DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8654 and CG7342

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	125/509 - (24%)
Similarity:	229/509 - (44%)	Gaps:	39/509 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLA----------------APTPLSC--K 68
            |.|:.:.|||.|.|:....:..:....:..|......::                :|...||  .
  Fly     5 DKILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCADGLPASIESPVDSSCLPL 69

  Fly    69 TENVTDPCSDECSETEFDTSVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRY 133
            ..|::.|  :.|....::..:...:..:|.:..|......:|.||:..:|.:.||::.|..||..
  Fly    70 NRNISTP--NTCYSYNYELYMGYQSFPSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVV 132

  Fly   134 GRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREM-VA 197
            ||.|..:....:.:...|:...|.....:|:||.:..:||.......::|:||.:.|..|.: ::
  Fly   133 GRLPILIVANLIAMTGNLLTIWSTNVTLFCMFRMISGIATDSNFVMMYILVMEYMRPSVRTLGLS 197

  Fly   198 ILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKIL 262
            |.....:.:|..:....|..:|.||.|..:.::..:|...:..:||||.:||.:..|.|.::..|
  Fly   198 ICIGFFYCLGSMAAPWIAVLMRSWRGFLLTTSLPLLVVPFFYLIVPESIQWLISKQKYDSAVVCL 262

  Fly   263 EKIAKCNKAPTETIRPEIEAAYGAL-----AARQPVKKGT-VVDLFRTPYMRIKTIFMANNWLVV 321
            :::||.|....|      |:||...     .::|..|... ::|||:||.:|..|:.:....:|:
  Fly   263 KRVAKINGRHVE------ESAYAEFIEECKCSQQNQKASPHLLDLFQTPRLRRHTLILFFKSMVI 321

  Fly   322 CMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRK----KTLLLSNGCSAL--G 380
            .:.|...::.|..||.:.|:..:::|...:|...|...:...:|||    .:||||....::  |
  Fly   322 TLCYDAVSRNVQGLGISPFVMFSLSATAILPACLLIIALQDRIGRKAMASASLLLSGIFISVTGG 386

  Fly   381 LILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAP 445
            :|..|..|.:...:.|:.:.:|.||.::.:.:...|..||.||.||..||....:.|...:..:.
  Fly   387 IIFAASASDKTTTLLVSLSVVGRFGVTVAYNSGAQYATELIPTCVRGQGVAAVHVAGYAFTFFSA 451

  Fly   446 LIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPETLEDGETFGRKKK 499
            .|:...:....:..:|.|:.|:|.....:.||||....||.:|||||.||:..:
  Fly   452 YILFTRSVFSPLPEIILGVLSLLGACLCLLLPETLHRTLPTSLEDGENFGKNDR 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	104/414 (25%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	98/402 (24%)
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	114/486 (23%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	34/149 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	5	5.060