DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8654 and CG6231

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	133/525 - (25%)
Similarity:	234/525 - (44%)	Gaps:	54/525 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQ-----LF-FFFIVLLCKFGT--------------------GWHTLGHIFLA 60
            |.|:::.|||.|||     || |..|::...:.|                    .:..:|.|:..
  Fly     4 DQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEIYAQ 68

  Fly    61 APTPLSC------KTENVTDPCSDECSETEFDTSVFQSTIITEWNLTCESKQLASLSQSIVMLGI 119
            ...| ||      ...||| ..|..|.:..::......::.||.|..|:|...|.:.||:..:|.
  Fly    69 FENP-SCTRLDDINGHNVT-VSSKACEKWIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGS 131

  Fly   120 LFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLL 184
            :.|::.:|:.:|:.||.||.:...|...........:.....:.|.||:..:|........::::
  Fly   132 VVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIV 196

  Fly   185 MEIVGPKKREM-----VAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLVPE 244
            :|.:.|..|.:     |.:.|    .:|.......|..:..|:.:....::..::.|:|.::|.|
  Fly   197 LEYIRPSMRTLGLNMAVGLFY----CLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQE 257

  Fly   245 SPRWLFTTGKLDKSIKILEKIAKCN-----KAPTETIRPEIEAAYGALAARQPVKKGTVVDLFRT 304
            |.:||.|...:|.:|..|:::||.|     :|..:..|...:..:..|.. ...|:.|::|:|||
  Fly   258 SAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQMTHEMLGG-DDKKQATLLDMFRT 321

  Fly   305 PYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRK-- 367
            |.||..|:.:....:|:.:.|...::.|..:|.:.||..:::|...:|.:.|..|:...:|||
  Fly   322 PRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGM 386

  Fly   368 --KTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGL-FGASITFPNVYLYGGELFPTVVRSSG 429
              .:||:....:|...|.:|.......|:.:.|.||.. ||.:|::.:...|..||.||.||..|
  Fly   387 ASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISYESGSQYATELIPTCVRGQG 451

  Fly   430 VGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPETLEDGETF 494
            |....:.|...|.:||.|:.|..:......:|.|:.........:.||||....||.|:|:||.|
  Fly   452 VAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGEVF 516

  Fly   495 GRKKK 499
            |:.::
  Fly   517 GKGER 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	104/416 (25%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	98/404 (24%)
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	125/504 (25%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	91/378 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	5	5.060