.|::|....|:||||:.:|||.|.::|:..::|:.|.|:
  Fly   199 FLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGLIFMFYYWI 263

  Fly   242 VPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALA------------ARQPVK 294
            :|||.|||...|:.|.:|..::|.|:.||         :|.:..||:            |:|.::
  Fly   264 IPESARWLLLKGRKDCAIANMQKAARFNK---------VEISDEALSELLDEGENSEEKAKQKLE 319

  Fly   295 -----KG---TVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGI 351
                 :|   :|.|||..|.:|.||:.:..:|||...||||.:...|.||||:.::..|:..|.|
  Fly   320 DQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGAVEI 384

  Fly   352 PGTCLCALMTKYLGRKKTLLLSNGCSAL-GLILLA--CLSTQAEAVRVTCATIGLFGASITFPNV 413
            |......|.....||:..|.   ||..: ||.|||  .:..:...:.|.||.:|....:.::..|
  Fly   385 PAYIFLLLTLNRWGRRSILC---GCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLAITASYGTV 446

  Fly   414 YLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLW--VAPLIFGIFSILAMLGTIFL 476
            |::..|.||||||:..:|..|||.||..::||.:..||.  :|  :..||.|..:::|.|.::.|
  Fly   447 YIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLAT--IWKPLPLLICGSLTLVAGLLSLLL 509

  Fly   477 PETRGTPLPETLEDGETFGRKKK 499
            |||...|:.||:.|||.||:|.|
  Fly   510 PETHNKPMLETIADGERFGKKTK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	147/426 (35%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	141/414 (34%)
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	167/522 (32%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	132/389 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I682
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13331at6656
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8406
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
	10	10.000